Modified-release topical hydrogels: a ten-year review

Croisfelt, Fernanda Machado; Tundisi, Louise Lacalendola; Ataide, Janaína Artem; Silveira, Edgar; Tambourgi, Elias Basile; Jozala, Ângela Faustino; Souto, Eliana B.; Mazzola, Priscila Gava

doi:10.1007/s10853-019-03557-x

Cited by 43 publications

(20 citation statements)

References 210 publications

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“…However, nanotechnologists are mostly interested in hydrophilic polymers of natural sources because of their accomplished characteristics of affordability, biocompatibility, little or no toxicity, easy availability, and non-irritant profile. In addition to mucoadhesion, hydrophilic polymers swell and form a gel-like layer on the nanoparticle surface, which reduces fluid entry into the polymer core, resulting in sustained drug release [ 125 ]. Numerous natural polymers, such as guar gum, alginate, and chitosan, were explored as ocular nano delivery agents [ 126 , 127 , 128 ].…”

Section: Encapsulation Of Ergot Alkaloids For Ocular Administratiomentioning

confidence: 99%

Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems

et al. 2020

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Several pharmacological properties are attributed to ergot alkaloids as a result of their antibacterial, antiproliferative, and antioxidant effects. Although known for their biomedical applications (e.g., for the treatment of glaucoma), most ergot alkaloids exhibit high toxicological risk and may even be lethal to humans and animals. Their pharmacological profile results from the structural similarity between lysergic acid-derived compounds and noradrenalin, dopamine, and serotonin neurotransmitters. To reduce their toxicological risk, while increasing their bioavailability, improved delivery systems were proposed. This review discusses the safety aspects of using ergot alkaloids in ocular pharmacology and proposes the development of lipid and polymeric nanoparticles for the topical administration of these drugs to enhance their therapeutic efficacy for the treatment of glaucoma.

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Section: Encapsulation Of Ergot Alkaloids For Ocular Administratiomentioning

confidence: 99%

Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems

et al. 2020

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“…In the last decades, the aim of numerous studies has been the development of gels/hydrogels from natural based materials. 1,2 Among the variety of biodegradable polymers from renewable resources, chitosan and alginates represent a great alternative to obtain the desired materials with biodegradable and non-toxic characteristics. Both polymers have polysaccha-ride structure, with a difference in their anionic and cationic character due to their functional groups.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Rençber¹,

Cheaburu-Yılmaz²,

Köse³

et al. 2019

Cellulose Chem. Technol.

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Interpolymeric complexes (IPCs) have the advantage of combined properties of their constituent polymers. They are easy to prepare under mild conditions and do not require high processing costs. The interpolymeric complexes of alginate, chitosan and Nystatin, as antifungal drug systems, represent an alternative for mucosal illness treatment. The composition of the two polymers is a key parameter in obtaining the desired properties for pharmaceutical formulations. IPCs of sodium alginate (SA) and chitosan (CS) were prepared via solution mixing method with various compositions, followed by coacervation in 2-propanol. The outcome obtained from rheological measurements was that the complex SA/CS 60/40 (v/v %) fulfilled the requirements of a semi-solid formulation, e.g. pseudoplasticity. Nystatin showed very good compatibility with the polymeric system. The drug loaded gels showed better rheological, textural and mechanical properties (e.g. pseudoelasticity, spreadability, surface adhesion etc.). The final gel formulations showed no cytotoxic effects in the cell culture assay.

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“…The high content of water (about 70–99%) in hydrogels provides good biocompatibility, biodegradability, low cytotoxicity, moreover, they pose physicochemical similarities to the native extracellular matrix (ECM) [ 78 , 79 , 80 , 81 ]. Besides, hydrogels demonstrate low elastic surface tension with water and biological fluids, which makes them tolerable [ 81 , 82 ]. In the literature, several classifications of hydrogels have been reported, which is due to their different properties.…”

Section: Hydrogelsmentioning

confidence: 99%

“…The properties of hydrogels can be designed and tailored for the special requirements in the different applications. Figure 4 shows a classification of hydrogels along with all categories and subcategories [ 82 , 83 ].…”

Section: Hydrogelsmentioning

confidence: 99%

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

et al. 2020

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Periodontitis (PD) is a chronic inflammatory disease of periodontal tissues caused by pathogenic microorganisms and characterized by disruption of the tooth-supporting structures. Conventional drug administration pathways in periodontal disease treatment have many drawbacks such as poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells. To overcome this limitation, controlled drug delivery systems have been developed as a potential method to address oral infectious disease ailments. The use of drug delivery devices proves to be an excellent auxiliary method in improving the quality and effectiveness in periodontitis treatment, which includes inaccessible periodontal pockets. This review explores the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. Furthermore, to present a more comprehensive understanding of the difficulties concerning the treatment of PD, a brief description of the mechanism and development of the disease is outlined.

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Modified-release topical hydrogels: a ten-year review

Cited by 43 publications

References 210 publications

Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems

Natural Ergot Alkaloids in Ocular Pharmacotherapy: Known Molecules for Novel Nanoparticle-Based Delivery Systems

Preparation and Characterization of Alginate and Chitosan Ipc Based Gel Formulation for Mucosal Application

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

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