Modifying Distant Effect of High Dilutions of Inorganic and Biological Substances

Alinkina, E. S.; Molodtsova, I. V.; Petrova, A. O.; Stepanov, G. O.; Don, E. S.

doi:10.1007/s10517-023-05862-7

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…The conditionally holographic structure of PDs can probably explain the ability of PDs to exhibit a limited distant effect (i.e., without direct contact with their target at a distance of up to several centimeters), recently discovered using released-active antibodies to IFN-γ as an example [62,[114][115][116][117].…”

Section: Characteristics Of Tumor Growth In the Lewis Lung Carcinoma ...mentioning

confidence: 99%

“…An important detail is that, using released-active antibodies to IFN-γ and PD of sodium sulfate, we have previously discovered that released-active dilutions produced from high-molecular-weight substances had a more pronounced ability to exhibit the distant effect [14,62,[114][115][116]. The main regulators of functions in the organism are proteins capable of intermolecular interactions [118].…”

Section: Characteristics Of Tumor Growth In the Lewis Lung Carcinoma ...mentioning

confidence: 99%

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The Supramolecular Matrix Concept

Epstein

2023

Symmetry

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It has been established that dilutions of a variety of substances, when exposed to vibration in the process of their preparation, acquire not only new structural characteristics in the form of nano-associates but also new physical properties, regardless of the presence of the initial substance. One of the most important properties of these dilutions is the ability to modify the physico–chemical and biological activity of the initial substance as well as exert non-contact, “distant”, effects. Here, we propose a novel hypothesis that the basis of modifying activity is the transformation of target molecules to a more harmonious (symmetrical) state supported by a supramolecular matrix, a structural unit of a structured space.

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Section: Characteristics Of Tumor Growth In the Lewis Lung Carcinoma ...mentioning

confidence: 99%

Section: Characteristics Of Tumor Growth In the Lewis Lung Carcinoma ...mentioning

confidence: 99%

The Supramolecular Matrix Concept

Epstein

2023

Symmetry

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Biological Medicines Prepared Using Vibration Processing Are Able to Influence Their Targets Without Direct Contact With Them

Don,

Zakharova,

Yaroshenko

et al. 2024

Dose-Response

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Recently, there has been a radical change in understanding of the nature of drugs based on highly diluted solutions. It has been established that their activity does not depend on the content of the original substance in dilutions, but is a consequence of the technological processing (TP) of dilutions with vibration, which accompanies each dilution during the preparation of solutions and, among others, leads to the formation of nanoparticles with certain properties. Repeated vibration treatment leads to the appearance of modifying activity that is absent in the original substance, and these effects of TP solutions can be exerted without direct contact with their targets, which clearly indicates the physical nature of the TP solution’s activity. In the framework of this article, a statistically significant effect of TP antibodies to the insulin receptor on glucose consumption by CHO cells both with and without contact exposure, as compared with control ( P < 0.05) was shown in the vast majority of the experiments. The obtained results shed light on a possible source of activity of drugs based on TP antibodies, which should be associated with the applied vibration effect and can manifest itself both with contact exposure and without it.

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Phenomenon of Post-Vibration Interactions

Petrova,

Tarasov,

Gorbunov

et al. 2024

Symmetry

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During the preparation of high dilutions, repeated external vibration (shaking) is used. We hypothesized that it was the vibration treatment, and not the negligible content of the initial substance, that underlies the activity of highly diluted preparations. In order to test this, the vibration was separated from the dilution process. After vibrating two tubes together on a vortex mixer (one containing water and the other the initial substance) the electrical conductivity and radio frequency radiation intensity of water differed from the unvibrated control, and the ability to exert a modifying effect on the target solution appeared, as assessed using ELISA and terahertz spectroscopy, appeared. Thus, the properties of the neutral carrier (water) changed after non-contact exposure to the initial substance. We have named this process ‘crossing’ and its products ‘aqueous iterations of the initial substance’. Several aqueous iterations with different physical properties were obtained, some of which have a modifying effect and others cause various chemical (catalytic) and biological (antiviral) effects similar to those of the initial substance. This indicates that during crossing, substances enter into post-vibration supramolecular interactions. At the nanoscale level, aqueous iterations and the initial substance are structurally symmetrical, which allows us to assume that the preservation of the symmetry of substances subjected to vibration treatment is the basis of the post-vibration interaction phenomenon.

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Modifying Distant Effect of High Dilutions of Inorganic and Biological Substances

Cited by 3 publications

References 13 publications

The Supramolecular Matrix Concept

The Supramolecular Matrix Concept

Biological Medicines Prepared Using Vibration Processing Are Able to Influence Their Targets Without Direct Contact With Them

Phenomenon of Post-Vibration Interactions

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