Modifying Effect of Various Inorganic Salts on the Diuretic Action of Salyrgan

Electrolyte Equilibrium During Mercurial Diuresis 12

“…It has long been known that acidifying salts potentiate, and alkalinizing salts depress mercurial diuresis (2,36,37). The potentiation with acidifying salts has been found to be synergistic rather than additive.…”

“…All were chosen on the basis of their willingness and ability to cooperate in the collection of specimens and the consumption of a constant diet. Six were males 1 This investigation was supported by research grants from the National Heart Institute of the National Institutes of Health, U. S. Public Health Service, the Grant Foundation, Mead Johnson and Company, and Lakeside Laboratories, Inc. 2 Presented in abstract form at the 42nd Annual Meeting of the American Society for Clinical Investigation, Atlantic City, N. J., May 1, 1950. 8 Present address: New England Center Hospital and Tufts College Medical School, Boston, Mass. and four were females.…”

“…This differential loss of chloride was shown to result in hypochloremic alkalosis. It was further observed that the administration of acidifying salts prevented the occurrence of alkalosis and at the same time enhanced diuresis (1,2).…”

Potentiation of Diuretic Action of Mercuhydrin by Ammonium Chloride 12

“…That the effect is synergistic and not merely additive was conclusively demonstrated by Ethridge, Myers and Fulton (8). The mechanism of this synergism is not well understood, and reports as to its nature are conflicting.…”

“…The mechanism of this synergism is not well understood, and reports as to its nature are conflicting. Acidosis as the responsible factor has been emphasized by several investigators (1,4,8). This view also received support when it was noted that the administration of alkalinizing salts actually diminished the efficacy of mercurial diuretics (8).…”