Modifying the Blood's Physical and Chemical Parameters Using Cold Helium Plasma: In Vitro Study

Мартусевич, А. К.; Galka, A. G.; Golygina, Elena S.

doi:10.1615/plasmamed.2020036212

Cited by 5 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21 Taking this into account, we assume that under the used mode of application of the helium flow, oxidative stress is realized in the blood samples, which leads to the detected shifts in their crystallogenic properties. 26 A similar negative effect was observed for nonionized argon. Under the influence of this factor, there was an activation of plasma crystallogenesis associated with an increase in the density of structural elements without their complication.…”

Section: Discussionsupporting

confidence: 55%

“…The study of the biological effects of cold plasma using various carrier gases was carried out on a stand previously described by the experiment. 26 The effect was carried out by direct contact of the plasma torch with the surface of the biological fluid contained in a plastic tube (the distance between them is 2 to 3 mm). Helium and argon grade A (99.9% purity) were used as carrier gases.…”

Section: A Materials and Experiments Descriptionmentioning

confidence: 99%

“…In a previously published study, we showed that helium cold plasma significantly transforms the crystallogenesis of blood serum in vitro, which is additionally accompanied by a change in its dielectric properties. 26 In addition, we have previously demonstrated the dependence of metabolic shifts in the biological fluid on the time of exposure to cold plasma. 21 At the same time, the effect of the carrier gas on the modulating effect of cold plasma on the crystallization of blood serum has not been studied.…”

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Comparative Study of the Influence of Helium and Argon Plasma on Crystallogenic Properties of the Blood

et al. 2021

Self Cite

View full text Add to dashboard Cite

The aim of this study was to compare the biological effects of helium and argon plasma in vitro. The cold plasma was generated using a device developed at the Institute of Applied Physics of the Russian Academy of Sciences (Nizhny Novgorod), which uses the principle of microwave ionization of the gas flow. We studied the crystallogenic activity of blood plasma. The description of dehydrated blood plasma samples was performed morphologically, using a system of visuametric parameters. Main morphometric parameters for analysis of blood plasma crystallization include crystallizability, structure index, facia destruction degree, and size of marginal zone. This study allowed us to establish that the effect of helium and argon in both free and ionized forms on the crystallogenic activity of blood varies significantly. The effect of cold plasma in general should be described as more favorable relative to the corresponding nonionized fluxes. At the same time, the most optimal nature of the reaction of the biological fluid was recorded when using a helium cold plasma. A specific feature of the helium flow is the suppression of the crystallogenic activity of the biological fluid, and the argon flow leads to its increase. Ionization of gases optimizes the nature of their influence, moreover, according to the modeling effect, the helium cold plasma is closest to the control sample.

show abstract

Section: Discussionsupporting

confidence: 55%

Section: A Materials and Experiments Descriptionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Comparative Study of the Influence of Helium and Argon Plasma on Crystallogenic Properties of the Blood

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Human whole blood samples served as the main test biosystem, convenient and indicative in terms of evaluating the effects of cold plasma in experiments in vitro. It was found that cold helium plasma modifies various components of blood plasma metabolism [ 52 , 53 ] and erythrocytes [ 54 ]. In particular, in blood plasma, the studied factor induced moderate stimulation of free radical processes with a short exposure (1–2 min) against the background of more pronounced activation of the antioxidant system [ 52 ].…”

Section: The Authors’ Own Research In the Field Of Studying Local And...mentioning

confidence: 99%

Cold Argon Athmospheric Plasma for Biomedicine: Biological Effects, Applications and Possibilities

et al. 2022

Self Cite

View full text Add to dashboard Cite

Currently, plasma medicine is a synthetic direction that unites the efforts of specialists of various profiles. For the successful formation of plasma medicine, it is necessary to solve a large complex of problems, including creating equipment for generating cold plasma, revealing the biological effects of this effect, as well as identifying and justifying the most promising areas of its application. It is known that these biological effects include antibacterial and antiviral activity, the ability to stimulate hemocoagulation, pro-regenerative properties, etc. The possibility of using the factor in tissue engineering and implantology is also shown. Based on this, the purpose of this review was to form a unified understanding of the biological effects and biomedical applications of argon cold plasma. The review shows that cold plasma, like any other physical and chemical factors, has dose dependence, and the variable parameter in this case is the exposure of its application. One of the significant characteristics determining the specificity of the cold plasma effect is the carrier gas selection. This gas carrier is not just an ionized medium but modulates the response of biosystems to it. Finally, the perception of cold plasma by cellular structures can be carried out by activating a special molecular biosensor, the functioning of which significantly depends on the parameters of the medium (in the field of plasma generation and the cell itself). Further research in this area can open up new prospects for the effective use of cold plasma.

show abstract

Experimental Evaluation of the Effect of Argon Cold Plasma on Oxidative Metabolism of the Blood

et al. 2022

View full text Add to dashboard Cite

Modifying the Blood's Physical and Chemical Parameters Using Cold Helium Plasma: In Vitro Study

Cited by 5 publications

References 0 publications

Comparative Study of the Influence of Helium and Argon Plasma on Crystallogenic Properties of the Blood

Comparative Study of the Influence of Helium and Argon Plasma on Crystallogenic Properties of the Blood

Cold Argon Athmospheric Plasma for Biomedicine: Biological Effects, Applications and Possibilities

Experimental Evaluation of the Effect of Argon Cold Plasma on Oxidative Metabolism of the Blood

Contact Info

Product

Resources

About