Modulated 3D Cross-Correlation Dynamic Light Scattering Applications for Optical Biosensing and Time-Dependent Monitoring of Nanoparticle-Biofluid Interactions

Schintke, Silvia; Frau, Eleonora

doi:10.3390/app10248969

Cited by 9 publications

(8 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In future work, more advanced algorithms designed for DLS analysis should be explored for potential improvements in resolution and performance. 40–43 In addition, for accurate uncertainty estimates in fitted parameters, correlations between g ( k , τ ) points could be included and a Bayesian fitting algorithm may be advantageous as an alternative to least-squares fits.…”

Section: Discussionmentioning

confidence: 99%

Sizing multimodal suspensions with differential dynamic microscopy

Bradley,

Martinez,

Arlt

et al. 2023

Soft Matter

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Sizing multimodal suspensions with differential dynamic microscopy

Bradley,

Martinez,

Arlt

et al. 2023

Soft Matter

View full text Add to dashboard Cite

show abstract

“…Serum albumins make up the most abundant fraction of water-soluble proteins in the blood plasma [26]. Bovine Serum Albumin (BSA) has become a common model protein for biosensing applications [27][28][29] as it is readily available commercially, stable and its optical properties are well known [30,31]. Here, simple BSA-multilayers are employed in proof-of-principle experiments to outline the sensing performance of the n-Ge antenna platform.…”

Section: Biosensing Resultsmentioning

confidence: 99%

Terahertz subwavelength sensing with bio-functionalized germanium fano-resonators

et al. 2022

View full text Add to dashboard Cite

Localized Surface Plasmon Resonances (LSPR) based on highly doped semiconductors microstructures, such as antennas, can be engineered to exhibit resonant features at THz frequencies. In this work, we demonstrate plasmonic antennas with increased quality factor LSPRs from Fano coupling to dark modes. We also discuss the advances in the biofunctionalization of n-doped Ge antennas for specific protein immobilization and cell interfacing. Finally, albumin biolayers with a thickness of a few hundred nanometers are used to demonstrate the performance of the fano-coupled n-Ge antennas as sensors. A resonant change of over 10% in transmission, due to the presence of the biolayer, can be detected within a bandwidth of only 20 GHz.

show abstract

“…Detailed descriptions of the device can be found in the literature [25][26][27]. DLS is widely used in biosensing to study nanoparticles, proteins, and their interactions [28]; measure nanoparticle size [29]; and detect specific inhibition of nanoparticle aggregation [30].…”

Section: Discussionmentioning

confidence: 99%

FPGA Correlator for Applications in Embedded Smart Devices

Moore¹,

Lin²

2022

Biosensors

View full text Add to dashboard Cite

Correlation has a variety of applications that require signal processing. However, it is computationally intensive, and software correlators require high-performance processors for real-time data analysis. This is a challenge for embedded devices because of the limitation of computing resources. Hardware correlators that use Field Programmable Gate Array (FPGA) technology can significantly boost computational power and bridge the gap between the need for high-performance computing and the limited processing power available in embedded devices. This paper presents a detailed FPGA-based correlator design at the register level along with the open-source Very High-Speed Integrated Circuit Hardware Description Language (VHDL) code. It includes base modules for linear and multi-tau correlators of varying sizes. Every module implements a simple and unified data interface for easy integration with standard and publicly available FPGA modules. Eighty-lag linear and multi-tau correlators were built for validation of the design. Three input data sets—constant signal, pulse signal, and sine signal—were used to test the accuracy of the correlators. The results from the FPGA correlators were compared against the outputs of equivalent software correlators and validated with the corresponding theoretical values. The FPGA correlators returned results identical to those from the software references for all tested data sets and were proven to be equivalent to their software counterparts. Their computation speed is at least 85,000 times faster than the software correlators running on a Xilinx MicroBlaze processor. The FPGA correlator can be easily implemented, especially on System on a Chip (SoC) integrated circuits that have processor cores and FPGA fabric. It is the ideal component for device-on-chip solutions in biosensing.

show abstract

Modulated 3D Cross-Correlation Dynamic Light Scattering Applications for Optical Biosensing and Time-Dependent Monitoring of Nanoparticle-Biofluid Interactions

Cited by 9 publications

References 22 publications

Sizing multimodal suspensions with differential dynamic microscopy

Sizing multimodal suspensions with differential dynamic microscopy

Terahertz subwavelength sensing with bio-functionalized germanium fano-resonators

FPGA Correlator for Applications in Embedded Smart Devices

Contact Info

Product

Resources

About