Modulating effect of inositol hexaphosphate on arachidonic acid-dependent pathways in colon cancer cells

Kapral, Małgorzata; Wawszczyk, Joanna; Sośnicki, Stanisław; Jesse, Katarzyna; Węglarz, Ludmiła

doi:10.1016/j.prostaglandins.2017.08.002

Cited by 8 publications

(6 citation statements)

References 48 publications

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“…In contrast, IP6 reduced proliferation and induced apoptosis and differentiation of many types of malignant cells. Moreover, proinflammatory cytokine levels were reportedly reduced by IP6 62 .…”

Section: Discussionmentioning

confidence: 99%

Chemoprotective effects of inositol hexaphosphate against cyclophosphamide-induced testicular damage in rats

Alkhalaf

Alansari

Alshubaily

et al. 2020

Sci Rep

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Cyclophosphamide (CP) is commonly used as an anticancer agent but has been associated with high toxicity in several animal organs, including the testes. Inositol hexaphosphate (IP6) is a polyphosphorylated carbohydrate that is present in foods with high fibre contents and has a wide range of essential physiological and pathological activities. Thus, we estimated the defensive effects of IP6 against CP-related testicular toxicity in rats. Sperm counts, motilities, viabilities and abnormalities and levels of testosterone, luteinising hormone and follicle-stimulating hormone were evaluated. Testicle specimens were also processed for histological and biochemical analyses, including determinations of malondialdehyde, nitric oxide, total antioxidant capacity, alkaline phosphatase, acid phosphatase, gamma glutamyl transferase, ß-glucuronidase, c-reactive protein, monocyte chemoattractant protein and leukotriene-4 and in comet assays. CP treatments were associated with deleterious histopathological, biochemical and genetic changes in rat testicles, and these were ameliorated by IP6 supplements in drinking water.

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Section: Discussionmentioning

confidence: 99%

Chemoprotective effects of inositol hexaphosphate against cyclophosphamide-induced testicular damage in rats

Alkhalaf

Alansari

Alshubaily

et al. 2020

Sci Rep

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“…MAR can significantly regulate the invasion and metastasis of colon cancer cell lines [42]. Other signaling pathways also affect or regulate invasion and metastasis of colon cancer to a certain extent [43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology and Molecular Docking Validation to Reveal the Pharmacological Mechanisms of Kangai Injection against Colorectal Cancer

Zheng

Wang

Yue

et al. 2022

BioMed Research International

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Background. Kangai injection is a traditional Chinese medicine (TCM) mixed by extracts from astragalus, ginseng, and kurorinone with modern technology. It is a commonly used antitumor injection in China, but the mechanism of Kangai injection in the treatment of colorectal cancer (CRC) is still unclear. The purpose of this study is to explore the mechanism of Kangai injection against CRC using network pharmacology and molecular docking technology. Methods. Targets of Kangai injection in CRC were predicted by SwissTargetPrediction and DisGeNET databases. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) were performed by using the DAVID database. A component-disease-target gene-pathway network was constructed by Cytoscape 3.8.0 software. Results. 114 overlapping targets of Kangai injection and CRC were used to construct a PPI network, and the top 10 hub targets of Kangai injection were rated from high to low as TP53, VEGFA, EGFR, TNF, ESR1, STAT3, HSP90AA1, HDAC1, AR, and MMP9. The ingredient-target-disease interactive network was constructed, which included 22 compounds and 114 overlapping targets with 161 nodes and 707 edges. Entries of enrichment analysis were obtained based on P value (<0.05), which included 19 of GO-MF, 217 of GO-BP, 8 of GO-CC, and 13 KEGG. Molecular docking analysis showed that Kangai injection strongly interacted with top 10 hub target proteins. Conclusion. Network pharmacology intuitively showed the multicomponent, multiple targets, and multiple pathways of Kangai injection in the treatment of CRC. The molecular docking experiment verified that compounds of Kangai injection had good binding ability with top 10 hub target proteins as well.

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“…Also, the knock-out of 15-PGDH has been associated with increased resistance to aspirin and celecoxib [69]. Finally, the treatment of colorectal cancer tumor cells with IP6 (inositol hexaphosphate) decreases COX-2 mRNA expression and activates genes of the lipoxygenase pathway, which reduced the concentration of PGE 2 [70].…”

Section: Prostaglandins In Digestive System and Pancreas Cancermentioning

confidence: 99%

The Role of Prostaglandins in Different Types of Cancer

Jara-Gutiérrez

Baladrón

2021

Cells

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The prostaglandins constitute a family of lipids of 20 carbon atoms that derive from polyunsaturated fatty acids such as arachidonic acid. Traditionally, prostaglandins have been linked to inflammation, female reproductive cycle, vasodilation, or bronchodilator/bronchoconstriction. Recent studies have highlighted the involvement of these lipids in cancer. In this review, existing information on the prostaglandins associated with different types of cancer and the advances related to the potential use of them in neoplasm therapies have been analyzed. We can conclude that the effect of prostaglandins depends on multiple factors, such as the target tissue, their plasma concentration, and the prostaglandin subtype, among others. Prostaglandin D2 (PGD2) seems to hinder tumor progression, while prostaglandin E2 (PGE2) and prostaglandin F2 alpha (PGF2α) seem to provide greater tumor progression and aggressiveness. However, more studies are needed to determine the role of prostaglandin I2 (PGI2) and prostaglandin J2 (PGJ2) in cancer due to the conflicting data obtained. On the other hand, the use of different NSAIDs (non-steroidal anti-inflammatory drugs), especially those selective of COX-2 (cyclooxygenase 2), could have a crucial role in the fight against different neoplasms, either as prophylaxis or as an adjuvant treatment. In addition, multiple targets, related to the action of prostaglandins on the intracellular signaling pathways that are involved in cancer, have been discovered. Thus, in depth research about the prostaglandins involved in different cancer and the different targets modulated by them, as well as their role in the tumor microenvironment and the immune response, is necessary to obtain better therapeutic tools to fight cancer.

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Modulating effect of inositol hexaphosphate on arachidonic acid-dependent pathways in colon cancer cells

Cited by 8 publications

References 48 publications

Chemoprotective effects of inositol hexaphosphate against cyclophosphamide-induced testicular damage in rats

Chemoprotective effects of inositol hexaphosphate against cyclophosphamide-induced testicular damage in rats

Network Pharmacology and Molecular Docking Validation to Reveal the Pharmacological Mechanisms of Kangai Injection against Colorectal Cancer

The Role of Prostaglandins in Different Types of Cancer

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