Modulating effects of bodyweight unloading on the lower limb nociceptive withdrawal reflex during symmetrical stance

Serrao, Mariano; Spaich, Erika G.; Andersen, Ole Kæseler

doi:10.1016/j.clinph.2011.09.006

Cited by 7 publications

(11 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stimulation delivered at the proximal part of the sole of the foot evoked the smallest NWR response in the BF, RF, TA, and VL muscles. This is in accordance with previous studies for the BF, TA, and VL muscles (Spaich et al, 2004;Serrao et al, 2012b). Similarly, the smallest flexion of the knee joint was evoked by stimulation at the proximal part of the sole of the foot.…”

Section: Stimulation Site Modulationsupporting

confidence: 85%

“…The largest reflex was obtained during HO when the stimulation was delivered in the arch of the foot. This response is related to the degree of unloading of the starting leg in line with prior studies in symmetrical stance (Serrao et al, 2012b). Additionally, NWR responses were smallest during HC in order to prevent loss of balance and destabilization in agreement with observations during walking (Spaich et al, 2004).…”

Section: Posture Modulationsupporting

confidence: 84%

“…This modulation was primarily observed in the TA muscle during symmetrical stance and during steady gait (Spaich et al, 2004;Emborg et al, 2009), and also in BF, and VL muscles (Serrao et al, 2012b). However, it has not previously been investigated how the NWR is site modulated during gait initiation.…”

Section: Stimulation Site Modulationmentioning

confidence: 97%

“…In symmetrical standing, larger reflexes are obtained at higher degrees of unloading (Serrao et al, 2012b). In the GIP, as soon as the starting leg is unloaded and prior to any movement, the excitability of the NWR in hip and knee flexor muscles is also increased (Serrao et al, 2012a).…”

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Stimulation site and phase modulation of the withdrawal reflex during gait initiation

Richard

Spaich

Serrao

et al. 2015

Clinical Neurophysiology

Self Cite

View full text Add to dashboard Cite

Section: Stimulation Site Modulationsupporting

confidence: 85%

Section: Posture Modulationsupporting

confidence: 84%

Section: Stimulation Site Modulationmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Stimulation site and phase modulation of the withdrawal reflex during gait initiation

Richard

Spaich

Serrao

et al. 2015

Clinical Neurophysiology

Self Cite

View full text Add to dashboard Cite

“…In humans, acute unloading the bodyweight results in a general increase of the withdrawal reflex excitability to prepare the limb in taking the first walking step (Serrao et al. ). This mechanism is, however, unlikely to add to pressure hyperalgesia in HLS rats, since it starts to develop only after about a week of HLS (Chowdhury et al.…”

Section: Discussionmentioning

confidence: 99%

Animal model of simulated microgravity: a comparative study of hindlimb unloading via tail versus pelvic suspension

et al. 2013

View full text Add to dashboard Cite

The aim of this study was to compare physiological effects of hindlimb suspension (HLS) in tail- and pelvic-HLS rat models to determine if severe stretch in the tail-HLS rats lumbosacral skeleton may contribute to the changes traditionally attributed to simulated microgravity and musculoskeletal disuse in the tail-HLS model. Adult male Sprague-Dawley rats divided into suspended and control-nonsuspended groups were subjected to two separate methods of suspension and maintained with regular food and water for 2 weeks. Body weights, food and water consumption, soleus muscle weight, tibial bone mineral density, random plasma insulin, and hindlimb pain on pressure threshold (PPT) were measured. X-ray analysis demonstrated severe lordosis in tail- but not pelvic-HLS animals. However, growth retardation, food consumption, and soleus muscle weight and tibial bone density (decreased relative to control) did not differ between two HLS models. Furthermore, HLS rats developed similar levels of insulinopenia and mechanical hyperalgesia (decreased PPT) in both tail- and pelvic-HLS groups. In the rat-to-rat comparisons, the growth retardation and the decreased PPT observed in HLS-rats was most associated with insulinopenia. In conclusion, these data suggest that HLS results in mild prediabetic state with some signs of pressure hyperalgesia, but lumbosacral skeleton stretch plays little role, if any, in these pathological changes.

show abstract

Modulating effects of bodyweight unloading on the lower limb nociceptive withdrawal reflex during symmetrical stance

Cited by 7 publications

References 22 publications

Stimulation site and phase modulation of the withdrawal reflex during gait initiation

Stimulation site and phase modulation of the withdrawal reflex during gait initiation

Animal model of simulated microgravity: a comparative study of hindlimb unloading via tail versus pelvic suspension

Adaptive Behavior of the Spinal Cord in the Transition from Quiet Stance to Walking: The Use of Widthrawal Reflexes to Support Gait Initiation

Contact Info

Product

Resources

About