Modulating mTOR Signaling as a Promising Therapeutic Strategy for Atherosclerosis

Abstract

For more than a decade, atherosclerosis has been one of the leading causes of death in developed countries. The issue of treatment and prevention of the disease is especially acute. Despite the huge amount of basic and clinical research, a significant number of gaps remain in our understanding of the pathogenesis of atherosclerosis, and only their closure will bring us closer to understanding the causes of the disease at the cellular and molecular levels and, accordingly, to the development of an effective treatment. One of the seemingly well-studied elements of atherogenesis is the mTOR signaling pathway. However, more and more new details are still being clarified. Therapeutic strategies associated with rapamycin have worked well in a number of different diseases, and there is every reason to believe that targeting components of the mTOR pathway may pay off in atherosclerosis as well.

Emerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration

“…18 Several studies have confirmed that the mTOR signalling pathway plays an important role in various degenerative diseases, including osteoarthritis, diabetes, atherosclerosis, and Parkinson's disease. [19][20][21][22] Liu et al 23 used the LDH model to induce radicular pain in rats. Intraperitoneal injection of AMP-activated protein kinase (AMPK) activators can activate the AMPK signalling pathway in dorsal root ganglion neurones, inhibit mTOR signalling, and alleviate LDH-induced radicular pain, suggesting that inhibition of mTOR signalling can alleviate radicular pain caused by IVD protrusion-mediated compression.…”

Lipopolysaccharides and Cellular Senescence: Involvement in Atherosclerosis

“…Furthermore, LPS inhibits the expression of Sirt3, which ameliorates lipid deposition and endothelial dysfunction and attenuates atherosclerosis [ 68 , 69 , 70 ]. In contrast, LPS induces the activation of mTOR, which induces monocyte adhesion and smooth muscle cell proliferation and enhances atherosclerosis [ 71 , 72 , 73 ].…”

Recent advances of the mammalian target of rapamycin signaling in mesenchymal stem cells

“…Atherosclerosis is a common age-related disease, and increasing age is one of the major risk factors for developing atherosclerosis ( Wang and Bennett, 2012 ). One of the phenotypic manifestations of the arteries is atherosclerosis, which is a chronic inflammatory disease ( Poznyak et al, 2022 ). Primary atherosclerosis may be a phenotypic feature of mitochondrial disease.…”