Modulating oxidative stress and neurogenic inflammation: the role of topiramate in migraine treatment
Qiao-Wen Chen,
Run-Tian Meng,
Chih-Yuan Ko
Abstract:Migraine is a chronic, recurrent neurovascular disorder characterized by episodes closely associated with neurovascular hypersensitivity. Oxidative stress can worsen the hypersensitive state of the central nervous system, which in turn can trigger pro-inflammatory factors that result in neurogenic inflammation. Topiramate is frequently used as a preventative measure for migraines, but there is currently little empirical data to support its efficacy through pathways related to neurogenic inflammation and oxidat… Show more
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