Modulating PCGF4/BMI1 Stability Is an Efficient Metastasis-Regulatory Strategy Used by Distinct Subtypes of Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma

Hu, Jinjing; Xu, Hao; Ma, Xiaojun; Bai, Mingzhen; Zhou, Yongqiang; Miao, Ruidong; Wang, Fanghong; Li, Xun; Cheng, Bo

doi:10.1016/j.ajpath.2024.03.012

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Immune Cells In Tumor Microenvironment (Tme) Of Btc1

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2024

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“…pCAFs activate the IL-6/phosphorylated STAT3 pathway to increase the stability of PCGF4, while rCAFs trigger the proteasome-dependent degradation of PCGF4. 183 …”

Section: Immune Cells In Tumor Microenvironment (Tme) Of Btcmentioning

confidence: 99%

Focusing on the Immune Cells: Recent Advances in Immunotherapy for Biliary Tract Cancer

Ni,

Xu,

et al. 2024

CMAR

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Biliary tract cancer (BTC) represents a challenging malignancy characterized by aggressive behavior, high relapse rates, and poor prognosis. In recent years, immunotherapy has revolutionized the treatment landscape for various cancers, but its efficacy in BTC remains limited. This article provides a comprehensive overview of the advances in preclinical and clinical studies of immunotherapy for BTC. We explore the potential of immune checkpoint inhibitors in reshaping the management of BTC. Despite disappointing results thus far, ongoing clinical trials are investigating the combination of immunotherapy with other treatment modalities. Furthermore, research on the tumor microenvironment has unveiled novel targets for immunotherapeutic interventions. By understanding the current state of immunotherapy in BTC and highlighting future directions, this article aims to fuel further exploration and ultimately improve patient outcomes in this challenging disease.

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“…pCAFs activate the IL-6/phosphorylated STAT3 pathway to increase the stability of PCGF4, while rCAFs trigger the proteasome-dependent degradation of PCGF4. 183 …”

Section: Immune Cells In Tumor Microenvironment (Tme) Of Btcmentioning

confidence: 99%

Focusing on the Immune Cells: Recent Advances in Immunotherapy for Biliary Tract Cancer

Ni,

Xu,

et al. 2024

CMAR

View full text Add to dashboard Cite

show abstract

Modulating PCGF4/BMI1 Stability Is an Efficient Metastasis-Regulatory Strategy Used by Distinct Subtypes of Cancer-Associated Fibroblasts in Intrahepatic Cholangiocarcinoma

Cited by 1 publication

References 51 publications

Focusing on the Immune Cells: Recent Advances in Immunotherapy for Biliary Tract Cancer

Focusing on the Immune Cells: Recent Advances in Immunotherapy for Biliary Tract Cancer

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