Modulating the controlled release of hydroxychloroquine mobilized on pectin films through film-forming pH and incorporation of nanocellulose

Nanocellulose has lately emerged as one of the most promising “green” materials due to its unique properties. Nanocellulose can be mainly divided into three types, i.e., cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial cellulose (BC). With the rapid development of technology, nanocellulose has been designed into multidimensional structures, including 1D (nanofibers, microparticles), 2D (films), and 3D (hydrogels, aerogels) materials. Due to its adaptable surface chemistry, high surface area, biocompatibility, and biodegradability, nanocellulose-based composite materials can be further transformed as drug delivery carriers. Herein, nanocellulose-based composite material used for drug delivery was reviewed. The typical drug release behaviors and the drug release mechanisms of nanocellulose-based composite materials were further summarized, and the potential application of nanocellulose-based composite materials was prospected as well.

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“…Fick's diffusion [144] Chitosan/CNCs films Doxorubicin Under acidic pH conditions, the drug release amount is higher.…”

Section: Hydrophilic-drug Release Behaviorsmentioning

confidence: 99%

Nanocellulose-Based Composite Materials Used in Drug Delivery Systems

et al. 2022

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“…Nanocellulose, chiefly in the form of cellulose nanocrystals, has been successfully used to develop mechanically strong and water resistant pectin-based composite films and composites, 13 suitable for the controlled release of important drugs such as hydroxychloroquine, 32 or even as biodegradable and biocompatible light lenses due to excellent optical properties. 33 Compared to expensive CNC, 34 however, CytroCell micronized cellulose is obtained in one pot, at negligible cost, directly along with the same highly bioactive pectin (IntegroPectin) 18…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

CytroCell Micronized Cellulose Enhances the Structural and Thermal Properties of IntegroPectin Cross-Linked Films

Scurria

Pagliaro

Pantaleo

et al. 2022

ACS Appl. Bio Mater.

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Added to grapefruit IntegroPectin in solution, the micronized cellulose CytroCell, coproduct of the IntegroPectin extraction via hydrodynamic cavitation, enhances the structural and thermal properties of the resulting cross-linked composite films. The films become strong but remain highly flexible as no transition glass temperature is observed, whereas the thermal properties are substantially improved. No organic solvent, acid, or base is used from the extraction of the pectin and cellulose biopolymers through filming their nanocomposites, thereby establishing a completely green route to a class of bio-based 2D films (and 3D scaffolds) with numerous potential applications in regenerative medicine, in tissue engineering, and in the treatment of infections.

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Food Waste-Derived Sources: Synthesis, Properties and Applications in Biomedical Engineering

Zain

Chai

2023

Sustainable Material for Biomedical Engineering Application

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Modulating the controlled release of hydroxychloroquine mobilized on pectin films through film-forming pH and incorporation of nanocellulose

Cited by 8 publications

References 67 publications

Nanocellulose-Based Composite Materials Used in Drug Delivery Systems

Nanocellulose-Based Composite Materials Used in Drug Delivery Systems

CytroCell Micronized Cellulose Enhances the Structural and Thermal Properties of IntegroPectin Cross-Linked Films

Food Waste-Derived Sources: Synthesis, Properties and Applications in Biomedical Engineering

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