Modulating the optical properties of carbon dots by peptide condensates

Gaash, Dor; Dewan, Simran; Leshem, Avigail Baruch; Jaiswal, Kumar Sagar; Jelinek, Raz; Lampel, Ayala

doi:10.1039/d3cc03945e

Chem. Commun.

2023

DOI: 10.1039/d3cc03945e

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Modulating the optical properties of carbon dots by peptide condensates

Dor Gaash,

Simran Dewan,

Avigail Baruch Leshem

et al.

Abstract: The fluorescence of tyrosine-carbon dots is modulated by their partitioning and release from peptide condensates.

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2024

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Cited by 5 publications

(1 citation statement)

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“…Several metabolite assemblies exhibit excellent optical properties, making them promising candidates for various bionanotechnological applications. − The optical properties of metabolites are related to forming structure-specific supramolecular fluorophores that allow for proton transfer via hydrogen bonding (Figure a). − Peptide nanotubes have been observed to exhibit strong photoluminescence in the blue and ultraviolet regions, which is due to excitons in the peptide nanotubes . Interestingly, FF monomers and FF nanotubes showed a remarkable difference in photoluminescence .…”

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confidence: 99%

Self-Assembly of Metabolite Nanostructures toward Functional Biomaterials

Zhang,

Zhou,

Jiang

et al. 2024

ACS Materials Lett.

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Metabolites have been developed for crystals with diverse morphologies and functionalities. These materials are self-assembled into various nanostructures, exhibiting excellent piezoelectric, semiconducting, optical, thermal, and mechanical properties. Due to the metabolites' excellent biocompatibility and biodegradability, the metabolite-based assemblies have found wide applications in wearable technologies, biomedical fields, and many other areas. In this paper, we review the synthesis methods and self-assembly mechanisms of metabolites and then discuss their versatile properties. We also highlight recent advances in energy harvesting, energy storage, and biomedical applications enabled by the metabolite self-assemblies and identify current challenges and potential directions of breakthroughs in studying metabolite assemblies.

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confidence: 99%

Self-Assembly of Metabolite Nanostructures toward Functional Biomaterials

Zhang,

Zhou,

Jiang

et al. 2024

ACS Materials Lett.

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Nanocomposite Hydrogels from Nanodiamonds and a Self‐Assembling Tripeptide

Marin,

Kralj,

Stehlik

et al. 2024

Chemistry A European J

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We report the successful assembly of a tripeptide in the presence of nanodiamonds (NDs) into nanocomposite hydrogels. The presence of NDs does not hinder peptide self‐assembly and gelation, whilst improving the viscoelastic properties of the hydrogels. Gelation kinetics are not affected by NDs, while the elastic moduli of the peptide hydrogels are significantly increased by the NDs. Increased resistance of the gels against applied stress can also be attained depending on the amount of NDs loaded in the nanocomposite. Raman micro‐spectroscopy and TEM confirmed the presence of NDs on the surface, and not in the interior, of peptide nanofibers. Peptide‐ND non‐covalent interactions are also probed by Raman and Fourier‐transformed infrared spectroscopies. Overall, this work enables the embedding of NDs into nanocomposite hydrogels formed through the self‐assembly of a simple tripeptide at physiological pH, and it provides key insights to open the way for their future applications in biomaterials, for instance exploiting their luminescence and near‐infrared responsiveness.

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Charge‐Mediated Interactions Affect Enzymatic Reactions in Peptide Condensates

Harris,

Berman,

Lampel

2024

ChemSystemsChem

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Biomolecular condensates, formed through liquid‐liquid phase separation (LLPS), serve as enzymatic reaction centers in cells by increasing local concentrations of enzymes and substrates, thereby facilitating reaction kinetics and regulatory mechanisms. Inspired by these natural systems, synthetic condensates are being developed for diverse applications, including payload delivery, sensing, and as microreactors where enzymatic reaction kinetics can be modulated by factors like pH, viscosity, and enzyme‐substrate co‐localization. Here, we investigate how the physicochemical properties of enzymes and substrates influence condensate formation and function as microreactors. Focusing on cellulase and alkaline phosphatase, which differ in molecular weight and isoelectric point, we employed a minimalistic complex coacervation system of oppositely charged LLPS‐promoting peptides. Our findings show how electrostatic forces within condensates influence their role as microreactors. Specifically, the ability of condensates to encapsulate or exclude phosphatase and cellulase and their substrates, which is pivotal for the regulation of reaction kinetics, is determined by the enzyme surface charge, substrate charge, and condensate charge stoichiometry. These results highlight the potential of utilizing electrostatic forces within condensates to modulate enzymatic reactions, providing critical insights for developing synthetic condensates as microreactors in biotechnology and materials science.

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Modulating the optical properties of carbon dots by peptide condensates

Abstract: The fluorescence of tyrosine-carbon dots is modulated by their partitioning and release from peptide condensates.

Cited by 5 publications

References 40 publications

Self-Assembly of Metabolite Nanostructures toward Functional Biomaterials

Self-Assembly of Metabolite Nanostructures toward Functional Biomaterials

Nanocomposite Hydrogels from Nanodiamonds and a Self‐Assembling Tripeptide

Charge‐Mediated Interactions Affect Enzymatic Reactions in Peptide Condensates

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