2023
DOI: 10.3389/fimmu.2023.1274223
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Modulating β-catenin/BCL9 interaction with cell-membrane-camouflaged carnosic acid to inhibit Wnt pathway and enhance tumor immune response

Ruqing Gao,
Xiaoqiang Zheng,
Aimin Jiang
et al.

Abstract: IntroductionLung adenocarcinoma (LUAD) therapies are plagued by insufficient immune infiltration and suboptimal immune responses in patients, which are closely associated with the hyperactive Wnt/β-catenin pathway. Suppressing this signaling holds considerable promise as a potential tumor therapy for LUAD, but Wnt suppressor development is hindered by concerns regarding toxicity and adverse effects due to insufficient targeting of tumors.MethodsWe have synthesized a tumor-specific biomimetic Wnt pathway suppre… Show more

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