Modulation by steroid hormones and other factors on the expression of aquaporin-1 and aquaporin-5

Skowrońska, Agnieszka; Tanski, Damian; Jaśkiewicz, Łukasz; Skowroński, Mariusz T.

doi:10.1016/bs.vh.2019.08.006

Cited by 6 publications

(1 citation statement)

References 109 publications

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“…AQPs 1, -2, -3, and -5 in the vagina are suggested to serve roles in tissue surface hydration [92], and in the uterus are proposed to maintain fluid homeostasis during peri-implantation and pregnancy [93,94]. Levels of AQP expression are dependent in part on hormonal signaling [93,95], controlled via steroid responsive promoters [96][97][98][99].…”

Section: Aquaporin Expression In Male and Female Reproductive Tissues And Cancersmentioning

confidence: 99%

Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers

Khan

Ricciardelli

Yool

2021

Cells

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Aquaporins are membrane channels in the broad family of major intrinsic proteins (MIPs), with 13 classes showing tissue-specific distributions in humans. As key physiological modulators of water and solute homeostasis, mutations, and dysfunctions involving aquaporins have been associated with pathologies in all major organs. Increases in aquaporin expression are associated with greater severity of many cancers, particularly in augmenting motility and invasiveness for example in colon cancers and glioblastoma. However, potential roles of altered aquaporin (AQP) function in reproductive cancers have been understudied to date. Published work reviewed here shows distinct classes aquaporin have differential roles in mediating cancer metastasis, angiogenesis, and resistance to apoptosis. Known mechanisms of action of AQPs in other tissues are proving relevant to understanding reproductive cancers. Emerging patterns show AQPs 1, 3, and 5 in particular are highly expressed in breast, endometrial, and ovarian cancers, consistent with their gene regulation by estrogen response elements, and AQPs 3 and 9 in particular are linked with prostate cancer. Continuing work is defining avenues for pharmacological targeting of aquaporins as potential therapies to reduce female and male reproductive cancer cell growth and invasiveness.

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Section: Aquaporin Expression In Male and Female Reproductive Tissues And Cancersmentioning

confidence: 99%

Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers

Khan

Ricciardelli

Yool

2021

Cells

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Comprehensive studies on the biological activities of human metastatic (MDA-MB-231) and non-metastatic (MCF-7) breast cancer cell lines, directly or combinedly treated using non-thermal plasma-based approaches

Terefinko,

Dzimitrowicz,

Bielawska-Pohl

et al. 2024

Toxicology in Vitro

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ARL13B controls male reproductive tract physiology through primary and Motile Cilia

Augière,

Campolina-Silva,

Vijayakumaran

et al. 2024

Commun Biol

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ARL13B is a small regulatory GTPase that controls ciliary membrane composition in both motile cilia and non-motile primary cilia. In this study, we investigated the role of ARL13B in the efferent ductules, tubules of the male reproductive tract essential to male fertility in which primary and motile cilia co-exist. We used a genetically engineered mouse model to delete Arl13b in efferent ductule epithelial cells, resulting in compromised primary and motile cilia architecture and functions. This deletion led to disturbances in reabsorptive/secretory processes and triggered an inflammatory response. The observed male reproductive phenotype showed significant variability linked to partial infertility, highlighting the importance of ARL13B in maintaining a proper physiological balance in these small ducts. These results emphasize the dual role of both motile and primary cilia functions in regulating efferent duct homeostasis, offering deeper insights into how cilia related diseases affect the male reproductive system.

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Modulation by steroid hormones and other factors on the expression of aquaporin-1 and aquaporin-5

Cited by 6 publications

References 109 publications

Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers

Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers

Comprehensive studies on the biological activities of human metastatic (MDA-MB-231) and non-metastatic (MCF-7) breast cancer cell lines, directly or combinedly treated using non-thermal plasma-based approaches

ARL13B controls male reproductive tract physiology through primary and Motile Cilia

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