Modulation of acute steroidogenesis, peroxisome proliferator-activated receptors and CYP3A/PXR in salmon interrenal tissues by tributyltin and the second messenger activator, forskolin

Pavlíková, Nela; Kortner, Trond M.; Arukwe, Augustine

doi:10.1016/j.cbi.2010.03.005

Cited by 24 publications

(14 citation statements)

References 59 publications

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“…Indeed, PPAR have been reported to modulate genes involved in cholesterol uptake and transport (32) , including StAR (33) , hence affecting steroid production in mammals (34) . Similar interactions between PPAR and StAR have recently been implicated in Atlantic salmon (Salmo salar) (35) .…”

mentioning

confidence: 64%

Teleost fish larvae adapt to dietary arachidonic acid supply through modulation of the expression of lipid metabolism and stress response genes

et al. 2011

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Dietary fatty acid supply can affect stress response in fish during early development. Although knowledge on the mechanisms involved in fatty acid regulation of stress tolerance is scarce, it has often been hypothesised that eicosanoid profiles can influence cortisol production. Genomic cortisol actions are mediated by cytosolic receptors which may respond to cellular fatty acid signalling. An experiment was designed to test the effects of feeding gilthead sea-bream larvae with four microdiets, containing graded arachidonic acid (ARA) levels (0·4, 0·8, 1·5 and 3·0 %), on the expression of genes involved in stress response (steroidogenic acute regulatory protein, glucocorticoid receptor and phosphoenolpyruvate carboxykinase), lipid and, particularly, eicosanoid metabolism (hormone-sensitive lipase, PPARa, phospholipase A 2 , cyclo-oxygenase-2 and 5-lipoxygenase), as determined by real-time quantitative PCR. Fish fatty acid phenotypes reflected dietary fatty acid profiles. Growth performance, survival after acute stress and similar whole-body basal cortisol levels suggested that sea-bream larvae could tolerate a wide range of dietary ARA levels. Transcription of all genes analysed was significantly reduced at dietary ARA levels above 0·4 %. Nonetheless, despite practical suppression of phospholipase A 2 transcription, higher leukotriene B 4 levels were detected in larvae fed 3·0 % ARA, whereas a similar trend was observed regarding PGE 2 production. The present study demonstrates that adaptation to a wide range of dietary ARA levels in gilthead sea-bream larvae involves the modulation of the expression of genes related to eicosanoid synthesis, lipid metabolism and stress response. The roles of ARA, other polyunsaturates and eicosanoids as signals in this process are discussed.

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confidence: 64%

Teleost fish larvae adapt to dietary arachidonic acid supply through modulation of the expression of lipid metabolism and stress response genes

et al. 2011

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“…Thus, although the selectivity of currently available FSK derivatives for defined AC isoforms is far from satisfying, proof of principle has been provided that ligand selectivity could be obtained, particularly by the introduction of large substituents. However, it should be kept in mind that FSK does not only bind to mACs but also to other important pharmacological targets such as glucose transporters, P-glycoprotein multidrug resistance transporters, ion channels, and nuclear receptors such as pregnane X receptor (Joost et al, 1988;Morris et al, 1991;Ding and Staudinger, 2005;Pavlikova et al, 2010;Kinast et al, 2012;AngelChavez et al, 2015). Such interactions of FSK are of concern for clinical application, specifically for longterm systemic treatment in conjunction with other drugs, increasing the risk of drug/drug interactions.…”

Section: Pharmacological Modulation Of Mammalian Adenylyl Cyclasesmentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Dessauer¹,

Watts²,

Ostrom³

et al. 2017

Pharmacol Rev

173

198

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“…Organotin compounds have also been reported to modulate the CYP biotransformation system, particularly the 3A family [60]. In the present study, cytochrome P450, family 3 (CYP3A), subfamily a, polypeptide 13 was found to be down-regulated 5.2 fold at 6 h and up-regulated 4.3 fold at 96 h. Pavlikova also reported that TBT produced effects on CYP3A mRNA of salmon that increased significantly at 0.1 mg/kg fish with diet force-fed after 72 h and decreased thereafter 1 and 10 mg/kg fish group [60]. The mRNA expression data from the present study demonstrated the involvement of CYP3A enzyme in possible TBT metabolism.…”

Section: Discussionmentioning

confidence: 99%

Gene expression profiling in respond to TBT exposure in small abalone Haliotis diversicolor

Jia

Zou

Wang

et al. 2011

Fish & Shellfish Immunology

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Modulation of acute steroidogenesis, peroxisome proliferator-activated receptors and CYP3A/PXR in salmon interrenal tissues by tributyltin and the second messenger activator, forskolin

Cited by 24 publications

References 59 publications

Teleost fish larvae adapt to dietary arachidonic acid supply through modulation of the expression of lipid metabolism and stress response genes

Teleost fish larvae adapt to dietary arachidonic acid supply through modulation of the expression of lipid metabolism and stress response genes

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases

Gene expression profiling in respond to TBT exposure in small abalone Haliotis diversicolor

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