Modulation of adiponectin as a potential therapeutic strategy

Lim, Soo; Quon, Michael J.; Koh, Kwang Kon

doi:10.1016/j.atherosclerosis.2014.01.051

Cited by 126 publications

(85 citation statements)

References 87 publications

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“…Therefore, various means should be employed in the treatment of HS, such as ensuring airway ventilation, providing endotracheal intubation and mechanical ventilation, and conducting immediate hemostasis (Ogaki et al, 2014;Zhao et al, 2014). Adiponectin (ADPN) has a pronounced effect on vascular endothelial function; thus, much attention has and should be paid to the relationship between ADPN and HS (Lim et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Correlation between adiponectin and hemorrhagic shock in mice

Gong

Yao

et al. 2016

Genet. Mol. Res.

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ABSTRACT. The aim of this study was to explore the relationship between adiponectin (ADPN) and hemorrhagic shock (HS) and the recovery after HS. This is significant for further understanding of the pathophysiological processes of HS and the development of better treatments. In total, 72 male C57BL/6 mice were assigned randomly to three groups: control, HS, and recovery (N = 24). The HS mouse model was constructed by hemorrhage of the carotid artery and recovery was achieved by tail vein injection of Ringer's solution. The level of ADPN in the peripheral blood of mice before and after recovery was detected by enzyme-linked immunosorbent assay. Compared to control, HS mice showed significantly decreased ADPN levels with the extension of HS time while the level of ADPN in recovery mice increased significantly and remained high. The variation of ADPN levels was closely associated with the occurrence of HS in mice and their recovery, suggesting that ADPN might act as a biomarker of inflammation and have potential for the treatment of HS.

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Section: Introductionmentioning

confidence: 99%

Correlation between adiponectin and hemorrhagic shock in mice

Gong

Yao

et al. 2016

Genet. Mol. Res.

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“…It was reported that APN played an important role in metabolic and cardiovascular homeostasis (Lim et al 2014). A meta-analysis showed that the higher APN levels, the lower cardiovascular events (Gasbarrino et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Elevated Plasma miR-29a Levels Are Associated with Increased Carotid Intima-Media Thickness in Atherosclerosis Patients

Liu

Zhong

Huang

2017

Tohoku J. Exp. Med.

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Atherosclerotic cardiovascular diseases, such as coronary heart disease, have become a major public health problem all over the world. MicroRNA-29a (miR-29a) modulates expression levels of collagen, inflammatory reaction and other extracellular matrix mRNAs, while adiponectin (APN), a circulating protein secreted by adipocytes, has anti-inflammatory properties. Both play multifaceted roles in angiogenesis or vascular remodelling. However, little is known about plasma miR-29a and APN levels in patients with atherosclerosis. We therefore investigated the relationship between the plasma levels of miR-29a or APN and carotid intima-media thickness (cIMT) in atherosclerosis patients (n = 85, cIMT ≥ 1.2 mm) and the controls (n = 85, cIMT < 1.2 mm). We found that the atherosclerosis group showed higher miR-29a levels (31.15 ± 3.99 vs. 26.39 ± 1.05 Ct, P < 0.001) and lower APN levels (15.93 ± 4.61 vs. 21.80 ± 7.74 ng/ml, P < 0.001), compared with control group. Thus, increased cIMT was associated with higher plasma miR-29a levels (r = 0.688, P < 0.001) and with lower plasma APN levels (r = −0.494, P < 0.001). Furthermore, multiple logistic regression analysis indicated that higher miR-29a levels (OR: 1.136, 95% CI: 1.042-1.240, P = 0.004) increased the risk for atherosclerosis, whereas higher APN levels appeared to be protective (OR: 0.122, 95% CI: 0.055-0.271, P < 0.001). The present study indicates that elevated miR-29a levels and reduced APN levels are associated with atherosclerosis.Keywords: adiponectin; atherosclerosis; carotid intima-media thickness; microRNA; miR-29a Tohoku J. Exp. Med., 2017 March, 241 (3), 183-188. © 2017 Tohoku University Medical Press IntroductionAtherosclerotic cardiovascular diseases such as coronary heart disease and stroke have become a major public health problem all over the world (Murray et al. 2012). It is necessary to detect atherosclerotic cardiovascular diseases at earlier stages. In recent decades, microRNAs (miRs) are short non-coding RNA able to bind specific sequences on target mRNAs, thereby modulating gene expression (Gaudet and Brisson 2015). They are involved in almost every aspect of cellular or biological processes, and dysregulation of miRs correlated with cardiovascular diseases, such as atherosclerosis ). MiR-29a was one of the members of the miR-29 family (Hysolli et al. 2016). The miR-29 family, modulating mRNA level of collagen, inflammatory reaction and other extracellular matrix genes, play a multifaceted role in tissue remodelling and vessels injury Bretschneider et al. 2016). It was reported that miR-29 were up-regulated in the region of the heart adjacent to a myocardial infarction (MI) (van Rooij et al. 2008). Among other miRs, circulating miR-29a levels may represent one of the new biomarkers which significantly correlate with cardiovascular diseases (Roncarati et al. 2014). In addition, a previous study showed that miR-29b was involved in vascular smooth muscle cell migration and proliferation by mediating an epigenetic mechanism (Chen et al. 2011), which wa...

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“…Adiponectin inhibits atherogenesis by suppressing the nuclear translocation of NF-κB lowering the endothelial synthesis of pro-inflammatory chemokine IL-8 (7). Additionally, adiponectin attenuates TNF-α-induced expression of adhesion molecules on vascular endothelial cells, preventing monocyte adhesion, the initial step of atherogenesis (16).…”

Section: Discussionmentioning

confidence: 99%

Anti-atherogenic properties of resveratrol: 4-week resveratrol administration associated with serum concentrations of SIRT1, adiponectin, S100A8/A9 and VSMCs contractility in a rat model

Wiciński

Malinowski

Węclewicz

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Resveratrol (3, 4', 5-trihydroxy-trans-stilbene) is a natural, non-flavonoid polyphenol that exerts protective properties against atherosclerosis-associated endothelial dysfunction and senescence. The present study aimed to assess the influence of resveratrol on vascular contractility and molecular factors including sirtuin-1 (SIRT1), adiponectin and calprotectin (S100A8/A9) that are considered to be important elements of atherogenesis. A total of 17 male rats were divided into a control and treatment group and administered resveratrol or a placebo. Pharmacometrics were performed on an isolated and perfused tail artery. Serum SIRT1, adiponectin and S100A8/A9 levels were quantified using an ELISA assay. The level of SIRT1 in the control and treatment groups at time 0 was 4.26 and 4.45 ng/ml, respectively. SIRT1 in the control and treatment groups following 2 weeks of treatment was 4.59 and 6.86 ng/ml, respectively (P<0.05) and following 4 weeks of treatment was 4.15 and 6.38 ng/ml, respectively (P<0.05). The level of adiponectin in the control and treatment groups at time 0 was 1.24 and 1.21 ng/ml, respectively. Following 2 weeks of treatment, the level of adiponectin in the control and treatment groups was 1.22 and 1.2 ng/ml, respectively (P>0.05) and following 4 weeks of treatment was 1.26 and 1.58 ng/ml, respectively (P<0.05). The S100A8/A9 level in control and treatment groups at time 0 was 0.39 and 0.33 ng/ml, respectively. The level of S100A8/A9 in control and treatment groups following 2 weeks of treatment was 0.37 and 0.35 ng/ml, respectively (P>0.05) and following 4 weeks of treatment was 0.34 and 0.32 ng/ml, respectively (P>0.05). EC 50 values obtained for phenylephrine in resveratrol-pretreated arteries were significantly higher than controls in the presence and absence of A7-hydrochloride (P<0.05). The results of the present study indicate a significant increase in the concentration of SIRT1 and adiponectin in the resveratrol-pretreated group (P<0.05). S100A8/A9 serum concentrations remained unchanged. Reactivity of resistant arteries was significantly reduced for resveratrol-pretreated vessels and this effect was partially independent of phosphodiesterase (PDE1). Additionally, there was a synergistic interaction observed between resveratrol and the PDE1 inhibitor.

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Modulation of adiponectin as a potential therapeutic strategy

Cited by 126 publications

References 87 publications

Correlation between adiponectin and hemorrhagic shock in mice

Correlation between adiponectin and hemorrhagic shock in mice

Elevated Plasma miR-29a Levels Are Associated with Increased Carotid Intima-Media Thickness in Atherosclerosis Patients

Anti-atherogenic properties of resveratrol: 4-week resveratrol administration associated with serum concentrations of SIRT1, adiponectin, S100A8/A9 and VSMCs contractility in a rat model

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