Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition

Fumoto, Katsumi; Takigawa-Imamura, Hisako; Sumiyama, Kenta; Kaneiwa, Tomoyuki; Kikuchi, Akira

doi:10.1242/dev.141325

Cited by 32 publications

(77 citation statements)

References 46 publications

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“…Surfactant protein C (SP‐C), a downstream target of Nkx2.1 and a marker of distal pulmonary epithelial cells, can be detected as early as E9.5 . At E14.5, during the pseudoglandular stage, columnar cells prevail in the distal parts of the lung . By E16.5, alveolar progenitor cells, club cells (formerly known as Clara cells), and ciliated cells are detected (Figure ) .…”

Section: Overview Of Embryonic Lung Developmentmentioning

confidence: 99%

“…At E14.5, during the pseudoglandular stage, columnar cells prevail in the distal parts of the lung . By E16.5, alveolar progenitor cells, club cells (formerly known as Clara cells), and ciliated cells are detected (Figure ) . Around E17.5, during the saccular stage, cuboidal and flat squamous cells appear .…”

Section: Overview Of Embryonic Lung Developmentmentioning

confidence: 99%

“…By E16.5, alveolar progenitor cells, club cells (formerly known as Clara cells), and ciliated cells are detected (Figure ) . Around E17.5, during the saccular stage, cuboidal and flat squamous cells appear . Transcriptomic analysis of distal epithelial cells at E18.5 revealed the presence of five different cell populations: club cells (uteroglobin + ), ciliated cells [forkhead box protein J1 (Foxj1 + )], nascent alveolar type (AT) 1 (podoplanin + ), and AT2 (SP‐C + ) cells, and an intermediate AT1/AT2 cell, the bipotential alveolar progenitor (BP), found at the tips of the branching epithelium (Figure ) .…”

Section: Overview Of Embryonic Lung Developmentmentioning

confidence: 99%

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Lung development and emerging roles for type 2 immunity

Loering

Cameron

Starkey

et al. 2019

The Journal of Pathology

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Lung development is a complex process mediated through the interaction of multiple cell types, factors and mediators. In mice, it starts as early as embryonic day 9 and continues into early adulthood. The process can be separated into five different developmental stages: embryonic, pseudoglandular, canalicular, saccular, and alveolar. Whilst lung bud formation and branching morphogenesis have been studied extensively, the mechanisms of alveolarisation are incompletely understood. Aberrant lung development can lead to deleterious consequences for respiratory health such as bronchopulmonary dysplasia (BPD), a disease primarily affecting preterm neonates, which is characterised by increased pulmonary inflammation and disturbed alveolarisation. While the deleterious effects of type 1-mediated inflammatory responses on lung development have been well established, the role of type 2 responses in postnatal lung development remains poorly understood. Recent studies indicate that type 2-associated immune cells, such as group 2 innate lymphoid cells and alveolar macrophages, are increased in number during postnatal alveolarisation. Here, we present the current state of understanding of the postnatal stages of lung development and the key cell types and mediators known to be involved. We also provide an overview of how stem cells are involved in lung development and regeneration, and the negative influences of respiratory infections.No conflicts of interest were declared. Recently, it has been shown that in mice, mechanical forces are involved in organ development by controlling the ratio of fixed and rotating spindles needed for normal

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Section: Overview Of Embryonic Lung Developmentmentioning

confidence: 99%

Section: Overview Of Embryonic Lung Developmentmentioning

confidence: 99%

Section: Overview Of Embryonic Lung Developmentmentioning

confidence: 99%

See 1 more Smart Citation

Lung development and emerging roles for type 2 immunity

Loering

Cameron

Starkey

et al. 2019

The Journal of Pathology

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“…Fumoto et al. 2016 ; Iber and Menshykau 2013 ; Lindenmayer 1968 ; Merks and Koolwijk 2009 ; Schatten et al. 2007 ) to our knowledge, this is the first agent-based model of kidney morphogenesis.…”

Section: Discussionmentioning

confidence: 80%

Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis

et al. 2018

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The adult mammalian kidney has a complex, highly-branched collecting duct epithelium that arises as a ureteric bud sidebranch from an epithelial tube known as the nephric duct. Subsequent branching of the ureteric bud to form the collecting duct tree is regulated by subcellular interactions between the epithelium and a population of mesenchymal cells that surround the tips of outgrowing branches. The mesenchymal cells produce glial cell-line derived neurotrophic factor (GDNF), that binds with RET receptors on the surface of the epithelial cells to stimulate several subcellular pathways in the epithelium. Such interactions are known to be a prerequisite for normal branching development, although competing theories exist for their role in morphogenesis. Here we introduce the first agent-based model of ex vivo kidney uretic branching. Through comparison with experimental data, we show that growth factor-regulated growth mechanisms can explain early epithelial cell branching, but only if epithelial cell division depends in a switch-like way on the local growth factor concentration; cell division occurring only if the driving growth factor level exceeds a threshold. We also show how a recently-developed method, “Approximate Approximate Bayesian Computation”, can be used to infer key model parameters, and reveal the dependency between the parameters controlling a growth factor-dependent growth switch. These results are consistent with a requirement for signals controlling proliferation and chemotaxis, both of which are previously identified roles for GDNF.Electronic supplementary materialThe online version of this article (10.1007/s00285-018-1208-z) contains supplementary material, which is available to authorized users.

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“…While there are many agent-based models of other branching systems (e.g. Fumoto et al (2016); ; Lindenmayer (1968); Merks & Koolwijk (2009) ;Schatten et al (2007)) to our knowledge, this is the first agent-based model of kidney morphogenesis. A significant advantage of our approach is that unlike spatially-averaged compartment-based methods (e.g.…”

Section: Discussionmentioning

confidence: 93%

Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis

Lambert

MacLean

Fletcher

et al. 2017

Preprint

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The adult mammalian kidney has a complex, highly-branched collecting duct epithelium that arises as a ureteric bud sidebranch from an epithelial tube known as the nephric duct. Subsequent branching of the ureteric bud to form the collecting duct tree is regulated by subcellular interactions between the epithelium and a population of mesenchymal cells that surround the tips of outgrowing branches. The mesenchymal cells produce glial cell-line derived neurotrophic factor (GDNF), that binds with RET receptors on the surface of the epithelial cells to stimulate several subcellular pathways in the epithelium. Such interactions are known to be a prerequisite for normal branching development, although competing theories exist for their role in morphogenesis. Here we introduce the first agent-based model of ex vivo kidney uretic branching. Through comparison with experimental data, we show that growth factor-regulated growth mechanisms can explain early epithelial cell branching, but only if epithelial cell division depends in a switch-like way on the local growth factor concentration; cell division occurring only if the driving growth factor level exceeds a threshold. We also show how a recently-developed method, "Approximate Approximate Bayesian Computation", can be used to infer key model parameters, and reveal the dependency between the parameters controlling a growth factordependent growth switch. These results are consistent with a requirement for signals controlling proliferation and chemotaxis, both of which are previously identified roles for GDNF.

show abstract

Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition

Cited by 32 publications

References 46 publications

Lung development and emerging roles for type 2 immunity

Lung development and emerging roles for type 2 immunity

Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis

Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis

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