2020
DOI: 10.1016/j.neuropharm.2020.108071
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Modulation of cholinergic activity through lynx prototoxins: Implications for cognition and anxiety regulation

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Cited by 14 publications
(10 citation statements)
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References 136 publications
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“…Our transcriptomic analysis revealed enhanced expression of GPI-anchored lynx prototoxin genes Ly6g6e , Lypd1 , and Lypd6b in Chrna5+ neurons (Fig 5). Lynx proteins are well known modulators of nicotinic receptor properties and trafficking (Anderson et al, 2020; Miwa, 2021), but most of the insight into their actions comes from heterologous cell systems, deletion, and overexpression experiments. Their effects on nicotinic receptors in their native environment is unclear.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Our transcriptomic analysis revealed enhanced expression of GPI-anchored lynx prototoxin genes Ly6g6e , Lypd1 , and Lypd6b in Chrna5+ neurons (Fig 5). Lynx proteins are well known modulators of nicotinic receptor properties and trafficking (Anderson et al, 2020; Miwa, 2021), but most of the insight into their actions comes from heterologous cell systems, deletion, and overexpression experiments. Their effects on nicotinic receptors in their native environment is unclear.…”
Section: Discussionmentioning
confidence: 99%
“…Recent studies have examined cell-type specific modulation of nicotinic receptors by different lynx prototoxins and the consequences for cortical development and cognition (Anderson et al, 2020; Demars and Morishita, 2014; Falk et al, 2021; Miwa, 2021). Here, we discovered endogenous lynx modulation of nicotinic properties relevant for attention in subplate neurons expressing Chrna5 .…”
Section: Introductionmentioning
confidence: 99%
“…[ 8 , 9 • ]; and Ref. [ 10 ]). Lynx1 has been shown to bind tightly to nAChRs in vitro [ 11 ] in vivo [ 12 • ], and to the invertebrate nAChR homolog, AChBP, at nM affinity [ 13 ].…”
Section: Complexes Of Nachrs With Lynx1 – An Allosteric Approachmentioning
confidence: 99%
“…In addition to effects on membranelocalized nAChRs, endogenous modulators may also affect the trafficking of nAChR subunits to the membrane via association in the endoplasmic reticulum (Nichols et al, 2014;Miwa et al, 2019). Moreover, different endogenous modulators have been found to preferentially interact with specific nAChR subtypes and to be expressed in a region-and cell-specific manner, allowing for a potential high specificity in their effects (George et al, 2017;Miwa et al, 2019;Anderson et al, 2020). For instance, RIC-3, the resistance inhibitors of cholinesterase 3, has been shown to increase α4 and β2 nAChR subunit protein expression, but not the assembly of these subunits into the α4β2 nAChR subtype (Dau et al, 2013).…”
Section: Endogenous Modulators Of Nicotinic Receptorsmentioning
confidence: 99%