Modulation of estrogen causes disruption of craniofacial chondrogenesis in Danio rerio

Cohen, Sarah P.; LaChappelle, Adam R.; Walker, Benjamin S; Lassiter, Christopher S.

doi:10.1016/j.aquatox.2014.03.028

Cited by 45 publications

(52 citation statements)

References 42 publications

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“…It might be resulted from the environmental influences such as nutrition, life style activities and occupational stresses (Charisi et al, 2011). It is possible that the estrogen hormone in females can inhibit bone growths as previously explained (Khosla et al, 2012;Cohen et al, 2014;Polur et al, 2015;Nicks et al, 2016). Therefore, this hormone may also affect the long growth of female clavicles as reported in various populations including Isan Thais (Table IV).…”

Section: Discussionmentioning

confidence: 98%

Morphometry of Isan-Thai Clavicles as a Guide for Sex Determination

et al. 2017

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Section: Discussionmentioning

confidence: 98%

Morphometry of Isan-Thai Clavicles as a Guide for Sex Determination

et al. 2017

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“…To optimize this quantitative analysis of malformations of the head skeleton, a variety of distances and angles were evaluated, expanding on a previously reported set evaluated with exposure to 17β-estradiol (Cohen et al 2014). The different phenotypes induced by the dithiocarbamates and the triazoles supported re-evaluation of the quantification of head skeleton malformation using these two apparently differently acting chemical classes.…”

Section: Discussionmentioning

confidence: 99%

“…The method was based on previous research (Cohen et al 2014; Kimmel et al 1998; van Boxtel et al 2010), which was adapted as follows. After 5dpf, embryos were euthanized by rapid cooling of the plates on ice.…”

Section: Methodsmentioning

confidence: 99%

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Head skeleton malformations in zebrafish (Danio rerio) to assess adverse effects of mixtures of compounds

Staal¹,

Meijer²,

Kris³

et al. 2018

Arch Toxicol

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The EU-EuroMix project adopted the strategy of the European Food Safety Authority (EFSA) for cumulative risk assessment, which limits the number of chemicals to consider in a mixture to those that induce a specific toxicological phenotype. These so-called cumulative assessment groups (CAGs) are refined at several levels, including the target organ and specific phenotype. Here, we explore the zebrafish embryo as a test model for quantitative evaluation in one such CAG, skeletal malformations, through exposure to test compounds 0–120 hpf and alcian blue cartilage staining at 120 hpf, focusing on the head skeleton. Reference compounds cyproconazole, flusilazole, metam, and thiram induced distinctive phenotypes in the head skeleton between the triazoles and dithiocarbamates. Of many evaluated parameters, the Meckel’s–palatoquadrate (M–PQ) angle was selected for further assessment, based on the best combination of a small confidence interval, an intermediate maximal effect size and a gentle slope of the dose–response curve with cyproconazole and metam. Additional test compounds included in the CAG skeletal malformations database were tested for M–PQ effects, and this set was supplemented with compounds associated with craniofacial malformations or cleft palate to accommodate otherwise organized databases. This additional set included hexaconazole, all-trans-retinoic acid, AM580, CD3254, maneb, pyrimethanil, imidacloprid, pirimiphos-methyl, 2,4-dinitrophenol, 5-fluorouracil, 17alpha-ethynylestradiol (EE2), ethanol, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), PCB 126, methylmercury, boric acid, and MEHP. Most of these compounds produced a dose–response for M–PQ effects. Application of the assay in mixture testing was provided by combined exposure to cyproconazole and TCDD through the isobole method, supporting that in this case the combined effect can be modeled through concentration addition.

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“…In addition, the influence of the genetic, cellular, and external environment can have significant impacts on craniofacial development. For instance, sex hormones have drastic effects on embryonic facial patterning (Cohen, et al 2014), juvenile development (Fujita, et al 2004; Marquez Hernandez, et al 2011; Verdonck, et al 1998), and bone remodeling at juvenile and adult stages (Frenkel, et al 2010; Nicks, et al 2010). The hardness of diet can also have a significant impact on craniofacial geometry (Genbrugge, et al 2011; Parsons, et al 2014; Swiderski and Zelditch 2013).…”

Section: The Limitations Of Induced Mutationsmentioning

confidence: 99%

Cichlid fishes as a model to understand normal and clinical craniofacial variation

Powder

Albertson

2016

Developmental Biology

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We have made great strides towards understanding the etiology of craniofacial disorders, especially for ‘simple’ Mendelian traits. However, the facial skeleton is a complex trait, and the full spectrum of genetic, developmental, and environmental factors that contribute to its final geometry remain unresolved. Forward genetic screens are constrained with respect to complex traits due to the types of genes and alleles commonly identified, developmental pleiotropy, and limited information about the impact of environmental interactions. Here, we discuss how studies in an evolutionary model – African cichlid fishes – can complement traditional approaches to understand the genetic and developmental origins of complex shape. Cichlids exhibit an unparalleled range of natural craniofacial morphologies that model normal human variation, and in certain instance mimic human facial dysmorphologies. Moreover, the evolutionary history and genomic architecture of cichlids make them an ideal system to identify the genetic basis of these phenotypes via quantitative trait loci (QTL) mapping and population genomics. Given the molecular conservation of developmental genes and pathways, insights from cichlids are applicable to human facial variation and disease. We review recent work in this system, which has identified lbh as a novel regulator of neural crest cell migration, determined the Wnt and Hedgehog pathways mediate species-specific bone morphologies, and examined how plastic responses to diet modulate adult facial shapes. These studies have not only revealed new roles for existing pathways in craniofacial development, but have identified new genes and mechanisms involved in shaping the craniofacial skeleton. In all, we suggest that combining work in traditional laboratory and evolutionary models offers significant potential to provide a more complete and comprehensive picture of the myriad factors that are involved in the development of complex traits.

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Modulation of estrogen causes disruption of craniofacial chondrogenesis in Danio rerio

Cited by 45 publications

References 42 publications

Morphometry of Isan-Thai Clavicles as a Guide for Sex Determination

Morphometry of Isan-Thai Clavicles as a Guide for Sex Determination

Head skeleton malformations in zebrafish (Danio rerio) to assess adverse effects of mixtures of compounds

Cichlid fishes as a model to understand normal and clinical craniofacial variation

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