Modulation of fear/anxiety responses, but not food intake, following α-adrenoceptor agonist microinjections in the nucleus accumbens shell of free-feeding rats

Kochenborger, Larissa; Zanatta, Débora; Berretta, Luigi Marins; Lopes, Ana Paula Fraga; Wunderlich, Bruna Luiza; Januário, Ana Cláudia; Neto, José Marino; Terenzi, Mariana Graciela; Paschoalini, Marta Aparecida; Faria, Moacir Serralvo

doi:10.1016/j.neuropharm.2011.08.019

Cited by 14 publications

(8 citation statements)

References 78 publications

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“…Head-dipping behavior was measured as potential repetitive behavior since it is a behavior that rodents engage in commonly while in the EPM [45][46][47][48] . This behavior may also be an indicator of anxiety-like state with some studies suggesting an anxiolytic 45,46 but others suggesting anxiogenetic state 47,48 . Thus, it is not fully clear at this point whether this behavioral change represents an increase in stereotypical behaviors or an indicator of anxiety-like state in these treated groups.…”

Section: Discussionmentioning

confidence: 99%

Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles

Javurek

Suresh

Spollen

et al. 2017

Sci Rep

104

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Due to their antimicrobial properties, silver nanoparticles (AgNPs) are being used in non-edible and edible consumer products. It is not clear though if exposure to these chemicals can exert toxic effects on the host and gut microbiome. Conflicting studies have been reported on whether AgNPs result in gut dysbiosis and other changes within the host. We sought to examine whether exposure of Sprague-Dawley male rats for two weeks to different shapes of AgNPs, cube (AgNC) and sphere (AgNS) affects gut microbiota, select behaviors, and induces histopathological changes in the gastrointestinal system and brain. In the elevated plus maze (EPM), AgNS-exposed rats showed greater number of entries into closed arms and center compared to controls and those exposed to AgNC. AgNS and AgNC treated groups had select reductions in gut microbiota relative to controls. Clostridium spp., Bacteroides uniformis, Christensenellaceae, and Coprococcus eutactus were decreased in AgNC exposed group, whereas, Oscillospira spp., Dehalobacterium spp., Peptococcaeceae, Corynebacterium spp., Aggregatibacter pneumotropica were reduced in AgNS exposed group. Bacterial reductions correlated with select behavioral changes measured in the EPM. No significant histopathological changes were evident in the gastrointestinal system or brain. Findings suggest short-term exposure to AgNS or AgNC can lead to behavioral and gut microbiome changes.

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Section: Discussionmentioning

confidence: 99%

Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles

Javurek

Suresh

Spollen

et al. 2017

Sci Rep

104

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“…Taken together, it is suggested that decreased ΔFosB and increased BDNF expression in the NAc may be a long-term consequence of MS stress in early life, possibly modulating the NAc neuronal function. The NAc neuronal function was suggested to be modulated by behavioral stress paradigm 24 , 25 and its dysfunction has been implicated in depression and anxiety disorders 22 , 23 , 26 , 27 . Indeed, increased BDNF signaling in the NAc has been reported in stress-induced models of depression 50 - 52 , and stress-induced depressive effects was blunted in mice over-expressing ΔFosB in striatum 53 .…”

Section: Discussionmentioning

confidence: 99%

“…Development of anhedonia, a core symptom of major depressive disorder, has been ascribed to dysfunction of the reward pathway, in which the NAc plays a pivotal role 22 , 23 . The NAc neurons are activated responding to behavioral stress paradigm 24 , 25 , and have been implicated in anxiety disorders 26 , 27 . The mesolimbic dopaminergic activity and the stress-induced activation of the NAc neurons were blunted in our male MS rats that showed anxiety and depression-like behaviors 13 , 28 .…”

Section: Introductionmentioning

confidence: 99%

Beneficial Effects of Highly Palatable Food on the Behavioral and Neural Adversities induced by Early Life Stress Experience in Female Rats

Kim¹,

Lee²,

Kim³

et al. 2015

Int. J. Biol. Sci.

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This study examined the effects of highly palatable food during adolescence on the psycho-emotional and neural disturbances caused by early life stress experience in female rats. Female Sprague-Dawley pups were separated from dam for 3 h daily during the first two weeks of birth (MS) or left undisturbed (NH). Half of MS females received free access to chocolate cookies in addition to ad libitum chow from postnatal day 28. Pups were subjected to the behavioral tests during young adulthood. The plasma corticosterone response to acute stress, ΔFosB and brain-derived neurotrophic factor (BDNF) levels in the brain regions were analyzed. Total caloric intake and body weight gain during the whole experimental period did not differ among the experimental groups. Cookie access during adolescence and youth improved anxiety-/depression-like behaviors by MS experience. ΔFosB expression was decreased, but BDNF was increased in the nucleus accumbens of MS females, and ΔFosB expression was normalized and BDNF was further increased following cookie access. Corticosterone response to acute stress was blunted by MS experience and cookie access did not improve it. Results suggest that cookie access during adolescence improves the psycho-emotional disturbances of MS females, and ΔFosB and/or BDNF expression in the nucleus accumbens may play a role in its underlying neural mechanisms.

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“…Indeed, both accumbal DA and accumbal noradrenaline were found not only to regulate locomotor activity (Pijnenburg et al, 1975; Costall et al, 1976; Cools et al, 1987; Ikeda et al, 2007; Verheij et al, accepted), sensorimotor gating (Alsene et al, 2010, 2011) and anxiety (Roozendaal and Cools, 1994; Kochenborger et al, 2012), but also more complex behaviors that are depending on learning and memory (Tuinstra et al, 2000, 2002; Kerfoot et al, 2008; Kerfoot and Williams, 2011) processes (for review: Verheij and Cools, 2008). …”

Section: Discussionmentioning

confidence: 99%

Noradrenaline-induced release of newly-synthesized accumbal dopamine: differential role of alpha- and beta-adrenoceptors

Meyer

Latour

Cools

et al. 2014

Front. Cell. Neurosci.

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Previous studies have shown that intra-accumbens infusion of isoproterenol (ISO), a beta-adrenoceptor-agonist, and phenylephrine (PE), an alpha-adrenoceptor-agonist, increase the release of accumbal dopamine (DA). In the present study we analyzed whether the ISO-induced release of DA is sensitive to pretreatment with the DA synthesis inhibitor alpha-methyl-para-tyrosine (AMPT). Earlier studies have shown that the PE-induced release of DA is derived from DA pools that are resistant to AMPT. In addition to PE, the alpha-adrenoceptor-antagonist phentolamine (PA) was also found to increase accumbal DA release. Therefore, we investigated whether similar to the DA-increasing effect of PE, the DA increase induced by PA is resistant to AMPT. Pretreatment with AMPT prevented the ISO-induced increase of accumbal DA. The accumbal DA increase after PA was not reduced by the DA synthesis inhibitor, independently of the amount of DA released. These results show that mesolimbic beta-, but not alpha-adrenoceptors, control the release of accumbal newly-synthesized DA pools. The DA-increasing effects of PE have previously been ascribed to stimulation of presynaptic receptors located on noradrenergic terminals, whereas the DA-increasing effects of PA and ISO have been ascribed to an action of these drugs at postsynaptic receptors on dopaminergic terminals. The fact that AMPT did not affect the accumbal DA response to PE and PA, whereas it did prevent the accumbal DA increase to ISO, supports our previously reported hypothesis that the noradrenergic neurons of the nucleus accumbens containing presynaptic alpha-adrenoceptors impinge upon the dopaminergic terminals in the nucleus accumbens containing postsynaptic adrenoceptors of the alpha but not of the beta type. The putative therapeutic effects of noradrenergic agents in the treatment of DA-related disorders are shortly discussed.

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Modulation of fear/anxiety responses, but not food intake, following α-adrenoceptor agonist microinjections in the nucleus accumbens shell of free-feeding rats

Cited by 14 publications

References 78 publications

Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles

Gut Dysbiosis and Neurobehavioral Alterations in Rats Exposed to Silver Nanoparticles

Beneficial Effects of Highly Palatable Food on the Behavioral and Neural Adversities induced by Early Life Stress Experience in Female Rats

Noradrenaline-induced release of newly-synthesized accumbal dopamine: differential role of alpha- and beta-adrenoceptors

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