2017
DOI: 10.1016/j.virol.2016.10.006
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Modulation of HCV replication and translation by ErbB3 binding protein1 isoforms

Abstract: We recently identified a cell-factor, ErbB3 binding protein 1 (Ebp-1), which specifically interacts with the viral RNA genome and modulates HCV replication and translation. Ebp1 has two isoforms, p48, and p42, that result from differential splicing. We found that both isoforms interact with HCV proteins NS5A and NS5B, as well as cell-factor PKR. The p48 isoform, which localizes in the cytoplasm and nuclei, promoted HCV replication, whereas the shorter p42 isoform, which resides exclusively in the cytoplasm, st… Show more

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Cited by 2 publications
(3 citation statements)
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References 53 publications
(77 reference statements)
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“…These interactions seem to change over the course of the HCV cycle, partially helping to explain SG oscillation and the current heterogeneity of results among studies . This complex interplay is coupled with PKR inhibition or modulation by several other mechanisms not related to SGs, leading us to state that the red line between an antiviral response and viral exploitation of host factors is extremely thin; both seem profoundly integrated.…”
Section: How Hcv Plays With P‐bodies and Sgs Without Getting Burnedmentioning
confidence: 99%
“…These interactions seem to change over the course of the HCV cycle, partially helping to explain SG oscillation and the current heterogeneity of results among studies . This complex interplay is coupled with PKR inhibition or modulation by several other mechanisms not related to SGs, leading us to state that the red line between an antiviral response and viral exploitation of host factors is extremely thin; both seem profoundly integrated.…”
Section: How Hcv Plays With P‐bodies and Sgs Without Getting Burnedmentioning
confidence: 99%
“…Rede de Interação 6,7,56,57,58,59,66,67,68,69,71,72 Regeneração Tecidual 86,88 Revisão Integrativa 81, 82, 83, 84…”
unclassified
“…H HCV 56,57,58,66,67,68,69,71,72,73,74,75,76,77,78,79 I IMC 29,30,31,34,36 incubans Macfie 95,96,99 Indústria Alimentícia 81 Inibidor 43,44,45,46,47,48,49,50,51,52…”
mentioning
confidence: 99%