Modulation of humoral and cell-mediated immune responses by dietary lutein in cats

Kim, Hong Wook; Chew, Boon P.; Wong, Teri S.; Park, Jean Soon; Weng, Bor-Chun; Byrne, Katherine; Hayek, Michael G.; Reinhart, Gregory A.

doi:10.1016/s0165-2427(00)00152-5

Cited by 76 publications

(48 citation statements)

References 16 publications

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“…Birds with almost depleted levels of carotenoids were capable of mounting similar primary and secondary anti-SRBC antibody titres and swelling responses to PHA as those circulating relatively high physiological doses of carotenoids. In this respect, our findings diverge from those of mammal studies (Jyonouchi et al, 1994;Kim et al, 2000a;Kim et al, 2000b), where lutein supplementation has been shown to enhance immunoglobulin (IgG) production and/or T-cell proliferation. In chickens, lutein supplementation affected PHA-stimulated lymphocyte proliferation (Selvaraj et al, 2006), whereas no effect of antibody production against KLH (Selvaraj et al, 2006) or Newcastle disease virus (Haq et al, 1996) was detected.…”

Section: Effects Of Carotenoid Supplementationcontrasting

confidence: 99%

Antioxidant protection, carotenoids and the costs of immune challenge in greenfinches

Hõrak

Zilmer

Saks

et al. 2006

Journal of Experimental Biology

101

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SUMMARY Costs accompanying immune challenges are believed to play an important role in life-history trade-offs and warranting the honesty of signal traits. We performed an experiment in captive greenfinches (Carduelis chlorisL.) in order to test whether and how humoral immune challenge with non-pathogenic antigen [sheep red blood cells (SRBC)] affects parameters of individual condition including intensity of coccidian infection, estimates of total antioxidant protection, plasma carotenoids and ability to mount a cell-mediated immune response. We also asked whether the potential costs of immune challenge can be alleviated by dietary carotenoid supplementation. None of the treatments affected intensity of coccidiosis. Humoral immune challenge suppressed the cell-mediated response to phytohemagglutinin (PHA), suggesting a trade-off between the uses of different arms of the immune system. Immune challenge reduced body-mass gain, but only among the carotenoid-depleted birds, indicating that certain somatic costs associated with immune system activation can be alleviated by carotenoids. No evidence for oxidative stress-induced immunopathological damages could be found because immune activation did not affect total antioxidant protection or carotenoid levels. Carotenoid supplementation inclined birds to fattening, indicating that lutein interfered with lipid metabolism. Altogether, our results support the hypotheses of biological importance of carotenoids and exemplify the overwhelming complexity of their integrated ecophysiological functions.

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Section: Effects Of Carotenoid Supplementationcontrasting

confidence: 99%

Antioxidant protection, carotenoids and the costs of immune challenge in greenfinches

Hõrak

Zilmer

Saks

et al. 2006

Journal of Experimental Biology

101

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“…Enhanced plasma IgG (p50.05; cats) (Kim et al 2000a(Kim et al , 2000b Glucosinolates 150 and 300 nM 1-5 phenolic, carotenoid and glucosinolate secondary metabolite compound classes have also been proven to modulate levels of cytokines, transcription factors and antioxidant enzymes (Table 2). In general, papaya extracts and papaya-associated phytochemicals have demonstrated some potential antiinflammatory and immunomodulatory activities.…”

Section: Anti-inflammatory Activities Of Papaya-associated Phytochemimentioning

confidence: 99%

Anti-inflammatory and immunomodulatory properties of Carica papaya

Pandey

Cabot

Shaw

et al. 2016

Journal of Immunotoxicology

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Chronic inflammation is linked with the generation and progression of various diseases such as cancer, diabetes and atherosclerosis, and anti-inflammatory drugs therefore have the potential to assist in the treatment of these conditions. Carica papaya is a tropical plant that is traditionally used in the treatment of various ailments including inflammatory conditions. A literature search was conducted by using the keywords ''papaya'', ''anti-inflammatory and inflammation'' and ''immunomodulation and immune'' along with cross-referencing. Both in vitro and in vivo investigation studies were included. This is a review of all studies published since 2000 on the antiinflammatory activity of papaya extracts and their effects on various immune-inflammatory mediators. Studies on the anti-inflammatory activities of recognized phytochemicals present in papaya are also included. Although in vitro and in vivo studies have shown that papaya extracts and papaya-associated phytochemicals possess anti-inflammatory and immunomodulatory properties, clinical studies are lacking. ARTICLE HISTORY

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“…In another study, KIM et al (2000b) evaluated the dietary supplementation of lutein in cats, and showed that in these animals, responses depend on both amount and time of supplementation. The authors observed an increase of both total lymphocyte proliferation and CD4+ and CD8+ production after four weeks of the highest level of lutein supplementation.…”

Section: Discussionmentioning

confidence: 99%

Dietary lutein supplementation on diet digestibility and blood parameters of dogs

et al. 2016

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Modulation of humoral and cell-mediated immune responses by dietary lutein in cats

Cited by 76 publications

References 16 publications

Antioxidant protection, carotenoids and the costs of immune challenge in greenfinches

Antioxidant protection, carotenoids and the costs of immune challenge in greenfinches

Anti-inflammatory and immunomodulatory properties of Carica papaya

Dietary lutein supplementation on diet digestibility and blood parameters of dogs

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