Modulation of Immune Response by Organophosphorus Pesticides: Fishes as a Potential Model in Immunotoxicology

Díaz-Reséndiz, Karina Janice Guadalupe; Toledo-Ibarra, Gladys Alejandra; Girón-Pérez, Manuel Iván

doi:10.1155/2015/213836

Cited by 56 publications

(31 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Increased level of nitric oxide under the influence of CPF may be attributed to that; fish body produces protective mechanism against the stress of pesticide. This result is in agreement with that obtained by Díaz-Resendiz et al [25] who reported increased production of nitric oxide significantly after exposure to pesticide. In addition, Xu et al [26] reported that CPF (1.16, 11.6 and 116 μg/L) induce an increase in the level of nitric oxide in C. carpio.…”

Section: The Chronic Toxicity Effect Of Chlorpyrifos On General Healtsupporting

confidence: 93%

“…After 30 days, the lysozyme level was significantly increased in groups 2 and 3, while there were no significant differences in group 4 compared to the control group. The lysozyme is one of the humoral innate immune factors; which is considered as a natural antibiotic of fish [25]. O. niloticus exposed to CPF at a rate of 0.102 and 0.255 mg/L revealed an increase in the activity of lysozyme level; but the lower concentration (0.051 mg/mL) of such pesticide did not produce any change on the lysozyme activity [26].…”

Section: The Chronic Toxicity Effect Of Chlorpyrifos On General Healtmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Insecticide "Chlorpyrifos" on Immune Response of Oreochromis niloticus

El‐Bouhy

El-Nobi

Reda

et al. 2016

Zagazig Veterinary Journal

View full text Add to dashboard Cite

This study was carried out to determine the level of Chlorpyrifos (CPF), an organophosphorus insecticide, in water of Abbassa and Sahl El-Hussinia fish farms and investigate the sub lethal concentration of this pesticide on immune response of Oreochromis niloticus (O. niloticus). Water samples were collected from Abbassa and Sahl El-Hussinia fish farms and analyzed using Gas chromatograph (GC) for detection of Chlorpyrifos level. Two hundred and ninety O. niloticus with average body weight (35±0.5 g) were collected from Abbassa fish hatchery, Sharkia Governorate, Egypt. One hundred and seventy of these fish were used for the determination of acute toxicity of Chlorpyrifos, while, another 120 fish were used for the determination of the effect of different sub lethal concentrations of Chlorpyrifos (1/8, 1/20 and 1/43 of 96 h LC 50) on the immune response of O. niloticus. It was found that; the levels of Chlorpyrifos in Abbassa and Sahl El-Hussinia fish farms were 0.008 and 0.0016 mg/L, respectively. The LC 50 value of Chlorpyrifos was 0.07mg/L. Sub-lethal concentration of Chlorpyrifos altered the non-specific immunological parameters (namely, total globulin, immunoglobulin M (IgM), lysozyme, nitric oxide, phagocytic activity) and interlukin-1β (IL-1β) of O. niloticus. It could be concluded that water of Abbassa and Sahl El-Hussinia fish farms have had detectable residue levels of CPF, which was altered the immunological status of O. niloticus.

show abstract

Section: The Chronic Toxicity Effect Of Chlorpyrifos On General Healtsupporting

confidence: 93%

Section: The Chronic Toxicity Effect Of Chlorpyrifos On General Healtmentioning

confidence: 99%

Effect of Insecticide "Chlorpyrifos" on Immune Response of Oreochromis niloticus

El‐Bouhy

El-Nobi

Reda

et al. 2016

Zagazig Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…The molecular mechanisms by which OPs activate immune cells remain largely unknown. There is evidence that OPs trigger nonneuronal cholinergic signaling of inflammatory cells (90,144,220), and mechanisms involving activation of signaling pathways by OP metabolites as well as OP-induced cytotoxicity/cell death of immune cells have also been implicated (56).…”

Section: Inflammatory Mechanisms Of Op-induced Ahrmentioning

confidence: 99%

Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma

Shaffo

Grodzki

Fryer

et al. 2018

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

Numerous epidemiologic studies have identified an association between occupational exposures to organophosphorus pesticides (OPs) and asthma or asthmatic symptoms in adults. Emerging epidemiologic data suggest that environmentally relevant levels of OPs may also be linked to respiratory dysfunction in the general population and that in utero and/or early life exposures to environmental OPs may increase risk for childhood asthma. In support of a causal link between OPs and asthma, experimental evidence demonstrates that occupationally and environmentally relevant OP exposures induce bronchospasm and airway hyperreactivity in preclinical models. Mechanistic studies have identified blockade of autoinhibitory M2 muscarinic receptors on parasympathetic nerves that innervate airway smooth muscle as one mechanism by which OPs induce airway hyperreactivity, but significant questions remain regarding the mechanism(s) by which OPs cause neuronal M2 receptor dysfunction and, more generally, how OPs cause persistent asthma, especially after developmental exposures. The goals of this review are to 1) summarize current understanding of OPs in asthma; 2) discuss mechanisms of OP neurotoxicity and immunotoxicity that warrant consideration in the context of OP-induced airway hyperreactivity and asthma, specifically, inflammatory responses, oxidative stress, neural plasticity, and neurogenic inflammation; and 3) identify critical data gaps that need to be addressed in order to better protect adults and children against the harmful respiratory effects of low-level OP exposures.

show abstract

“…Sin embargo, existen más de 60 artículos derivados de investigaciones ecotoxicológicas recientes realizadas en México en peces (i.e. Martínez-Tabche et al 1994, Dzul-Caamal et al 2012, Díaz-Resendiz et al 2015, Sánchez-Garayzar et al 2016, Toledo-Ibarra et al 2016 (Anguiano et al 2007(Anguiano et al , 2010 e insectos (Valdovinos-Núñez et al 2009, Pérez-Cogollo et al 2015. Dichos estudios relacionan exposición de OC, OF, CA, PS y herbicidas, con efectos en la salud de organismos de prueba.…”

Section: Estudios Ecotoxicológicosunclassified

Estado Actual De La Investigación Sobre Plaguicidas en México

Hernández

Leyva-Morales

Rodríguez

et al. 2018

Rev. Int. Contam. Ambie.

View full text Add to dashboard Cite

Palabras Clave: patrón de uso, exposición laboral, ecosistemas, contaminación, agricultura RESUMENEl presente trabajo analiza la investigación que se ha llevado a cabo en México con relación al uso y efecto de los plaguicidas en el ambiente y salud humana. Se revisaron 394 artículos publicados en los últimos 20 años en revistas indizadas o arbitradas. Las publicaciones se agruparon en 7 temas principales: 1) patrón de uso de plaguicidas, 2) efectos en el ambiente; 3) estudios ecotoxicológicos; 4) exposición en población humana; 5) residuos en alimentos; 6) toxicología de plaguicidas (estudios in vitro e in vivo); y 7) bioplaguicidas y biorremediación. El análisis de estas investigaciones indican que actualmente se utilizan Plaguicidas Altamente Peligrosos (PAPs) en las zonas agrícolas del país, su uso histórico y actual se relaciona con efectos negativos en ecosistemas terrestres y costeros, se han reportado efectos en la salud de los trabajadores agrícolas y sus familias, tales como alteraciones hematológicas, hormonales, daños genéticos, alteraciones del comportamiento y daños celulares; los niños constituyen el grupo más vulnerable a la exposición, además se han documentado daños genéticos, reproductivos y neuronales en modelos celulares y en organismos de laboratorio y se reportan residuos en alimentos como leche, hortalizas y granos. Como medidas de mitigación, se documentan procesos de biorremediación de suelos y agua contaminada,

show abstract

Modulation of Immune Response by Organophosphorus Pesticides: Fishes as a Potential Model in Immunotoxicology

Cited by 56 publications

References 58 publications

Effect of Insecticide "Chlorpyrifos" on Immune Response of Oreochromis niloticus

Effect of Insecticide "Chlorpyrifos" on Immune Response of Oreochromis niloticus

Mechanisms of organophosphorus pesticide toxicity in the context of airway hyperreactivity and asthma

Estado Actual De La Investigación Sobre Plaguicidas en México

Contact Info

Product

Resources

About