Modulation of integrin receptor by polyphenols: Downstream Nrf2-Keap1/ARE and associated cross-talk mediators in cardiovascular diseases

Fakhri, Sajad; Moradi, Seyed Zachariah; Nouri, Zeinab; Cao, Hui; Wang, Hui; Khan, Haroon; Xiao, Jianbo

doi:10.1080/10408398.2022.2118226

Cited by 11 publications

(2 citation statements)

References 243 publications

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“…Accordingly, the plant kingdom can pave the road to the construction of a successful treatment for CD and UC. Many in vitro and in vivo studies using phytocompounds as modulators of the Nrf2 signaling in IBD have already been published [ 15 , 16 ]. However, no existing review emphasizes the whole scenario for the potential of plants and phytocompounds as regulators of Nrf2 in IBD models and colitis-associated colorectal carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review

et al. 2023

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Inflammatory bowel diseases (IBDs) are related to nuclear factor erythroid 2-related factor 2 (Nrf2) dysregulation. In vitro and in vivo studies using phytocompounds as modulators of the Nrf2 signaling in IBD have already been published. However, no existing review emphasizes the whole scenario for the potential of plants and phytocompounds as regulators of Nrf2 in IBD models and colitis-associated colorectal carcinogenesis. For these reasons, this study aimed to build a review that could fill this void. The PubMed, EMBASE, COCHRANE, and Google Scholar databases were searched. The literature review showed that medicinal plants and phytochemicals regulated the Nrf2 on IBD and IBD-associated colorectal cancer by amplifying the expression of the Nrf2-mediated phase II detoxifying enzymes and diminishing NF-κB-related inflammation. These effects improve the bowel environment, mucosal barrier, colon, and crypt disruption, reduce ulceration and microbial translocation, and consequently, reduce the disease activity index (DAI). Moreover, the modulation of Nrf2 can regulate various genes involved in cellular redox, protein degradation, DNA repair, xenobiotic metabolism, and apoptosis, contributing to the prevention of colorectal cancer.

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Section: Introductionmentioning

confidence: 99%

Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review

et al. 2023

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“…Over the past three decades, a lot of research has been conducted on plant-derived phenolic compounds. Growing reports are showing the protective effects of polyphenols on major diseases such as cardiovascular disease [9], cancer [10], diabetes [11], obesity, and viral infections [12,13]. The potential role of polyphenols in modulating neurological disorders has been the focus of ongoing intensive efforts [14].…”

Section: Introductionmentioning

confidence: 99%

Quercetin Derivatives in Combating Spinal Cord Injury: A Mechanistic and Systematic Review

Fakhri

Gravandi

Abdian

et al. 2022

Life

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Spinal cord injury (SCI) possesses a complicated etiology. There is no FDA-approved treatment for SCI, and the majority of current interventions focus on reducing symptoms. During SCI, inflammation, oxidative stress, apoptosis, and autophagy are behind the secondary phase of SCI and cause serious consequences. It urges the need for providing multi-targeting agents, that possess lower side effects and higher efficacy. The plant secondary metabolites are multi-targeting agents and seem to provide new roads in combating diseases. Flavonoids are phytochemicals of continual interest to scientists in combating neurodegenerative diseases (NDDs). Flavonoids are being studied for their biological and pharmacological effects, particularly as antioxidants, anti-inflammatory agents, anti-apoptotic, and autophagy regulators. Quercetin is one of the most well-known flavonols known for its preventative and therapeutic properties. It is a naturally occurring bioactive flavonoid that has recently received a lot of attention for its beneficial effects on NDDs. Several preclinical evidence demonstrated its neuroprotective effects. In this systematic review, we aimed at providing the biological activities of quercetin and related derivatives against SCI. Detailed neuroprotective mechanisms of quercetin derivatives are also highlighted in combating SCI.

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Defining the mechanisms behind the hepatoprotective properties of curcumin

Yashmi,

Fakhri,

Shiri Varnamkhasti

et al. 2024

Arch Toxicol

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Modulation of integrin receptor by polyphenols: Downstream Nrf2-Keap1/ARE and associated cross-talk mediators in cardiovascular diseases

Cited by 11 publications

References 243 publications

Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review

Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review

Quercetin Derivatives in Combating Spinal Cord Injury: A Mechanistic and Systematic Review

Defining the mechanisms behind the hepatoprotective properties of curcumin

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