Modulation of intercellular Adhesion Molecule-1 Expression on Human Melanocytes and Melanoma Cells: Evidence for a Regulatory Role of IL-6, IL-7, TNFβ, and UVB Light

Kirnbauer, Reinhard; Charvat, Birgit; Schauer, E.; Köck, A; Urbanski, Agatha; Forster, Emanuel; Neuner, Peter; Assmann, Irene; Luger, Thomas A.; Schwarz, Thomas

doi:10.1111/1523-1747.ep12499793

Cited by 77 publications

(47 citation statements)

References 37 publications

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“…The regression of melanocytes during treatment with tocilizumab provides evidence for IL-6 and sIL-6R as future targets in the treatment of melanoma through its direct effect of melanocytic cytotoxicity supporting previous studies [7,8].…”

Section: Discussionsupporting

confidence: 84%

012. Halo Naevi, Vitiligo and Diffuse Alopecia Areata Associated with Tocilizumab Therapy

2015

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We present a follow-up case report of a 33-year-old lady with juvenile onset arthritis who developed halo naevi while on treatment with tocilizumab. This case report describes the development of halo naevi, vitiligo and diffuse alopecia areata associated with tocilizumab therapy following infection with Methicillin-resistant Staphylococcus aureus (MRSA) and Panton-Valentine leukocidin positivity. This is the first case that describes these events and supports previous theories on cellular and humoral immunity as causative factors. The regression of melanocytes during treatment with tocilizumab could also implicate IL-6 and sIL-6R as future targets in the treatment of melanoma through its direct effect of melanocytic cytotoxicity, which supports previous studies.

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Section: Discussionsupporting

confidence: 84%

012. Halo Naevi, Vitiligo and Diffuse Alopecia Areata Associated with Tocilizumab Therapy

2015

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“…5). Together they have a regulatory influence on cell-cell adhesion of melanocytes [61], but no data exist concerning the interaction between IL-6 and IL-7 for normal thyroid cells. In our experiments the cells secreted IL-7 only after 72 h on the RPM, while the corresponding 1 g -control cells did not secrete this cytokine at all.…”

Section: Discussionmentioning

confidence: 99%

Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine

Warnke

Pietsch

Kopp

et al. 2017

Cell Physiol Biochem

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Background/Aims: Spaceflight impacts on the function of the thyroid gland in vivo. In vitro normal and malignant thyrocytes assemble in part to multicellular spheroids (MCS) after exposure to the random positioning machine (RPM), while a number of cells remain adherent (AD). We aim to elucidate possible differences between AD and MCS cells compared to 1g-controls of normal human thyroid cells. Methods: Cells of the human follicular epithelial thyroid cell line Nthy-ori 3-1 were incubated for up to 72 h on the RPM. Afterwards, they were investigated by phase-contrast microscopy, quantitative real-time PCR and by determination of cytokines released in their supernatants. Results: A significant up-regulation of IL6, IL8 and CCL2 gene expression was found after a 4h RPM-exposure, when the whole population was still growing adherently. MCS and AD cells were detected after 24 h on the RPM. At this time, a significantly reduced gene expression in MCS compared to 1g-controls was visible for IL6, IL8, FN1, ITGB1, LAMA1, CCL2, and TLN1. After a 72 h RPM-exposure, IL-6, IL-8, and TIMP-1 secretion rates were increased significantly. Conclusion: Normal thyrocytes form MCS within 24 h. Cytokines seem to be involved in the initiation of MCS formation via focal adhesion proteins.

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“…For example, IL-6 has been shown to play a role in cell-to-cell adhesion and to increase breast carcinoma cell motility, which may influence metastatic potential [41]. IL-6 also upregulates melanocyte and melanoma cell expression of the in- tercellular adhesion molecule (ICAM)-1 [42], which has been correlated with increased risk of metastasis [43]. Borsellino et al [44] suggested that IL-6 may play a role in mediating PCA resistance to certain chemotherapeutic agents.…”

Section: Discussionmentioning

confidence: 99%

Characterization of the role of IL-6 in the progression of prostate cancer

et al. 1999

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Modulation of intercellular Adhesion Molecule-1 Expression on Human Melanocytes and Melanoma Cells: Evidence for a Regulatory Role of IL-6, IL-7, TNFβ, and UVB Light

Cited by 77 publications

References 37 publications

012. Halo Naevi, Vitiligo and Diffuse Alopecia Areata Associated with Tocilizumab Therapy

012. Halo Naevi, Vitiligo and Diffuse Alopecia Areata Associated with Tocilizumab Therapy

Cytokine Release and Focal Adhesion Proteins in Normal Thyroid Cells Cultured on the Random Positioning Machine

Characterization of the role of IL-6 in the progression of prostate cancer

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