Modulation of Lipoprotein Cholesterol Levels in Plasmodium berghei Malarial Infection by Crude Aqueous Extract of Ganoderma lucidum

Abstract

In this study, attempt is made to establish changes in serum and liver lipoprotein cholesterols accompanying Plasmodium berghei malarial infection in mice treated with aqueous extract of Ganoderma lucidum at 100, 250, and 500 mg/kg body weight in comparison with 15 mg/kg chloroquine (CQ). Significant increases in all the lipoprotein fractions were observed in infected untreated mice compared with normal control mice. Treatment with 100 and 250 mg/kg G. lucidum extract produced significant reduction in serum total cholesterol (TC) and low-density cholesterol (LDL-C) contents compared with 500 mg/kg G. lucidum and CQ. Treatment with CQ, however, produced significant reduction in hepatic TC and LDL-C compared with the extract. A dose-dependent significant increase in serum high-density lipoprotein cholesterol (HDL-C) was observed in the G. lucidum treated mice compared with normal control but significantly lower compared with CQ-treated mice. Liver HDL-C level was significantly higher in CQ-treated mice compared with normal control and significantly lower compared with G. lucidum-treated and infected untreated mice. A dose-dependent effect of the extract was observed in both serum and liver very-low density lipoprotein cholesterol (VLDL-C). The implication of these results is discussed with respect to the parasite survival and proliferation in the serum and liver.

Effect of vitamin A biofortification on the nutritional composition of cassava flour (gari) and evaluation of its glycemic index in healthy adults

“…It is envisaged that some valuable nutrients may have leached out at any of these processing stages (Akindahunsi et al, ). While low protein and ash contents of food may not be desirable due to their contributions to cellular growth and development and maintenance of healthy living, reduced fat level of food is noteworthy as foods with low‐fat content is usually recommended for diabetes and persons at high risk for cardiovascular diseases (CVD) (Oluba, Olusola, Eidangbe, Babatola, & Onyeneke, ). The percentage amylose fraction in the starch content for both white and yellow gari samples used in this study was high compared to the range of values (19.5–22.4%) obtained for five different cassava cultivars by Charles, Chang, Ko, Sriroth, and Huang () and the observed amylose: amylopectin ratio were far higher than the values reported for cassava by Nwokocha, Aviara, Senan, and Williams ().…”

The role of Schistosoma Haematobium in alteration of serum lipid profile among Sudanese schoolchildren

“…This reduction in total cholesterol level could also be contributedin reduction of the mean levels of LDL-C and HDL-C in same patient. The positive relationship between total cholesterol, LDL-C and HDL-C has been widely reported even in normal individuals [14]. The reason for the low triglyceride level in infected subjects is unclear but Sturrock et al [15] had demonstrated that S. mansoni is capable to obtain phospholipids and triglyceride from the host.…”

The good, the bad and the tasty: The many roles of mushrooms

“…Studies using mouse models, for example, have demonstrated the hypoglycaemic (Xiao et al. 2012) and LDL-cholesterol lowering (Oluba et al. 2012) effects of Ganoderma extracts.…”