2021
DOI: 10.3390/ncrna7030057
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Modulation of MicroRNA Processing by Dicer via Its Associated dsRNA Binding Proteins

Abstract: MicroRNAs (miRNAs) are small non-coding RNAs that are about 22 nucleotides in length. They regulate gene expression post-transcriptionally by guiding the effector protein Argonaute to its target mRNA in a sequence-dependent manner, causing the translational repression and destabilization of the target mRNAs. Both Drosha and Dicer, members of the RNase III family proteins, are essential components in the canonical miRNA biogenesis pathway. miRNA is transcribed into primary-miRNA (pri-miRNA) from genomic DNA. Dr… Show more

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Cited by 34 publications
(22 citation statements)
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References 119 publications
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“…MicroRNAs (miRNAs, also known as miRs) are a group of small single-stranded noncoding RNA (ncRNA) with approximately 18-22 nucleotides; miRNAs regulate gene expression by binding to the 3 -untranslated region (3 UTR) of the messenger RNA (mRNA) of a target gene, enhancing its degradation and/or inhibiting protein translation [1][2][3].…”
Section: Introductionmentioning
confidence: 99%
“…MicroRNAs (miRNAs, also known as miRs) are a group of small single-stranded noncoding RNA (ncRNA) with approximately 18-22 nucleotides; miRNAs regulate gene expression by binding to the 3 -untranslated region (3 UTR) of the messenger RNA (mRNA) of a target gene, enhancing its degradation and/or inhibiting protein translation [1][2][3].…”
Section: Introductionmentioning
confidence: 99%
“…The selective enrichment of miRNAs, which is abundant among small RNA families that are encapsulated in exosomes, depends on their size, origin, and transcription by RNA polymerase III [67][68][69][70]. miRNAs are transcribed by RNA polymerase (Pol) II into primary miR-NAs, which Drosha/DGCR8 processes into precursor miRNAs [71][72][73][74]. The pre-miRNA is transported from the nucleus into the cytoplasm by exportin 5 and then processed by Dicer/TRBP into an miRNA duplex [75][76][77].…”
Section: Proteins Peptides Lipid and Nucleic Acids In Exosomesmentioning
confidence: 99%
“…Unlike siRNA, shRNA requires further processing. Before further processing, shRNAs are initially processed by Drosha (a ribonuclease III enzyme) along with its dsRNA-binding partner DGCR8 to form substances referred to pre-shRNAs [17]. These substances are then transported to the cytoplasm with the aid of a protein called exportin 5 [16].…”
Section: Rna Interference (Mirna Shrna and Sirna)mentioning
confidence: 99%