Modulation of Peripheral and Central Auditory Processing by Estrogens in Birds

Caras, Melissa L.; Remage‐Healey, Luke

doi:10.1007/978-3-319-26597-1_4

Cited by 11 publications

(10 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Two thirds of the FoxP2-positive sites express androgen (AR) and/or estrogen (ERα, ERβ1, and ERβ2) receptors or the enzyme aromatase (estrogen synthase) that converts testosterone to estrogen [ Table 1; see Forlano and Bass, 2011, for review]. Together with studies in avian species showing the expression of steroid-signaling pathways in the auditory and song control systems [e.g., Ball et al, 2004;Caras and Remage-Healey, 2016], these findings suggest a more phylogenetically widespread functional relationship between steroid-signaling pathways and FoxP2 that is worthy of further investigation.…”

Section: Discussionmentioning

confidence: 99%

FoxP2 Expression in a Highly Vocal Teleost Fish with Comparisons to Tetrapods

Pengra

Marchaterre

Bass³

2018

Brain Behav Evol

View full text Add to dashboard Cite

Motivated by studies of speech deficits in humans, several studies over the past two decades have investigated the potential role of a forkhead domain transcription factor, FoxP2, in the central control of acoustic signaling/vocalization among vertebrates. Comparative neuroanatomical studies that mainly include mammalian and avian species have mapped the distribution of FoxP2 expression in multiple brain regions that imply a greater functional significance beyond vocalization that might be shared broadly across vertebrate lineages. To date, reports for teleost fish have been limited in number and scope to nonvocal species. Here, we map the neuroanatomical distribution of FoxP2 mRNA expression in a highly vocal teleost, the plainfin midshipman (Porichthys notatus). We report an extensive overlap between FoxP2 expression and vocal, auditory, and steroid-signaling systems with robust expression at multiple sites in the telencephalon, the preoptic area, the diencephalon, and the midbrain. Label was far more restricted in the hindbrain though robust in one region of the reticular formation. A comparison with other teleosts and tetrapods suggests an evolutionarily conserved FoxP2 phenotype important to vocal-acoustic and, more broadly, sensorimotor function among vertebrates.

show abstract

Section: Discussionmentioning

confidence: 99%

FoxP2 Expression in a Highly Vocal Teleost Fish with Comparisons to Tetrapods

Pengra

Marchaterre

Bass³

2018

Brain Behav Evol

View full text Add to dashboard Cite

show abstract

“…Administration of fadrozole, an aromatase inhibitor, blocks the modulatory effects of hCG on ERG thresholds in females, leaving those thresholds at untreated, non-reproductive levels. Endocrine modulation of reproductive behavior, including communication and sensory processing, is well known ( Yamaguchi and Kelly 2003 ; Arch and Narins 2009 ; Leary 2009 ; Maruska and Sisneros 2015 ; Caras and Remage-Healey 2016 ; Wilczynski and Burmeister 2016 ). Whether or not such modulation is based on changes in mechanisms mediating motivation and/or stimulus sensitivity is often difficult to untangle, as large areas of central and peripheral circuitry may be targets of modulation ( Caras 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Estrogenic Modulation of Retinal Sensitivity in Reproductive Female Túngara Frogs

Leslie

Walkowski

Rosencrans

et al. 2021

Integrative and Comparative Biology

View full text Add to dashboard Cite

Although mate searching behavior in female túngara frogs (Physalaemus pustulosus) is nocturnal and largely mediated by acoustic cues, male signaling includes visual cues produced by the vocal sac. To compensate for these low light conditions, visual sensitivity in females is modulated when they are in a reproductive state, as retinal thresholds are decreased. This study tested whether estradiol (E2) plays a role in this modulation. Female túngara frogs were injected with either human chorionic gonadotropin (hCG) or a combination of hCG and fadrozole. hCG induces a reproductive state and increases retinal sensitivity, while fadrozole is an aromatase inhibitor that blocks hCG-induced E2 synthesis. In an analysis of scotopic electroretinograms (ERGs), hCG treatment lowered the threshold for eliciting a b-wave response, whereas the addition of fadrozole abolished this effect, matching thresholds in non-reproductive saline-injected controls. This suggests that blocking E2 synthesis blocked the hCG-mediated reproductive modulation of retinal sensitivity. By implicating E2 in control of retinal sensitivity, our data add to growing evidence that the targets of gonadal steroid feedback loops include sensory receptor organs, where stimulus sensitivity may be modulated, rather than more central brain nuclei, where modulation may affect mechanisms involved in motivation.

show abstract

“…E2 signaling within NCM has been shown to be important for regulating associative learning and incentive saliency. [191][192][193][194] Intriguingly, E2 signaling also appears to modulate the saliency of acoustic signals in the auditory cortex and within the inner ear itself. 193,195,196…”

Section: Enduring Effects Of Pair Bonding On Auditory Perceptionmentioning

confidence: 99%

Reciprocal processes of sensory perception and social bonding: an integrated social‐sensory framework of social behavior

Prior

Bentz

Ophir

2021

Genes Brain and Behavior

View full text Add to dashboard Cite

Organisms filter the complexity of natural stimuli through their individual sensory and perceptual systems. Such perceptual filtering is particularly important for social stimuli.A shared "social umwelt" allows individuals to respond appropriately to the expected diversity of cues and signals during social interactions. In this way, the behavioral and neurobiological mechanisms of sociality and social bonding cannot be disentangled from perceptual mechanisms and sensory processing. While a degree of embeddedness

show abstract

Modulation of Peripheral and Central Auditory Processing by Estrogens in Birds

Cited by 11 publications

References 89 publications

FoxP2 Expression in a Highly Vocal Teleost Fish with Comparisons to Tetrapods

FoxP2 Expression in a Highly Vocal Teleost Fish with Comparisons to Tetrapods

Estrogenic Modulation of Retinal Sensitivity in Reproductive Female Túngara Frogs

Reciprocal processes of sensory perception and social bonding: an integrated social‐sensory framework of social behavior

Contact Info

Product

Resources

About