1995
DOI: 10.1007/bf01782258
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Modulation of polymorphonuclear leukocyte responsiveness by copper (II)2 (niflumate)4

Abstract: Antiinflammatory activities and modulations of PMNL responses produced by treatment with tetrakis-mu-2-[3-(trifluoromethyl)-phenyl]aminonicotinatodicopper (II) [Cu(II)2(niflumate)4] and niflumic acid were studied in isologous serum-induced rat pleurisy. Doses of 10 or 30 mg/kg (35 or 106 mumol/kg) of niflumic acid or Cu(II)2(niflumate)4 (8 or 23 mumol/kg) caused significant (p < 0.01) reductions in pleural exudate and number of polymorphonuclear leukocytes (PMNLs) in the exudate. While both doses of Cu(II)2(ni… Show more

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Cited by 8 publications
(4 citation statements)
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“…NFA-treated PMNs did not have selective inhibition to one stimulus but displayed a more globally impaired phenotype. Inhibitory effects of niflumic acid on chemotaxis of rat PMNs have previously been demonstrated using Boyden chamber measurements (31). The processes of chemotaxis and transendothelial migration inherently require significant shape change as a PMN that is near spherical in the resting state elongates to move along a directional gradient and move between adjacent endothelial cells.…”
Section: Discussionmentioning
confidence: 98%
See 1 more Smart Citation
“…NFA-treated PMNs did not have selective inhibition to one stimulus but displayed a more globally impaired phenotype. Inhibitory effects of niflumic acid on chemotaxis of rat PMNs have previously been demonstrated using Boyden chamber measurements (31). The processes of chemotaxis and transendothelial migration inherently require significant shape change as a PMN that is near spherical in the resting state elongates to move along a directional gradient and move between adjacent endothelial cells.…”
Section: Discussionmentioning
confidence: 98%
“…However, female carriers of chronic granulomatous disease who are obligate heterozygotes for the membrane component of the NADPH oxidase demonstrate reduced levels of NADPH oxidase activity in vitro, but have no increased susceptibility to infection as long as they have ϳ10% normal phagocytes (31). We reasoned that, despite the reduction in NADPH oxidase activity in NFA-treated human PMNs and in Clcn3 (Ϫ/Ϫ) PMNs, levels of ROS would still be adequate for bacterial killing in vitro.…”
Section: Expression Of Clc-3 Protein Inmentioning
confidence: 99%
“…The ability to cycle between +1 and +2 oxidation states of copper is one of the main features that has been exploited in biological systems. [12][13][14] Depending on the nature of the complex associated with copper, diverse cellular response has been elucidated. Perturbation in distinct mode of cell survival signal or induction of specific pathways associated with cell dismissal has been shown to induce by the copper-complex in vitro.…”
Section: Introductionmentioning
confidence: 99%
“…2) Different synthetic organic or biologically derived copper containing molecules, ceruloplasmin and yeast Cu(I)-thionein included, can decrease some rat or human neutrophil functions such as the chemotactic response [15,16], the superoxide anion generation [17][18][19][20] and the endothelial adhesion [19]. In contrast, the exposure of human polymorphonuclear leukocytes to Cu(II) chloride enhances the fMLP-induced cell migration [21].…”
Section: Introductionmentioning
confidence: 99%