Modulation of proteome expression by F-type lectin during viral hemorrhagic septicemia virus infection in fathead minnow cells

Cho, Se-Young; Kwon, Joseph; Vaidya, Bipin; Kim, Jong‐Oh; Lee, Sung-Hoon; Jeong, Eun-Hye; Baik, Keun Sik; Choi, Jong‐Soon; Bae, Hyeun‐Jong; Oh, Myung‐Joo; Kim, Duwoon

doi:10.1016/j.fsi.2014.05.042

Cited by 14 publications

(8 citation statements)

References 48 publications

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“…In region c, proinflammatory factors (IL-1β and CCR6) and T cell markers (CD3 and CD8) indicated CTL responses occurred in the inflammatory gut49; and F-type lectin was in line with other reports of fish inflammation5051. In region g, IL-17D might indicate Th17 response, since that IL-17D triggers secretion of IL-6 (the typical Th17 type cytokine)52; CD93 (C1qR) could facilitate phagocytosis53; and CD244 could probably mediate activation of NK-like cell54.…”

Section: Discussionsupporting

confidence: 87%

Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies

Song

Wang

et al. 2016

Sci Rep

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The gut-associated lymphoid tissue, connected with liver via bile and blood, constructs a local immune environment of both defense and tolerance. The gut-liver immunity has been well-studied in mammals, yet in fish remains largely unknown, even though enteritis as well as liver and gallbladder syndrome emerged as a limitation in aquaculture. In this study, we performed integrative bioinformatic analysis for both transcriptomic (gut and liver) and proteomic (intestinal mucus and bile) data, in both healthy and infected tilapias. We found more categories of immune transcripts in gut than liver, as well as more adaptive immune in gut meanwhile more innate in liver. Interestingly reduced differential immune transcripts between gut and liver upon inflammation were also revealed. In addition, more immune proteins in bile than intestinal mucus were identified. And bile probably providing immune effectors to intestinal mucus upon inflammation was deduced. Specifically, many key immune transcripts in gut or liver as well as key immune proteins in mucus or bile were demonstrated. Accordingly, we proposed a hypothesized profile of fish gut-liver immunity, during either homeostasis or inflammation. Current data suggested that fish gut and liver may collaborate immunologically while keep homeostasis using own strategies, including potential unique mechanisms.

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Section: Discussionsupporting

confidence: 87%

Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies

Song

Wang

et al. 2016

Sci Rep

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“…In these cases, recombinant galectin-1 ameliorated the cell viability of rock bream heart cells infected with RBIV and FHM cells infected with VHSV (Thulasitha et al 2016). Another rock bream lectin, a fucose-binding type lectin (F-type lectin), was found to block the effects of VHSV in FHM cells (Cho et al 2014). Cells transfected with an expression plasmid encoding rock bream F-type lectin-3 and then infected with VHSV showed higher viability compared to cells transfected with an empty plasmid (Cho et al 2014).…”

Section: Lectinsmentioning

confidence: 96%

“…Cells transfected with an expression plasmid encoding rock bream F‐type lectin‐3 and then infected with VHSV showed higher viability compared to cells transfected with an empty plasmid (Cho et al . 2014).…”

Section: Fish and Non‐piscine Immune Proteinsmentioning

confidence: 99%

Compilation of antiviral treatments and strategies to fight fish viruses

Pereiro

Figueras

Novoa

2020

Reviews in Aquaculture

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The implementation of antiviral treatments and prophylaxis strategies in fish aquaculture needs to be established. The absence of commercial vaccines for most viral diseases affecting economically relevant fish species, and the total lack of treatments to fight these diseases once they have emerged in a fish farm remains one of the main bottlenecks in fish aquaculture production. However, although no antivirals are currently applied on farms, a great number of investigations have been conducted to assess the potential use of antiviral treatments against several fish viruses. Although most of these works were based on in vitro approaches, some included in vivo experiments to demonstrate the potential applicability of these treatments. This review summarizes the investigations conducted both in vitro and in vivo in the field of antiviral treatments against fish viruses. The highlighted works include those using piscine and non-piscine proteins with antimicrobial functions, metabolites, chemical compounds (some of which are used in medicine to treat human viruses), bioactive compounds mainly isolated from plants and bacteria, and emerging DNA-and RNA-based therapeutics. This information can be used for developing both specific and broad-spectrum antiviral strategies to be further used in the aquaculture industry, and it may even provide interesting indications for biomedical research.

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“…Lectins also have roles in the protection against viruses; an F-type lectin, RbFTL-3, from rock bream ( Oplegnathus fasciatus ), mainly expressed in the intestine in the animal, could protect fathead minnow cells from hemorrhagic septicemia virus infection in vitro [ 40 ]. A proteomics study of RbFTL-3, showed that transfected and hence protected cells, showed interesting changes in proteins related to viral budding (SNF8, CCT5, and TUBB) and in thrombin signaling, compared to control cells [ 40 ].…”

Section: The Role Of Mucosal Lectins In Growth Inhibition and Killmentioning

confidence: 99%

Functional Aspects of Fish Mucosal Lectins—Interaction with Non-Self

et al. 2018

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Mucosal surfaces are of key importance in protecting animals against external threats including pathogens. In the mucosal surfaces, host molecules interact with non-self to prevent infection and disease. Interestingly, both inhibition and stimulation of uptake hinder infection. In this review, the current knowledgebase on teleost mucosal lectins’ ability to interact with non-self is summarised with a focus on agglutination, growth inhibition, opsonisation, cell adhesion, and direct killing activities. Further research on lectins is essential, both to understand the immune system of fishes, since they rely more on the innate immune system than mammals, and also to explore these molecules’ antibiotic and antiparasitic activities against veterinary and human pathogens.

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Modulation of proteome expression by F-type lectin during viral hemorrhagic septicemia virus infection in fathead minnow cells

Cited by 14 publications

References 48 publications

Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies

Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies

Compilation of antiviral treatments and strategies to fight fish viruses

Functional Aspects of Fish Mucosal Lectins—Interaction with Non-Self

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