Modulation of Radiation-Induced Alterations in Oxidative Stress and Cytokine Expression in Lung Tissue by<i>Panax Ginseng</i>Extract

Jang, Seong Soon; Kim, Hyeong Geug; Han, Jong Min; Lee, Jin Seok; Choi, Min Kyung; Huh, Gil Ja; Son, Chang Gue

doi:10.1002/ptr.5223

Cited by 19 publications

(12 citation statements)

References 33 publications

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“…IR induces the production of ROS and the excessive accumulation of ROS causes oxidative damage in lung tissues ( 7 , 22 , 23 ). ROS-induced oxidative damage in lung tissues might be one of the origin of inflammatory cell infiltration and imbalance of inflammatory cytokines.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Nuclear Factor-Erythroid 2-Related Factor 2 Against Radiation-Induced Lung Injury and Inflammation

et al. 2018

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Radiation-induced lung injury (RILI) is one of the most common and fatal complications of thoracic radiotherapy. Inflammatory cell infiltration, imbalance of inflammatory cytokines, and oxidative damage were reported to be involved during RILI pathogenesis, especially in the early phase of RILI. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator of antioxidative cascades, and regulates life span of mice after administration of thoracic irradiation. We investigated the effects of Nrf2 on RILI and inflammation using Nrf2-knockout, Nrf2-overexpression and wild-type mice with or without 15 Gy ionizing radiation to thorax. Our results showed that Nrf2 deficiency aggravated radiation-induced histopathological changes, macrophage and neutrophil infiltration, serum levels of pro-inflammatory cytokines (IL-6, MCP-1, IFN-γ, TNF, and IL-12p70), and the levels of peroxidation products in the mouse lung. Moreover, loss of Nrf2 reduced radiation-induced serum levels of anti-inflammatory cytokine, IL-10, and antioxidative proteins. Nrf2 overexpression significantly alleviated radiation-induced histopathological changes, macrophages and neutrophils infiltration, serum levels of pro-inflammatory cytokines, and the levels of peroxidation products in lung tissues. Nrf2 overexpression also increased the serum levels of IL-10 and antioxidative proteins. These results indicated that Nrf2 had a protective role against radiation-induced acute lung injury and inflammation, and that antioxidative therapy might be a promising treatment for RILI.

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Section: Discussionmentioning

confidence: 99%

Protective Role of Nuclear Factor-Erythroid 2-Related Factor 2 Against Radiation-Induced Lung Injury and Inflammation

et al. 2018

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“… Hong et al [ 164 ] TNF-α, TGF-β1 C57Bl/6 Thorax X-ray/15 Gy 2 and 10 d ELISA, RT-PCR Lung tissue mRNA expression and protein levels of TNF-α and TGF-β1 at 10 d after irradiation were significantly increased compared with control group. Jang et al [ 165 ] IL1-β, IL-4, TNF-α, EGF, TGF-β, IL-6 TGF-α C57BL/6 , C57BL/6 T NF –/– Thorax X-ray/5 × 6 Gy 2, 4, 8 and 20 w ELISA Lung tissue IL-1β, IL-6 and TNF-α concentration increased from baseline as early 2 w. No variations in IL-4 or EGF at any time after irradiation were noted. There was a small but significant increase in the level of TGF-β in the lung tissue of TGF-α −/− mice compared with WT mice.…”

Section: Cytokine Responses To Radiationmentioning

confidence: 99%

Cytokines and radiation-induced pulmonary injuries

Lierová

Jeličová

Němcová

et al. 2018

Journal of Radiation Research

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Radiation therapy is one of the most common treatment strategies for thorax malignancies. One of the considerable limitations of this therapy is its toxicity to normal tissue. The lung is the major dose-limiting organ for radiotherapy. That is because ionizing radiation produces reactive oxygen species that induce lesions, and not only is tumor tissue damaged, but overwhelming inflammatory lung damage can occur in the alveolar epithelium and capillary endothelium. This damage may result in radiation-induced pneumonitis and/or fibrosis. While describing the lung response to irradiation generally, the main focus of this review is on cytokines and their roles and functions within the individual stages. We discuss the relationship between radiation and cytokines and their direct and indirect effects on the formation and development of radiation injuries. Although this topic has been intensively studied and discussed for years, we still do not completely understand the roles of cytokines. Experimental data on cytokine involvement are fragmented across a large number of experimental studies; hence, the need for this review of the current knowledge. Cytokines are considered not only as molecular factors involved in the signaling network in pathological processes, but also for their diagnostic potential. A concentrated effort has been made to identify the significant immune system proteins showing positive correlation between serum levels and tissue damages. Elucidating the correlations between the extent and nature of radiation-induced pulmonary injuries and the levels of one or more key cytokines that initiate and control those damages may improve the efficacy of radiotherapy in cancer treatment and ultimately the well-being of patients.

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“…Radix Ginseng is a main component of these 5 CHE. A high pretreatment dose of ginseng extractions resulted in a marked attenuation of the severity of inflammatory changes in lung tissue in a mouse model of RILI and led to significant reductions in TNF- α and TGF- β 1 cytokines [51]. In vivo, ginseng extractions and SFI led to significant reductions in TNF- α and TGF- β 1 cytokines.…”

Section: Discussionmentioning

confidence: 99%

Chinese Herbal Extractions for Relieving Radiation Induced Lung Injury: A Systematic Review and Meta‐Analysis

Deng

Cheng

2017

Evidence-Based Complementary and Alternative Medicine

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Background. Radiation induced lung injury (RILI) is one of the most common and severe side effects of thoracic radiotherapy. In this meta-analysis, the effects of Chinese herbal extractions (CHE) for preventing and treating RILI are evaluated. Methods. Randomized Controlled Trials (RCTs) from five databases were identified. Studies were evaluated and the relevant data were extracted by two authors independently. Differences were resolved by a third party. Meta-analysis was conducted using RevMan 5.0. Results. In total, 2734 participants receiving thoracic radiotherapy were included in 28 RCTs, and 16 CHE were evaluated. Meta-analysis showed that CHE intervention significantly reduced the incidence of acute radiation pneumonitis (RP) and radiation induced pulmonary fibrosis (RIPF). In CHE group, total effective rate and remission rate of RILI patients were significantly higher. Patient's quality of life (Qol) and clinical symptoms and signs were improved significantly. Inflammatory cytokines decreased, and thymus dependent lymphocytes subgroups were improved. Conclusion. CHE intervention may have clinical effectiveness for relieving RILI and related symptoms and signs and lead to improvement of Qol. However, more double-blind, multicenter, large-scale RCTs are needed to support this theory. Trial Registration. PROSPERO International prospective register of systematic reviews has registration number CRD42016043538.

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Modulation of Radiation-Induced Alterations in Oxidative Stress and Cytokine Expression in Lung Tissue byPanax GinsengExtract

Cited by 19 publications

References 33 publications

Protective Role of Nuclear Factor-Erythroid 2-Related Factor 2 Against Radiation-Induced Lung Injury and Inflammation

Protective Role of Nuclear Factor-Erythroid 2-Related Factor 2 Against Radiation-Induced Lung Injury and Inflammation

Cytokines and radiation-induced pulmonary injuries

Chinese Herbal Extractions for Relieving Radiation Induced Lung Injury: A Systematic Review and Meta‐Analysis

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