Modulation of serotonin dynamics in the dorsal raphe nucleus via high frequency medial prefrontal cortex stimulation

Srejic, Luka R.; Wood, Kevin M.; Zeqja, Anisa; Hashemi, Parastoo; Hutchison, William D.

doi:10.1016/j.nbd.2016.06.009

Cited by 15 publications

(7 citation statements)

References 87 publications

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“…It is very important to address the chemical functionality associated with such biophysical changes. We have performed pilot studies in these and other brain areas (Srejic et al ; Abdalla et al ; West et al ), here we present a formal characterization of the voltammetry stimulation and measurement circuits for serotonin in the CA2 region of the hippocampus and the mPFC, compared with the SNr.…”

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confidence: 99%

Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology

Abdalla

West

Jin

et al. 2019

Journal of Neurochemistry

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It is important to monitor serotonin neurochemistry in the context of brain disorders. Specifically, a better understanding of biophysical alterations and associated biochemical functionality within subregions of the brain will enable better of understanding of diseases such as depression. Fast voltammetric tools at carbon fiber microelectrodes provide an opportunity to make direct evoked and ambient serotonin measurements in vivo in mice. In this study, we characterize novel stimulation and measurement circuitries for serotonin analyses in brain regions relevant to psychiatric disease. Evoked and ambient serotonin in these brain areas, the CA2 region of the hippocampus and the medial prefrontal cortex, are compared to ambient and evoked serotonin in the substantia nigra pars reticulata, an area well established previously for serotonin measurements with fast voltammetry. Stimulation of a common axonal location evoked serotonin in all three brain regions. Differences are observed in the serotonin release and reuptake profiles between these three brain areas which we hypothesize to arise from tissue physiology heterogeneity around the carbon fiber microelectrodes. We validate this hypothesis mathematically and via confocal imaging. We thereby show that fast voltammetric methods can provide accurate information about local physiology and highlight implications for chemical mapping. Cover Image for this issue: doi: .

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mentioning

confidence: 99%

Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology

Abdalla

West

Jin

et al. 2019

Journal of Neurochemistry

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“…Srejic et al inhibited ChR2-5-HT neurons in the DRN with blue light stimulation. Serotonin clearance was significantly faster after 5 min high-frequency stimulation, indicating less release or more effective 5-HT reuptake ( 100 ). Another novel pathway that originates from 5-HT in the DRN to somatostatin (SOM)-expressing and non-SOM interneurons in the central nucleus of the amygdala (CeA) in comorbid depressive symptoms (CDS) is identified.…”

Section: Optogenetic Findings In Dysfunctional Neural Circuitsmentioning

confidence: 99%

Advances in optogenetic studies of depressive-like behaviors and underlying neural circuit mechanisms

Shi

Du²,

Xia³

et al. 2022

Front. Psychiatry

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BackgroundsThe neural circuit mechanisms underlying depression remain unclear. Recently optogenetics has gradually gained recognition as a novel technique to regulate the activity of neurons with light stimulation. Scientists are now transferring their focus to the function of brain regions and neural circuits in the pathogenic progress of depression. Deciphering the circuitry mechanism of depressive-like behaviors may help us better understand the symptomatology of depression. However, few studies have summarized current progress on optogenetic researches into the neural circuit mechanisms of depressive-like behaviors.AimsThis review aimed to introduce fundamental characteristics and methodologies of optogenetics, as well as how this technique achieves specific neuronal control with spatial and temporal accuracy. We mainly summarized recent progress in neural circuit discoveries in depressive-like behaviors using optogenetics and exhibited the potential of optogenetics as a tool to investigate the mechanism and possible optimization underlying antidepressant treatment such as ketamine and deep brain stimulation.MethodsA systematic review of the literature published in English mainly from 2010 to the present in databases was performed. The selected literature is then categorized and summarized according to their neural circuits and depressive-like behaviors.ConclusionsMany important discoveries have been made utilizing optogenetics. These findings support optogenetics as a powerful and potential tool for studying depression. And our comprehension to the etiology of depression and other psychiatric disorders will also be more thorough with this rapidly developing technique in the near future.

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“…In vivo detection of neurotransmitters other than dopamine can be challenging primarily because of structural resemblances and low concentrations of similar analytes. Serotonin has been analyzed using a serotonin specific waveform (1000 V s –1 scanning from 0.2 V to 1 V to −0.1 V to 0.2 V) on CFMs modified with NA for both stimulated release of serotonin via FSCV as well as basal measurements with fast-scan controlled adsorption voltammetry (FSCAV). − For the latter study, Abdalla et al employed NA-coated CFMs to measure ambient serotonin in vivo in the hippocampus of mice . In Figure FSCAV color plots (panel A) are presented for in vivo and in vitro serotonin.…”

Section: Biomedical Measurementsmentioning

confidence: 99%

Recent Developments in Carbon Sensors for At-Source Electroanalysis

et al. 2018

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Modulation of serotonin dynamics in the dorsal raphe nucleus via high frequency medial prefrontal cortex stimulation

Cited by 15 publications

References 87 publications

Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology

Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology

Advances in optogenetic studies of depressive-like behaviors and underlying neural circuit mechanisms

Recent Developments in Carbon Sensors for At-Source Electroanalysis

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