2020
DOI: 10.21203/rs.3.rs-27003/v1
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Modulation of steroidogenesis by Actaea racemosa and vitamin C combination, in Letrozole induced polycystic ovarian syndrome rat model: Promising activity without the risk of hepatic adverse effect

Abstract: Background Complementary remedies such as the Chinese herb ‘Sheng Ma’ (Black cohosh; Actaea racemose ‘AR’) are being sought to surmount the shortcomings of conventional hormonal and surgical therapies developed in the treatment of polycystic ovary syndrome (PCOS). However, the AR hepatotoxicity urges a cautionary warning to be labelled on its products as recommended by the United States Pharmacopeia where 4 out of 7 hepatotoxic cases in Sweden were possibly associated with black cohosh products.Methods We inve… Show more

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Cited by 9 publications
(2 citation statements)
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“…Foi investigado os efeitos, segurança e alvos do extrato de A. racemosa (7,14 mg/kg) associado ou não a vitamina C em ratas induzidas a SOP por hiperandrogenismo e tratadas por 28 dias (AZOUZ et al, 2021). Efeitos benéficos foram exercidos pela A. racemosa no status antioxidante, perfil hormonal, perfil lipídico, nível de glicose, funções hepáticas e a expressão de Ki-67 (um marcador de proliferação celular) nas células da granulosa, células da teca e células estromais.…”
Section: Ativação E Atresia Folicularunclassified
“…Foi investigado os efeitos, segurança e alvos do extrato de A. racemosa (7,14 mg/kg) associado ou não a vitamina C em ratas induzidas a SOP por hiperandrogenismo e tratadas por 28 dias (AZOUZ et al, 2021). Efeitos benéficos foram exercidos pela A. racemosa no status antioxidante, perfil hormonal, perfil lipídico, nível de glicose, funções hepáticas e a expressão de Ki-67 (um marcador de proliferação celular) nas células da granulosa, células da teca e células estromais.…”
Section: Ativação E Atresia Folicularunclassified
“…In PCOS, ultrasound is used to detect the presence of multiple small cysts in the ovaries. However, the interpretation of ultrasound images for the diagnosis of PCOS is subjective and relies on the expertise of the interpreting physician [8][9][10]. Therefore, there is a need for more objective and accurate methods for the diagnosis of PCOS using ultrasound imaging.Ultrasound imaging is widely used in the diagnosis of PCOS.…”
Section: Introductionmentioning
confidence: 99%