1994
DOI: 10.1172/jci117044
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Modulation of the effector function of human monocytes for Mycobacterium avium by human immunodeficiency virus-1 envelope glycoprotein gp120.

Abstract: Disseminated Mycobacterium avium infection in AIDS is associated with high tissue burdens (109-10i1 mycobacteria/g tissue) of organism. The basis for the extraordinary susceptibility of AIDS to M. avium infection is unclear. HIV or its constituents may alter mononuclear phagocyte functions resulting in enhanced intracellular M. avium growth. The effects of an envelope glycoprotein (gpl20), a transmembrane protein (pl21), and core proteins of HIV-1 on M. avium infection of human monocytes were examined. Precult… Show more

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Cited by 38 publications
(19 citation statements)
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“…Studies with other microorganisms have demonstrated that the envelope glycoprotein gp120 can modulate M phagocytosis and antimicrobial activity through binding to M CD4 receptors (28,29). Therefore, we sought to determine if gp120 might impair M interaction with Hc.…”
Section: Kinetics Of Hiv-1 Replication In Human Mmentioning
confidence: 99%
“…Studies with other microorganisms have demonstrated that the envelope glycoprotein gp120 can modulate M phagocytosis and antimicrobial activity through binding to M CD4 receptors (28,29). Therefore, we sought to determine if gp120 might impair M interaction with Hc.…”
Section: Kinetics Of Hiv-1 Replication In Human Mmentioning
confidence: 99%
“…Infected macrophages serve as reservoirs for viral persistence, and aberrant functions of both infected and uninfected macrophages have been implicated in pathogenesis (5)(6)(7)(8). Macrophages express CD4, CCR5, and CXCR4 (9,10), but the ability of macrophage chemokine receptors to support HIV-1 infection is both cell and strain-specific.…”
mentioning
confidence: 99%
“…This, in fact, has been shown by the work of Shiratsuchi and colleagues (64). These authors have demonstrated that HIV-1 envelop protein gp120 and core proteins p24 and gag5 when used to treat macrophages for 2 days prior to M. avium infection inhibited phagocytosis and enhanced intracellular growth of the bacteria.…”
Section: Interaction Between M Avium and Hiv-1mentioning
confidence: 70%
“…These authors have demonstrated that HIV-1 envelop protein gp120 and core proteins p24 and gag5 when used to treat macrophages for 2 days prior to M. avium infection inhibited phagocytosis and enhanced intracellular growth of the bacteria. Production of cytokines such as IL-1, TNF-α and IL-6 were increased in macrophages infected with M. avium and exposed to gp120 in comparison with both macrophages exposed to gp120 and macrophages infected with M. avium (64). Thus, it seems clear that HIV-1 infection probably favors M. avium growth within macrophages and certainly has a negative impact on the outcome of the disseminated disease.…”
Section: Interaction Between M Avium and Hiv-1mentioning
confidence: 94%