Modulation of the endogenous leukotriene production by fish oil and vitamin E

Denzlinger, Claudio; Kless, T; Sagebiel-Kohler, Sabine; Lemmen, Christa; Jacob, K.; Wilmanns, W.; Adam, O.

doi:10.1016/0929-7855(94)00032-8

Cited by 16 publications

(3 citation statements)

References 37 publications

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“…More recently, vitamin E has been shown to have additional properties that may be relevant to protection against CVD. These include inhibition of endothelial cell adhesion, 18–20 inhibition of platelet aggregation, 21,22 inhibition of vascular smooth muscle proliferation, 23 and reduction of leukotriene synthesis by neutrophils 24 . Analysis of this data in isolation gives credence to a potential role for Vitamin E in atherosclerosis.…”

Section: The Rationalementioning

confidence: 94%

Treatment of Atherosclerosis in the New Millennium: Is There a Role for Vitamin E?

Meagher

2003

Preventive Cardiology

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Oxidative stress appears to be of fundamental relevance to diseases as diverse as atherosclerosis, cancer, and Alzheimer's disease. Observational data in humans have suggested that antioxidant vitamin intake is associated with reduced cardiovascular disease. Animal studies are largely consistent with the concept that dietary supplementation with antioxidant vitamins reduces the progression of atherosclerosis. However, recent prospective, controlled clinical trials of vitamin E, including the Cardiovascular Disease, Hypertension and Hyperlipidemia, Adult-Onset Diabetes, Obesity, and Stroke (CHAOS) study, the Heart Outcomes Prevention Evaluation (HOPE) trial, Gruppo Italiano per lo Studio della Sopravvivvenza nell'Infarto Miocardico (GISSI)-Prevenzione trial, the Secondary Prevention with Antioxidants of Cardiovascular Disease in End Stage Renal Disease (SPACE) trial, and the Heart Protection Study (HPS) present a confused picture. The various possibilities that have been advanced to explain this discrepancy are discussed in this review. A striking feature of these and other trials of antioxidants is the absence of a biochemical basis for patient inclusion or, indeed, dose selection. Patients with high levels of oxidant stress or depletion of natural antioxidant defense systems may be the most likely to benefit from antioxidant therapy. If this is the case, then reliable, quantitative indices of in vivo oxidant stress such as urinary isoprostane levels should be considered as an inclusion criterion for patient selection. Future trials of antioxidant therapy in cardiovascular disease should then be targeted toward such patients with high levels of oxidant stress or patients with depletion of natural antioxidant defense systems. Furthermore, the dose of antioxidant should be chosen based on a surrogate readout that is a reliable, reproducible, and easily obtainable in vivo measure of oxidant stress. In the interim, although the safety of vitamin E up to doses of 800 IU/day has been determined, the conflicting nature of the results published to date encourages us to avoid making premature recommendations with respect to vitamin E supplementation in the prevention and treatment of cardiovascular disease.

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Section: The Rationalementioning

confidence: 94%

Treatment of Atherosclerosis in the New Millennium: Is There a Role for Vitamin E?

Meagher

2003

Preventive Cardiology

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“…Omega-3-Fettsäuren können durch ihre Wirkung auf das Eicosanoidsystem die Folgereaktion der pro-inflam-matorischen Mediatoren vermindern (15) und wirken den pro-inflammatorischen Effekten der Mediatoren entgegen (44).…”

Section: Pathogenese Der Arterioskleroseunclassified

Omega-3-Fettsäuren und Arteriosklerose

2003

Ernährung & Medizin

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“…Für die mRNA des LTA 4 wurde eine besonders kurze Halbwertszeit ermittelt, die für die schnelle Expression und Inhibition dieses Stoffwechselweges verantwortlich ist [7]. Tatsächlich kann durch eine Supplementierung mit Vitamin E eine bevorzuge Verminderung der LT-Bildung, gemessen als LTE 4 + N-azetyl-LTE 4 , bei Gesunden nachweisen [8]. Im Tierversuch konnte andererseits eine Hemmung der LTB 4 -induzierten Arthritis durch Lipoxin A 4 gezeigt werden.…”

Section: Rolle Der Eikosanoide Und Zytokine Bei Der Entzündungunclassified

Ernährung und Immunsystem: Rheuma

Adam¹

2002

Akt Ernähr Med

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Modulation of the endogenous leukotriene production by fish oil and vitamin E

Cited by 16 publications

References 37 publications

Treatment of Atherosclerosis in the New Millennium: Is There a Role for Vitamin E?

Treatment of Atherosclerosis in the New Millennium: Is There a Role for Vitamin E?

Omega-3-Fettsäuren und Arteriosklerose

Ernährung und Immunsystem: Rheuma

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