Modulation of the IGF system and proliferation in human endometrial stromal cells by metformin: a dose-dependent effect

Jung, Marie-Luise; Renke, Tobias; Nowak, Oliver; Jauckus, Julia; Zorn, Markus; Capp, Edison; Strowitzki, T.; Germeyer, Ariane

doi:10.1007/s00404-015-3650-0

Cited by 8 publications

(2 citation statements)

References 36 publications

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“…Since, however, stromal maturation was not affected, it is not known if this delay in only one aspect of endometrial maturation can have an impact on embryo implantation. In vitro experiments have demonstrated that metformin diminishes decidualization and stromal cell proliferation in human endometrium in a dose-dependent manner [38]. However, extrapolating the in-vitro data into clinical reality is a challenge but requires confirmation via clinical research.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome

Dragamestianos

Messini

Antonakis

et al. 2018

Gynecol Obstet Invest

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Objectives: To investigate the effect of metformin on endometrial receptivity in women with polycystic ovary syndrome (PCOS). Methods: Twenty volunteer women with polycystic ovaries and oligomenorrhea were prospectively investigated. All women were treated with exogenous estradiol and progesterone to simulate a normal menstrual cycle (28-day duration) after GnRH-induced pituitary desensitization. Ten of the women received no other medication (group A, control), while the remaining 10 received metformin (group B, metformin). Endometrial biopsy was performed in all women on day 21 of the 2 simulated cycles. Results: The expression of corticotropin – releasing hormone and urocortin in the endometrium was investigated. There was no significant difference between the 2 groups. A 3-day delay in the secretory maturation of the glandular epithelium relatively to the stroma was observed in 7 out of 10 women of group B (70%) as compared to only 1 out of 10 women of group A (10%, p = 0.02). Conclusions: It is shown for the first time that metformin administration to women with PCOS did not affect the expression of endometrial receptivity markers but delayed histological glandular maturation. It is suggested that metformin may have an impact on the function of the endometrium in PCOS.

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Section: Discussionmentioning

confidence: 99%

The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome

Dragamestianos

Messini

Antonakis

et al. 2018

Gynecol Obstet Invest

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show abstract

“…Это предположение на-ходит свое подтверждение в исследовании in vitro на клеточной линии стромальных клеток эндометрия, в котором были показаны дозоза-висимые эффекты метформина. Применение препарата в концентрации 10 -4 М вызывало децидуализацию клеток, увеличение концен-трации до 10 -3 М сопровождалось подавлением клеточной пролиферации [15].…”

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Prospects of metformin in the treatment of endometriosis

2017

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According to recent year studies, the classical biguanide metformin has antiproliferative, proapoptotic and anti-inflammatory effects in addition to the main hypoglycemic effect. There are clinical and experimental studies these effects in the therapy of oncological and benign hyperplastic diseases. There is no data about the clinical efficacy of metformin in the therapy of endometriosis in the domestic literature, and there were a few studies in foreign sources. There was a decrease in the severity of the pain syndrome and an increase of pregnancy rate in two clinical studies with small samples. However, future studies are needed to investigate the mechanisms of the target drug effect and to develop effective regimens for the treatment of endometriosis.

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Effects of a hyperandrogenaemic state on the proliferation and decidualization potential in human endometrial stromal cells

Freis

Renke

Kämmerer

et al. 2017

Arch Gynecol Obstet

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Modulation of the IGF system and proliferation in human endometrial stromal cells by metformin: a dose-dependent effect

Cited by 8 publications

References 36 publications

The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome

The Effect of Metformin on the Endometrium of Women with Polycystic Ovary Syndrome

Prospects of metformin in the treatment of endometriosis

Effects of a hyperandrogenaemic state on the proliferation and decidualization potential in human endometrial stromal cells

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