Modulation of the platelet thromboxane A2 and aortic prostacyclin synthesis by dietary selenium and vitamin E

Meydani, Mohsen

doi:10.1007/bf02783995

Cited by 37 publications

(15 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…30 In the present study, interestingly, liver and heart arginase activities in the combination group recovered to the level of control group after 48 h of prednisolone administration (Tables 2 and 4). This observation may suggest that vitamin E and Se in combination may prevent changes in arginase activity caused by prednisolone in different tissues.…”

Section: Discussionsupporting

confidence: 60%

Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid

Erişir

Beytut

Özan

et al. 2003

Cell Biochemistry & Function

View full text Add to dashboard Cite

The effects of dietary intake of vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of prednisolone were investigated. Rats were divided into five groups. Groups 3, 4, and 5 received a daily supplement in their drinking water of vitamin E, Se, and a combination of vitamin E and Se, respectively, for 30 days. For 3 days subsequently, the control group (group 1) was given a placebo, and the remaining four groups were injected intramuscularly with prednisolone. The tissue samples were collected from each group at 4, 8, 12, 24, and 48 h after the last administration of prednisolone. In the group treated with prednisolone alone, arginase activity in the liver was found to have increased at all the time periods, whereas it had decreased significantly in the heart at 48 h. Arginase activity in the kidneys was not affected by prednisolone. Compared to the control and prednisolone groups, arginase activity in the kidneys and heart of the vitamin E- and Se-supplemented groups was found to be significantly increased at all time periods, however, no difference was seen in the combination group. Arginase activity in the liver of the vitamin E-supplemented group was found to have decreased at all time periods, however, in the Se group compared to the prednisolone group it had reduced at 24 and 48 h only. In the combination group compared to the prednisolone group, liver arginase activity increased constantly up to 12 h returning to normal values at 48 h. Vitamin E and Se in combination may prevent the changes in arginase activity in various tissues caused by prednisolone.

show abstract

Section: Discussionsupporting

confidence: 60%

Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid

Erişir

Beytut

Özan

et al. 2003

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

“…Sey and Schutz 25 reported that the metabolism of two essential fatty acids, linoleic and arachidonic acids are aected by vitamin E and Se. In addition, Meydani 9 indicated that both vitamin E and GSH±Px may modulate arachidonic acid metabolism.…”

Section: Discussionmentioning

confidence: 98%

“…Meydani 9 reported that vitamin E and Se have many synergistic functions in cells. One of the most important functions is antioxidant action, which operates both intracellularly and intercellularly.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin E de®ciency reduced plasma vitamin E concentrations to 5±7 per cent of that of control-fed rats, and in vitamin E-supplemented animals, GSH±Px was increased up to 17 per cent as compared to vitamin E-de®cient rats. 9 Numerous studies have been done on the eects of selenium and vitamin E with smaller species, such as rats and rabbits, but studies with ruminants are of great interest since rumen microorganisms convert unsaturated fatty acids to saturated fatty acids 10,11 and vitamin E prevents oxidation of various compounds including polyunsaturated fatty acids, 12 such studies are few however. In vitro and in vivo studies in sheep have shown that selenium and vitamin E supplementation markedly increases the number and activity of rumen microorganisms.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Influence of dietary selenium and vitamin E on the levels of fatty acids in brain and liver tissues of lambs

Çelik

Yılmaz

Aşan

et al. 1999

Cell Biochem. Funct.

View full text Add to dashboard Cite

In this study, the effects of dietary vitamin E, selenium, and their combination on the levels of fatty acid composition of the brain and liver tissues were examined. In brain tissue, the amounts of most fatty acids increased in vitamin E, combination and selenium groups compared with control group values. While the proportions of myristic, pentadecanoic, palmitic, linoleic, and total saturated fatty acids were decreased in vitamin E, Se and combination groups, eicosapentaenoic, total unsaturated and MUFA were increased in the same groups. In addition, the proportions arachidonic, eicosapentaenoic, total unsaturated, omega 6 and MUFA in the combination group were higher than in the control group. In liver tissue, the amounts of myristic, pentadecanoic, palmitic, eicosedienoic, eicosapentaenoic, docosahexaenoic, omega 3 and PUFA were higher in the combination group than in the control group. Also the proportions of eicosapentaenoic, docosahexaenoic acids in supplemented groups were higher than those in the control group. We conclude that dietary vitamin E and selenium have an influence on the levels of fatty acids in the brain and liver.

show abstract

“…Antioxidant defense is achieved by additive or synergistic action of enzymes and antiox-idant nutrients (11,12). Selenium and vitamin E in particular appear to have overlapping and partly compensative functions (13)(14)(15)(16)(17). Therefore, it is conceivable that the relation between selenium status and risk of coronary heart disease is influenced by the status of other antioxidants, as has been observed in an animal experiment (18).…”

mentioning

confidence: 98%

Association Between Toenail Selenium and Risk of Acute Myocardial Infarction in European Men: The EURAMIC Study

Kardinaal

Kok

Kohlmeier

et al. 1997

American Journal of Epidemiology

View full text Add to dashboard Cite

The association between selenium status and risk of acute myocardial infarction was examined in a multicenter case-control study in 10 centers from Europe and Israel in 1991-1992. Selenium in toenails was assessed for 683 nonfatal male cases with first acute myocardial infarction and 729 controls less than 70 years of age. Median toenail selenium content was 0.553 /xg/g for cases and 0.590 jxg/g for controls. After adjustment for age, center, and smoking, the odds ratio for myocardial infarction in the highest quintile of selenium as compared with the lowest was 0.63 (95 percent confidence interval 0.37-1.07, p for trend = 0.08). The observed inverse trend was somewhat stronger when the authors adjusted for vitamin E status (p = 0.05). Analysis stratified for smoking habits showed an inverse association in former smokers (odds ratio for the 75th-25th percentile contrast = 0.63 (95 percent confidence interval 0.43-0.94)), but not in current smokers (odds ratio = 0.97 ( 0.71-1.32)) or in those who had never smoked (odds ratio = 1.55 (0.87-2.76)). Analysis stratified by center showed a significant inverse association between selenium levels and risk of myocardial infarction for Germany (Berlin) only (75th to 25th percentile odds ratio = 0.62 (95 percent confidence interval 0.42-0.91)), which was the center with the lowest selenium levels. It appears that the increased risk of acute myocardial infarction at low levels of selenium intake is largely explained by cigarette smoking; selenium status does not appear to be an important determinant of risk of myocardial infarction at the levels observed in a large part of Europe. Am J Epidemiol 1997;145:373-9. antioxidants; case-control studies; myocardial infarction; selenium Evidence is accumulating that oxidation of low density lipoprotein particles and cytotoxic effects of lipid peroxides enhance the formation of foam cells and atherosclerotic lesions (1, 2). Selenium is part of the enzyme glutathione peroxidase, which plays an important role in the antioxidant defense of the body against the deleterious actions of free radicals and lipid per-

show abstract

Modulation of the platelet thromboxane A2 and aortic prostacyclin synthesis by dietary selenium and vitamin E

Cited by 37 publications

References 43 publications

Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid

Effects of dietary vitamin E and selenium on arginase activity in the liver, kidneys, and heart of rats treated with high doses of glucocorticoid

Influence of dietary selenium and vitamin E on the levels of fatty acids in brain and liver tissues of lambs

Association Between Toenail Selenium and Risk of Acute Myocardial Infarction in European Men: The EURAMIC Study

Contact Info

Product

Resources

About