Modulation of the Ras/MAPK Signalling Pathway by the Redox Function of Selenoproteins in Drosophila melanogaster

Morey, Marta; Serras, Florenci; Baguñà, Jaume; Hafen, Ernst; Corominas, Montserrat

doi:10.1006/dbio.2001.0389

Cited by 50 publications

(30 citation statements)

References 55 publications

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“…Previous studies have pointed to the important roles ROS can play in developmental processes in animals, for example in the Drosophila eye (Morey et al, 2001), and in mammalian glial and neuronal cells (Smith et al, 2000;Suzukawa et al, 2000) and also in plants in the formation of cotton fibres (Potikha et al, 1999). Our observations extend the range of organisms that utilise such redox-mediated signals to the protozoa.…”

Section: Discussionsupporting

confidence: 64%

Superoxide signalling required for multicellular development ofDictyostelium

Bloomfield

Pears

2003

Journal of Cell Science

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Reactive oxygen species are known to have a signalling role in many organisms. In bacteria and yeast various response systems have evolved to combat oxidative stress which are triggered by reactive oxygen species. Mammals and plants are known to actively generate reactive oxygen species such as superoxide during signalling responses to a variety of extracellular factors. We report here the generation of superoxide as a signalling molecule in early development of Dictyostelium discoideum. Dictyostelium grows as single amoebae but, on starvation, the single cells aggregate to form a multicellular organism. Superoxide is generated in response to a secreted factor during the transition to the multicellular phase of development. Scavenging superoxide, either pharmacologically or by overexpressing the enzyme superoxide dismutase, inhibits the formation of the aggregate. This report of the use of superoxide as a signalling molecule in a lower eukaryote as it switches to a multicellular phase suggests that this signalling mechanism arose early in the evolution of multicellular organisms, perhaps as a necessary consequence of the need to diversify the number and type of signalling pathways available to facilitate intercellular communication.

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Section: Discussionsupporting

confidence: 64%

Superoxide signalling required for multicellular development ofDictyostelium

Bloomfield

Pears

2003

Journal of Cell Science

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“…A second interesting example is SelD, which encodes a selenophosphate synthetase. Loss-of-function mutations in SelD result in multiple hair cells and abnormal polarity (Alsina et al 1998;Morey et al 2001). We found SelD expression fell 3.1-fold between 24 and 40 hr, but once again this was not significant (P ¼ 0.11).…”

Section: Resultsmentioning

confidence: 58%

Gene Expression During Drosophila Wing Morphogenesis and Differentiation

Ren

Zhu

Lee³

et al. 2005

Genetics

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The simple cellular composition and array of distally pointing hairs has made the Drosophila wing a favored system for studying planar polarity and the coordination of cellular and tissue level morphogenesis. We carried out a gene expression screen to identify candidate genes that functioned in wing and wing hair morphogenesis. Pupal wing RNA was isolated from tissue prior to, during, and after hair growth and used to probe Affymetrix Drosophila gene chips. We identified 435 genes whose expression changed at least fivefold during this period and 1335 whose expression changed at least twofold. As a functional validation we chose 10 genes where genetic reagents existed but where there was little or no evidence for a wing phenotype. New phenotypes were found for 9 of these genes, providing functional validation for the collection of identified genes. Among the phenotypes seen were a delay in hair initiation, defects in hair maturation, defects in cuticle formation and pigmentation, and abnormal wing hair polarity. The collection of identified genes should be a valuable data set for future studies on hair and bristle morphogenesis, cuticle synthesis, and planar polarity.

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“…However, little information is available about the molecular features and immune response against pathogen infection in the commercially cultured clam Venerupis philippinarum. The main objectives of this study are: (1) to clone the full-length cDNA of icCu/Zn-SOD from V. philippinarum (VpSOD), (2) to investigate the expression profile of VpSOD after being infected by Vibrio pathogen.…”

Section: Introductionmentioning

confidence: 99%