Modulation of tumor microenvironment using a TLR-7/8 agonist-loaded nanoparticle system that exerts low-temperature hyperthermia and immunotherapy for in situ cancer vaccination

Chen, Po Ming; Pan, Wen; Wu, Cheng; Yeh, Ching Yen; Korupalli, Chiranjeevi; Luo, Po Kai; Chou, Chun Ju; Chia, Wei-Tso; Sung, Hsing Wen

doi:10.1016/j.biomaterials.2019.119629

Cited by 102 publications

(62 citation statements)

References 56 publications

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“…At day 14 post-treatment, the representative photographs of excised tumors demonstrated a prominent tumor inhibition effect for C6TI/Apo-Tat NPs upon NIR laser irradiation (Figure 3 c and Figure S24). Nevertheless, this therapeutic efficacy by low-temperature PTT is higher than the reported results, [16] owing to the fact that Apo can efficiently prevent the cytoprotective pathway of the dominant HSP factor, HSP70. [12] Figure 2. a) Normalized UV/Vis/NIR absorption spectra of C6TI in THF and C6TI NPs in PBS.…”

Section: Angewandte Chemiementioning

confidence: 66%

A Photoinduced Nonadiabatic Decay‐Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy

Zhang

Yang

et al. 2020

Angewandte Chemie

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It remains highly challenging to identify small molecule‐based photothermal agents with a high photothermal conversion efficiency (PTCE). Herein, we adopt a double bond‐based molecular motor concept to develop a new class of small photothermal agents to break the current design bottleneck. As the double‐bond is twisted by strong twisted intramolecular charge transfer (TICT) upon irradiation, the excited agents can deactivate non‐radiatively through the conical intersection (CI) of internal conversion, which is called photoinduced nonadiabatic decay. Such agents possess a high PTCE of 90.0 %, facilitating low‐temperature photothermal therapy in the presence of a heat shock protein 70 inhibitor. In addition, the behavior and mechanism of NIR laser‐triggered molecular motions for generating heat through the CI pathway have been further understood through theoretical and experimental evidence, providing a design principle for highly efficient photothermal and photoacoustic agents.

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Section: Angewandte Chemiementioning

confidence: 66%

A Photoinduced Nonadiabatic Decay‐Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy

Zhang

Yang

et al. 2020

Angewandte Chemie

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“…[48] These immunoadjuvants can activate TLRrelated signaling pathways,s ubsequently promoting the maturation of DCs,s ecretion of proinflammatory cytokines and chemokines,a nd activation of immune responses.S ung and Chiasg roups reported the use of aR 848-loaded NP (R848@NP) for combinational mild PTT and immunotherapy. [49] TheR848@NP was formed through self-assembly of an amphiphilic polyaniline-glycol-chitosan (PANI-GCS) copolymer synthesized using an oxidative polymerization method, followed by loading of R848 into the hydrophobic core.Inthe tumors after local injection of R848@NP,the temperature was mildly increased via PA NI-mediated PTT upon NIR laser irradiation at 808 nm, resulting in sectional tumor cell death and TAAg eneration. Thes ynergistic action of PTT-induced TAAs and R848 modulated the immunosuppressive tumor microenvironment and induced as trong antitumor immune response.T hus,R 848@NP-mediated combinational PTT and immunotherapy led to complete regression of subcutaneous CT26 tumors and effective suppression of tumor recurrence and metastasis.…”

Section: Combination Of Ptt With Adjuvant Immunotherapymentioning

confidence: 99%

Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Luo

2021

Angewandte Chemie

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Immunotherapy that harnesses the power of the immune system to eliminate malignant cells has offered an effective approach for cancer treatment. However, limited patient response rates and potential immune‐related adverse events exist as two major issues for cancer immunotherapy. In parallel, a variety of electromagnetic nanomaterials that generate heat and/or reactive oxygen species triggered by electromagnetic energy have been applied for magnetic hyperthermia therapy, sonodynamic therapy, photothermal therapy, photodynamic therapy, and radiotherapy, which have the ability to induce immunogenic cell death. This review summarizes the recent development of electromagnetic nanomedicines in combinational cancer immunotherapy. The mechanisms of electromagnetic nanomedicines in reprogramming the immunosuppressive tumor microenvironment and sensitizing tumors for cancer immunotherapy are highlighted. Furthermore, potential challenges and perspectives of electromagnetic nanomedicines for combinational cancer immunotherapy are discussed.

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“…Apart from this, PANI was also combined with immunotherapeutic drugs [ 61 ] through hydrophobic interactions to achieve PTT mediated immunotherapy. Overall, the results from these studies reveal that the therapeutic outcome can be enhanced using combinational therapy and necessitating further development of such strategies using PANI.…”

Section: Pani-based Biomaterials For Tumor Ablationmentioning

confidence: 99%

Recent Advances of Polyaniline-Based Biomaterials for Phototherapeutic Treatments of Tumors and Bacterial Infections

et al. 2020

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Conventional treatments fail to completely eradicate tumor or bacterial infections due to their inherent shortcomings. In recent years, photothermal therapy (PTT) has emerged as an attractive treatment modality that relies on the absorption of photothermal agents (PTAs) at a specific wavelength, thereby transforming the excitation light energy into heat. The advantages of PTT are its high efficacy, specificity, and minimal damage to normal tissues. To this end, various inorganic nanomaterials such as gold nanostructures, carbon nanostructures, and transition metal dichalcogenides have been extensively explored for PTT applications. Subsequently, the focus has shifted to the development of polymeric PTAs, owing to their unique properties such as biodegradability, biocompatibility, non-immunogenicity, and low toxicity when compared to inorganic PTAs. Among various organic PTAs, polyaniline (PANI) is one of the best-known and earliest-reported organic PTAs. Hence, in this review, we cover the recent advances and progress of PANI-based biomaterials for PTT application in tumors and bacterial infections. The future prospects in this exciting area are also addressed.

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Modulation of tumor microenvironment using a TLR-7/8 agonist-loaded nanoparticle system that exerts low-temperature hyperthermia and immunotherapy for in situ cancer vaccination

Cited by 102 publications

References 56 publications

A Photoinduced Nonadiabatic Decay‐Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy

A Photoinduced Nonadiabatic Decay‐Guided Molecular Motor Triggers Effective Photothermal Conversion for Cancer Therapy

Electromagnetic Nanomedicines for Combinational Cancer Immunotherapy

Recent Advances of Polyaniline-Based Biomaterials for Phototherapeutic Treatments of Tumors and Bacterial Infections

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