Modulation the Neuro-toxicity Induced by Aluminum Chloride in Rats Using Beetroots and Broccli Extracts

Al-Balawi, Abeer Ali; Ahmed, Yousri Mohamed; Albukhari, Ashwag; AlGhamdi, Shareefa A.; Zeyadi, Mustafa; Maddah, Morog R.; Huwait, Etimad; Ali, Soad Shaker; Kumosani, Taha A.; Moselhy, Said S

doi:10.9734/jpri/2018/v25i330100

Cited by 4 publications

(3 citation statements)

References 39 publications

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“…Noradrenaline was estimated using NA/NE (Noradrenaline/Norepinephrine) ELISA Kit supplied by Fine Test, Wuhan (Al-Balawi et al, 2018). Histopathological study: Autopsy samples were taken from the rats in the four previously mentioned experimental groups.…”

Section: Methodsmentioning

confidence: 99%

Histopathological and Neurotransmitter Changes in Albino Rats’ Brain after Consumption of Energy Drink in Egypt

Hassan,

Ghaleb,

Nabil

et al. 2023

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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Background: Energy drinks are carbonated non-alcoholic beverages, used during exercise and different sports for increasing physical strength and mental alertness. Recently they are widely used by different ages of male and female. Visits to the emergency department due to energy drinks consumption were doubled from 2007 to 2011. Most of Energy drinks have attractive names as to express the speed, power, and strength. Energy drinks have a lot of ingredients and some of them are not approved by the food and drug administration (FDA). Methods: A total of eighty adult albino rats were divided randomly into four groups (20 per each). Control group: not exposed to any treatment and received tap water. Second, third and fourth group received a dose of (3.8ml\100g) of body weight for 3 weeks orally of three different energy drinks brands available in Egyptian markets (Power horse, Red bull, Sting) respectively. Results: Our results concerning energy drinks effects on brain disclosed significant increase of stimulant neurotransmitters of norepinephrine and dopamine with significant decrease of inhibitory neurotransmitter of Gamma-aminobutyric acid in response to high dose of energy drinks, which were consistent with findings of histopathological examination that showed severe degenerative changes and necrosis of neural cells of the brain on the cerebral cortex and hippocampus neurons, indicating toxic effect of energy drinks on neurons of the brain. Conclusion: Energy drinks consumption in high dose had marked hyper stimulating toxic effects on brain stimulatory neurotransmitters and degeneration of neurons in different regions of the brain.

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Section: Methodsmentioning

confidence: 99%

Histopathological and Neurotransmitter Changes in Albino Rats’ Brain after Consumption of Energy Drink in Egypt

Hassan,

Ghaleb,

Nabil

et al. 2023

Ain Shams Journal of Forensic Medicine and Clinical Toxicology

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“…Animals received standard laboratory diet and water adlibitum. Neurodegenerative impairment was induced by aluminum chloride administration of 20 mg/kg b.w daily for one month (Balawi et al, 2018). Fish oil (Omega -3 fatty acids) was given orally by stomach tube as 0.4 g/kg bw (Songur et al, 2004).…”

Section: Methodsmentioning

confidence: 99%

Preparing of Probiotic Tahini as A Novel Functional Food and Investigate its Effect along with Fish Oil against Alzheimer’s Disease in Rats إعداد طحینة متخمرة بالبکتیریا الحیویة کغذاء وظیفی جدید و دراسة تأثیرها على مرض الزهایمر مع المعاملة بزیت السمک فی الفئران

الزمزمي¹

2019

Journal of Food and Dairy Sciences

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Aluminum is a neurotoxic element naturally and abundantly occurs in the environment in drinking water, foodstuffs, Drugs, cosmetics. Evidence indicates that Probiotics can improve cognitive impairment through Gut-Brain Axis communication. Fish oil, sesame, wheat germ and olive oil were previously used in reducing the risk of Alzheimer disease. Objective of thhis study was to produce probiotic nutraceutical product by using Bifidibacterium longum in fermentation of Tahina made from Sesame seeds, wheat germ and olive oil and investigate its effect on rat experimental model of Alzheimer's disease induced by Alcl3. Methods: Product was chemically and sensory evaluated and biological evaluation was carried out as follows: Group 1: Normal control group, administered drinking water only; Group 2: (Neurogenerative) rats was orally administered by aluminum chloride (20 mg/kg b.w) daily for one month; Group 3: Rats given aluminum chloride and treated with Omega 3 fatty acids (FA) for six weeks; Group 4: Rats given aluminum chloride and treated with Omega 3 FA (7.0 g/ kg bw) + sesame Tahini; Group 5: Rats given aluminum chloride and treated with Omega 3 FA + fermented sesame Tahini. Memory and oxidative stress biomarkers were assessed represented as acetylcholin (Ach), (acetylcholinesterase) AchE, brain derived neurotrophic factor (BDNF). Amyloid β, GSH, GSSG, total protein (TPL) and Cholesterol. Results showed that AchE, Amyloid β peptide, GSSG and cholesterol levels were significantly elevated in AlCl3 treated group, however Ach, BDNF, GSH, TPL levels were declined. All previous markers were ameliorated by fish oil treatment. Addition of Tahina with fish oil was more effective than only fish oil treated group, however the most effective treatment was that included the malty therapeutic factors; Fish oil, and Sesame Tahina fermented by B.longum. In conclusion; Tahina composed of Sesame seeds, wheat germ and olive oil and fermented by B.longum might have anti neurodegeneration properties against AlCl3 induced Alzheimer's disease.

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“…G1 (control): normal rats were injected intraperitoneally (IP) with saline (1 ml/kg b wt) three days/week for four weeks. G2 (RBPE): normal rats were injected IP with RBPE at a dose of 50 mg/kg b.wt according to Al-Balawi et al [28], three days/week for four weeks. G3 (IR): rats were whole body irradiated with acute dose of 6 Gy of γ rays.…”

Section: Experimental Designmentioning

confidence: 99%

The Protective Role of Red Beetroot (Beta Vulgaris L.) Peel Extract against Gamma Irradiation Induced Hepatic Apoptosis in Rats

Hamed,

Hammad

2023

Arab Journal of Nuclear Sciences and Applications

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Exposure to gamma radiation causes oxidative stress and generation of reactive oxygen species, which cause hepatocellular apoptosis, so it is necessary to keep safe the living organisms especially humans and animals. Red beetroot (Beta vulgaris L.) is thought to be crucial for enhancing hepatic health. Male Wistar albino rats were designated to evaluate the possible protective role of red beetroot peel extract (RBPE) to alleviate oxidative stress that associated with gamma-ray exposure. Biochemical, histopathology, and immunehistochemical analyses of rat livers exposed to acute radiation dose revealed different apoptotic patterns. According to the findings, RBPE has a DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) scavenging activity of 1.22±0.23 mg TE/g. The total phenolic and flavonoid contents of RBPE were 126.21±0.39 mg GE/g and 67.18±0.78 mg QE/g, respectively. Results showed that pre-administration of RBPE (50 mg/kg body weight for two weeks before and after exposure to 6 Gy gamma irradiation reduce elevations in liver enzymes and apoptotic markers [caspase-3, and B-cell lymphoma-2-associated protein X (Bax) and elevate the expression of the B-cell lymphoma-2 (Bcl-2). These findings were supported by the histological analyses, which demonstrated that RBPE shielded the rats' livers against gamma-irradiation-induced damage. The protective effects are most likely due to the potent antioxidant phenols in RBPE that working together synergistically. It is concluded that RBPE is a promising radioprotector for liver against oxidative stress induced by exposure to gamma ionizing radiation due to its antioxidant and antiapoptotic power.

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Modulation the Neuro-toxicity Induced by Aluminum Chloride in Rats Using Beetroots and Broccli Extracts

Cited by 4 publications

References 39 publications

Histopathological and Neurotransmitter Changes in Albino Rats’ Brain after Consumption of Energy Drink in Egypt

Histopathological and Neurotransmitter Changes in Albino Rats’ Brain after Consumption of Energy Drink in Egypt

The Protective Role of Red Beetroot (Beta Vulgaris L.) Peel Extract against Gamma Irradiation Induced Hepatic Apoptosis in Rats

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