Modulatory effect of two regimens of magnesium sulfate on the systemic inflammatory response in pregnant women with imminent eclampsia

A Mini-Review of Magnesium Sulfate's Anti-Inflammatory, Immune, and Neuroprotective Mechanisms in Subarachnoid Hemorrhage

“…In vitro studies have demonstrated that MS can interfere with the nuclear translocation of NF-κB p65 subunit, thereby limiting its transcriptional activity [9]. This mechanism seems to be critical in curbing the production of pro-inflammatory cytokines such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) [10], which are known to be associated with poor prognosis in SAH patients [11,12]. For instance, a retrospective analysis published in 2022 suggested that serum IL-6 peak was independently associated with long-term mortality in a multivariate model evaluating aneurysmal SAH patients [12].…”