Modulatory mechanism underlying how dietary constituents attenuate orofacial pain

Abstract

Physiological pain protects the body and its systems from damage, but pathological pain has no obvious biological role. Complementary alternative medicine (CAM) agents are being increasingly studied in the treatment of clinical pain, and some dietary constituents (polyphenol, carotenoids, and fatty acids) and supplements may modify pain pathways. Because these substances modulate neuronal excitability-including the trigeminal pain pathway via various voltage-gated ionic channels and transient receptor potential and ligand-gated channels, dietary constituents could contribute to CAM as therapeutic agents for attenuating orofacial noxious sensory information. This review summarizes the current understanding of the mechanisms by which dietary constituents might attenuate excitability of trigeminal nociceptive neurons implicated in blocking pain, particularly in relation to the authors' recent experimental data, and discusses the development of functional foods and the contribution of dietary constituents in the relief of clinical dental pain without the side effects of nonsteroidal anti-inflammatory drugs.

Language errors in pain medicine: An umbrella review

“…Overall, 48 articles were included (Table 5). Out of the 34 excluded articles, 24 were excluded because they were received or published before the last IASP definition revision (Andriessen et al, 2021;Asseyer et al, 2020;Cao et al, 2020;Carvajal, 2021;Cortes-Altamirano et al, 2020;Crispino & Ciccia, 2021;Della Pietra et al, 2020;Dermer et al, 2020;Ettlin et al, 2021;Kang et al, 2020;Maddern et al, 2020;Marques & Brefel-Courbon, 2021;Miller et al, 2020;Nie et al, 2021;Orhurhu et al, 2020;Reyes-Long et al, 2020;Sagi et al, 2020;Takeda & Shimazu, 2020;Urits et al, 2020;Vincent, 2020;X. Zhang & He, 2020), 7 were excluded because they were not on humans (Chen et al, 2022;Comes et al, 2021;Fakih et al, 2022;Gonçalves et al, 2022;Puja et al, 2021;Shinoda et al, 2022;D.-H. Zhang et al, 2023), 2 because they didn't provide any neurophysiological explanations (Coluzzi et al, 2020;Tueth & Duncan, 2021), and 1 because it wasn't written in English (Pongratz, 2021).…”