Moist exposed burn ointment for treating pressure ulcers

Abstract

Background:Pressure ulcers often seriously affect the quality of life of patients. Moist Exposed Burn Ointment (MEBO) has been developed to treat patients with pressure ulcers. The present study aimed to evaluate the efficacy and safety of MEBO in the treatment of pressure ulcers in Chinese patients.Methods:Seventy-two patients with pressure ulcers were randomly assigned to 2 groups who received a placebo or MEBO for 2 months. The primary outcomes included the wound surface area (WSA) and pressure ulcer scale for healing (PUSH) tool. The secondary outcomes included a visual analog scale (VAS), questionnaire of ulcer status, and adverse effects.Results:Sixty-seven patients completed the study. After 2 months of treatment, the difference of mean change from the baseline was greater for MEBO (vs placebo) for WSA mean (SD) −6.0 (−8.8, −3.3), PUSH Tool −2.6 (−4.7, −1.5), and VAS score −2.9 (−4.4, −1.7). On the basis of the questionnaire, the pressure ulcers were “completely healed” (50.0% vs 16.7%) (P < .05) in patients after 2 months of treatment with MEBO versus placebo. No major adverse effects were found in the 2 groups.Conclusion:We showed that MEBO is effective and well tolerated for improving wound healing in Chinese patients with pressure ulcers.

A topical ointment formulation containing leaves' powder of Lawsonia inermis accelerate excision wound healing in Wistar rats

“…The progressive change in the wound area was monitored on an HD camera on days 0, 3, 6, 9, 12, 15, 18, 21, and 24. Wounds’ pictures have then been uploaded on AutoCAD 2020 (Autodesk, Inc – USA) [ 13 ] to calculate the wound area surface. Wound closure percentage was finally calculated using the following formula:…”

MEBO versus topical Diltiazem versus a combination of both ointments in the treatment of acute anal fissure: a randomized clinical trial protocol

“…Moist exposed burn ointment (MEBO) is a topical Chinese medicine composed of sesame oil and herbal plants [ 26 ] that is clinically used for the treatment of burn wounds [ 27 ]. A study that compared the efficacy of MEBO to a standard therapy in the treatment of partial-thickness facial burns reported comparable rates of wound healing.…”

“…The study also reported that MEBO allowed easier assessment of healing progression, easier application, and was cost-effective [ 28 ]. On the other hand, a randomized controlled clinical trial revealed that MEBO effectively improved pressure ulcer healing compared to placebo [ 26 ]. The possible mechanisms by which MEBO promotes wound healing include increasing neovascularization and fibroblast cells in granulation tissue, and enhancing proliferation of the vascular endothelial cells [ 26 ].…”

“…On the other hand, a randomized controlled clinical trial revealed that MEBO effectively improved pressure ulcer healing compared to placebo [ 26 ]. The possible mechanisms by which MEBO promotes wound healing include increasing neovascularization and fibroblast cells in granulation tissue, and enhancing proliferation of the vascular endothelial cells [ 26 ]. In the Chinese literature, studies that were conducted on MEBO in the treatment of anal fissures found that MEBO is effective in healing anal fissure [ 29 , 30 ].…”

Clinical importance of chemokines and inflammatory cytokines for patient care following percutaneous nephrolithotripsy

“…This clinical investigation (trial no. HMCH2010072508) was performed in strict accordance with the Guide for Hongqi Hospital of Mudanjiang Medical University (20) between May 2010 and October 2015. A total of 348 patients with kidney stones were required to review trial protocols and amendments and provide written informed consent in the Hongqi Hospital of Mudanjiang Medical University.…”