Molecular Analyses of Chorionic-Type Intermediate Trophoblastic Lesions: Atypical Placental Site Nodules are Closer to Placental Site Nodules Than Epithelioid Trophoblastic Tumors

Jeremie, Gaspard; Allias, Fabienne; Trécourt, Alexis; Gaillot-Durand, Lucie; Bolze, Pierre Adrien; Descôtes, Françoise; Tondeur, G; Perrot, Jimmy; Hajri, Touria; You, Benoît; Golfier, François; Lopez, Jonathan; Devouassoux‐Shisheboran, Mojgan

doi:10.1016/j.modpat.2022.100046

Cited by 10 publications

(2 citation statements)

References 20 publications

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“…In conclusion, this patient meets the diagnostic criteria of PSN, but the Ki67 value-added index is between PSN and PSTT/ETT. Combined with morphology, immunohistochemistry, and clinical history, it can be diagnosed as APSN with malignant tendency and more inclined to PSTT [ 10 ]. APSN can be considered a transition state between typical PSN and PSTT/ETT, and the diagnostic criteria are still unclear.…”

Section: Discussionmentioning

confidence: 99%

Atypical Placental Site Nodules within the Diverticulum of the Uterine Incision, a Rare Gestational Trophoblastic Disease Misdiagnosed as Intrauterine Residue: A Case Report

Li,

Shi

et al. 2023

Reprod. Sci.

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Atypical placental site nodule (APSN) is a rare benign gestational trophoblastic disease (GTD). It is a tumor-like transformation that has a certain probability of developing into a placental site trophoblastic tumor (PSTT) or epithelioid trophoblastic tumor (ETT). Because of its atypical clinical presentation, it is difficult to diagnose and susceptible to misdiagnosis highly, thus delaying the patient’s condition. We report a scarce case of atypical nodules at the placental site of the uterine incision diverticulum in a 35-year-old female, who was irregular vaginal bleeding after a cesarean Sect. 2 years. She was diagnosed by several local hospitals with intrauterine residue and was given a variety of Traditional Chinese Medicine (TCM) orally, but the symptoms of irregular vaginal bleeding have not been alleviated. After being transferred to several hospitals, she went to Hubei Maternal and Child Health Hospital for treatment. Under the condition of excluding the second pregnancy, she underwent hysteroscopic resection of lesions and laparoscopic repair of uterine incision diverticulum. The pathological diagnosis after the operation suggested that the focus at the uterine incision was an atypical placental nodule that invaded the myometrium of the uterus. The operation completely removed the focus, and then the patient was followed up every 3 months in the first postoperative year, then every 6 months up to 3 years, and then annually thereafter up to 5 years, and then maybe every 2 years thereafter. The patient’s condition was quickly controlled, and the prognosis was good.

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Section: Discussionmentioning

confidence: 99%

Atypical Placental Site Nodules within the Diverticulum of the Uterine Incision, a Rare Gestational Trophoblastic Disease Misdiagnosed as Intrauterine Residue: A Case Report

Li,

Shi

et al. 2023

Reprod. Sci.

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“…Such therapies will likely arise from an improved understanding of disease biology. While some progress is being made [32][33][34][35][36], it is hampered by a lack of fresh frozen material, cell lines, animal models, and patient-derived xenografts. Thus, for choriocarcinoma, there are only 2 cell lines, which are used to derive xenografts and currently there are no patientderived xenografts.…”

Section: Existing and Future Collaborationsmentioning

confidence: 99%

From National to International Collaboration in Gestational Trophoblastic Disease: Hurdles and Possibilities

Golfier,

Seckl

2023

Gynecol Obstet Invest

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Today most women with gestational trophoblastic disease (GTD) can expect to be cured particularly if they live in middle to high income countries with access to GTD centres. In contrast, countries lacking organized GTD care achieve lower survival rates. This review considers some of the successes and areas for improvement in GTD care that have been achieved through national and international collaborations.

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Atypical epithelioid trophoblastic lesion presenting as pseudocyst from the niche in the cesarean scar: A case report and review of the literature

Taliento,

Loomans,

Dewilde

et al. 2025

European Journal of Obstetrics & Gynecology and Reproductiv

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Molecular Analyses of Chorionic-Type Intermediate Trophoblastic Lesions: Atypical Placental Site Nodules are Closer to Placental Site Nodules Than Epithelioid Trophoblastic Tumors

Cited by 10 publications

References 20 publications

Atypical Placental Site Nodules within the Diverticulum of the Uterine Incision, a Rare Gestational Trophoblastic Disease Misdiagnosed as Intrauterine Residue: A Case Report

Atypical Placental Site Nodules within the Diverticulum of the Uterine Incision, a Rare Gestational Trophoblastic Disease Misdiagnosed as Intrauterine Residue: A Case Report

From National to International Collaboration in Gestational Trophoblastic Disease: Hurdles and Possibilities

Atypical epithelioid trophoblastic lesion presenting as pseudocyst from the niche in the cesarean scar: A case report and review of the literature

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