Molecular analysis in cytological samples obtained by endobronchial or oesophageal ultrasound guided needle aspiration in non-small cell lung cancer

Centeno, Carmen; Mitjà, Pere Serra; Àvila, Marta; Carcereny, Enric; Muñoz-Mármol, Ana M; Morán, Teresa; Castellà, Eva; Sanz-Santos, José; García-Olivé, Ignasi; Ramirez, José Luis; Gratacós, Antoni Rosell; García, F. Andreo

doi:10.1016/j.pulmoe.2020.05.001

Cited by 9 publications

(7 citation statements)

References 24 publications

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“…A molecular analysis was carried out in the vast majority of the patients in whom it was clinically indicated (92.9%). Our data are consistent with previous studies in which a success rate of 78.6-100% was described with EUS-B-FNA of mediastinal lymph nodes and/or pulmonary lesions [15][16][17].…”

Section: Discussionsupporting

confidence: 93%

“…Skovgaard Christiansen et al found that the possibility to biopsy of an intrapulmonary lesion by EUS-B-FNA depends on the distance from the esophagus and the size of the lesion [11]. Tournoy et al and Almeida et al failed to demonstrate a relationship between the accuracy of EBUS-TBNA and the size and the anatomical location of the parenchymal lesion [12][13][14][15][16][17][18][19]. Studies on EBUS-TBNA of mediastinal lymph adenopathies failed to demonstrate a superiority of a specific needle size and technique of aspiration for the diagnostic yield and the molecular analysis [20][21][22][23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

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Accuracy and Predictors of Success of EUS-B-FNA in the Diagnosis of Pulmonary Malignant Lesions: A Prospective Multicenter Italian Study

et al. 2022

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Background: The role of endoscopic ultrasound with bronchoscope fine-needle aspiration (EUS-B-FNA) in the diagnosis of suspected malignant pulmonary lesions adjacent to the esophagus has been poorly investigated. The aim of the present study was to assess the accuracy of EUS-B-FNA for the diagnosis and molecular profiling of paraesophageal pulmonary lesions, as well as its predictors of success. Materials and Methods: Patients who underwent EUS-B-FNA for the diagnosis of paraesophageal lesions were consecutively enrolled in four Italian centers. Demographic, clinical, procedural, pathological, and molecular characteristics of the malignant samples were collected. The primary outcome was the diagnostic accuracy for pulmonary malignancies. Secondary outcomes were diagnostic yield and predictors of success for diagnosis and molecular profiling. Results: 107 adult patients (60 [56.1%] males; median (interquartile range) age: 69 [60–70] years) were enrolled. The diagnostic accuracy of EUS-B-FNA was 95.3% in the overall cohort and 95.2% in the 99 patients with a final diagnosis of malignancy. Neither clinical nor procedural variables significantly affected the diagnostic accuracy, whereas rapid on-site evaluation (ROSE), performed by pathologists or trained pulmonologists, was a strong predictor for a complete molecular profiling (OR [95% CI]: 12.9 [1.2–137.4]; p value: 0.03). Conclusion: EUS-B-FNA is a safe and accurate method for the diagnosis of paraesophageal pulmonary lesions. The presence of ROSE is relevant for a complete molecular profiling in this selected cohort of patients with advanced lung cancer.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Accuracy and Predictors of Success of EUS-B-FNA in the Diagnosis of Pulmonary Malignant Lesions: A Prospective Multicenter Italian Study

et al. 2022

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“…54 Centeno et al reported an adequacy rate of 81.1% for MET amplification testing in cytological specimens. 55…”

Section: Metmentioning

confidence: 99%

“…Cytological material may be suitable for the identification of MET abnormalitiees: a recent report identified a MET mutation by NGS utilizing unstained slides from a cell block of a lung mass 54 . Centeno et al reported an adequacy rate of 81.1% for MET amplification testing in cytological specimens 55 …”

Section: Molecular Markers In Lung Nsclcmentioning

confidence: 99%

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Overview and update on molecular testing in non‐small cell lung carcinoma utilizing endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) samples

Fernández-Aceñero

Arco

Dinarés³

et al. 2022

Diagnostic Cytopathology

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Lung carcinoma remains one of the most frequent and aggressive human neoplasms. Fortunately, in the last decades, the increasing knowledge of the molecular mechanisms leading to cancer development has allowed the use of targeted therapies with improvement of prognosis in many patients. Clinical management has also changed after the introduction of endobronchialultrasonographic bronchoscopy that allows a conservative staging of lung tumors, avoiding the need of mediastinoscopy for lymph node staging. Lung pathologists and cytopathologists are facing the challenge of giving the more comprehensive prognostic and predictive information with ever smaller tissue or cytological samples. The aim of this review is to summarize the molecular testing for non‐small cell lung carcinoma and how pathologists can contribute to the patient's outcome with a conscious management of biological samples.

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Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): revolutionizing the landscape of lung disease diagnostics

Yamamoto,

Nakayama

2023

J Med Ultrasonics

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Molecular analysis in cytological samples obtained by endobronchial or oesophageal ultrasound guided needle aspiration in non-small cell lung cancer

Cited by 9 publications

References 24 publications

Accuracy and Predictors of Success of EUS-B-FNA in the Diagnosis of Pulmonary Malignant Lesions: A Prospective Multicenter Italian Study

Accuracy and Predictors of Success of EUS-B-FNA in the Diagnosis of Pulmonary Malignant Lesions: A Prospective Multicenter Italian Study

Overview and update on molecular testing in non‐small cell lung carcinoma utilizing endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) samples

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): revolutionizing the landscape of lung disease diagnostics

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