Molecular and Cellular Mechanisms of Itch in Psoriasis

Komiya, Eriko; Tominaga, Mitsutoshi; Kamata, Yoichi; Suga, Yasushi; Takamori, Kenji

doi:10.3390/ijms21218406

Cited by 70 publications

(67 citation statements)

References 163 publications

(272 reference statements)

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“…The role of inflammation in psoriatic-related itch origin is undoubtedly relevant, as it is confirmed by elevated concentration of a number of inflammatory mediators and by an antipruritic effect of anti-inflammatory drugs. Various immune cells secrete cytokines that directly or indirectly may aggravate or even induce itch by increasing the inflammatory response [ 45 ]. Nakamura et al analyzed differences in cytokine expression in the epidermis between pruritic and non-pruritic psoriatic patients.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, Madej et al showed that serum concentration of vascular adhesion protein-1 (VAP-1), another adhesion molecule, was significantly higher in the group of psoriatic patients with pruritus vs. those without pruritus [ 50 ]. Prostaglandin E2 (PGE2), endothelin-1 (ET-1) and endothelial leukocyte adhesion protein 1 (ELAM-1) have also been considered to be good candidates as itch mediators in psoriasis but future studies are required to confirm this hypothesis [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

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Molecular Aspects of Pruritus Pathogenesis in Psoriasis

Jaworecka

Muda-Urban

Rzepko

et al. 2021

IJMS

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Psoriasis is a chronic, systemic inflammatory disease with a genetic background that involves almost 3% of the general population worldwide. Approximately, 70–90% of patients with psoriasis suffer from pruritus, an unpleasant sensation that provokes a desire to scratch. Despite the enormous progress in understanding the mechanisms that cause psoriasis, the pathogenesis of psoriasis-related pruritus still remains unclear. In order to improve patients’ quality of life, development of more effective and safer antipruritic therapies is necessary. In turn to make it possible, better understanding of complexed and multifactorial pathogenesis of this symptom is needed. In this article we have systematized the current knowledge about pruritus origin in psoriasis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Molecular Aspects of Pruritus Pathogenesis in Psoriasis

Jaworecka

Muda-Urban

Rzepko

et al. 2021

IJMS

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“…Among the most prevalent symptoms of psoriasis such as scaling, thickening of skin lesion, and redness, itch is not visible [90]. Historically, itch has been used to differentiate AD from psoriasis – the former being characterized pruritic, while the latter has often been considered nonpruritic.…”

Section: Psoriasismentioning

confidence: 99%

“…Psoriasis is the most prevalent, chronic, inflammatory, and multisystem disease with primarily skin and joint manifestations that affects millions of people worldwide with a deleterious impact on their quality of life [89][90][91][92][93]. The term psoriasis, derived from the Greek word "psora," can also be translated as "to itch" [94].…”

Section: Psoriasismentioning

confidence: 99%

Capsaicin: Plants of the Genus Capsicum and Positive Effect of Oriental Spice on Skin Health

Basharat

Gilani

Iftikhar

et al. 2020

Skin Pharmacol Physiol

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Background: Capsaicin, the main pungent ingredient in hot chili peppers, causes excitation of small sensory neurons. It also provides the basic pungent flavor in Capsicum fruits. Summary: Capsaicin plays a vital role as an agonist for the TRPV1 (transient receptor potential cation channel, subfamily V, member 1) receptor. TRPV1 is essential for the reduction of oxidative stress, pain sensations, and inflammation. Therefore, it has many pros related to health issue. Activation and positive impact of TRPV1 via capsaicin has been studied in various dermatological conditions and in other skin-related issues. Past studies documented that capsaicin plays a vital role in the prevention of atopic dermatitis as well as psoriasis. Moreover, TRPV1 is also very important for skin health because it acts as a capsaicin receptor. It is found in nociceptive nerve fibers and nonneural structures. It prompts the release of a compound that is involved in communicating pain between the spinal cord nerves and other parts of the body. Key Messages: Here, we summarize the growing evidence for the beneficial role of capsaicin and TRPV1 and how they help in the relief of skin diseases such as inflammation, permeation, dysfunction, atopic dermatitis, and psoriasis and in pain amplification syndrome.

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“…Approximately 60–90% of patients with psoriasis have pruritus, and it deteriorates their quality of life. Komiya et al reviewed the features of pruritus in psoriasis and discussed the mechanisms by which a variety of itch mediators induce or aggravate itch in psoriasis [ 8 ]. Various types of neuropeptides, substance P, calcitonin gene-related peptide, neuropeptide Y, act on nerves to induce itch.…”

mentioning

confidence: 99%

Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated

Kanda

2021

IJMS

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Psoriasis is a chronic inflammatory skin disease characterized by IL-17-dominant abnormal innate and acquired immunity, and the hyperproliferation and aberrant differentiation of epidermal keratinocytes, and comorbid arthritis or cardiometabolic diseases. This Special Issue presented updated information on pathogenesis, comorbidities, and therapy of psoriasis. The pathogenesis of psoriasis may involve the dysfunction of indoleamine 2,3-dioxygenase 2 or of UBA domain containing 1-mediated regulation of CARD14/CARMA2sh. The blood cells of psoriasis patients showed the enhanced oxidative stress/autophagy flux and decreased 20S proteasome activity. Elafin, clusterin, or selenoprotein P may act as biomarkers for psoriasis and comorbid metabolic diseases. The proteomic profile of psoriasis lesions showed the dysfunction of dermal fibroblasts; up-regulation of proinflammatory factors and signal transduction or down-regulation of structural molecules. The skin inflammation in psoriasis may populate certain gut bacteria, such as Staphylococcus aureus and Streptococcus danieliae, which worsen the skin inflammation in turn. The psoriasis-associated pruritus may be caused by immune, nervous, or vascular mechanisms. In addition to current oral treatments and biologics, a new treatment option for psoriasis is now being developed, such as retinoic-acid-receptor-related orphan nuclear receptor γt inhibitors, IL-36 receptor antagonist, or aryl hydrocarbon receptor agonist. Antimicrobial peptides and innate immune cells, involved in the pathogenesis of psoriasis, may be novel therapeutic targets. The pathomechanisms and responses to drugs in collagen diseases are partially shared with and partially different from those in psoriasis. Certain nutrients can exacerbate or regulate the progress of psoriasis. The articles in this Special Issue will encourage attractive approaches to psoriasis by future researchers.

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Molecular and Cellular Mechanisms of Itch in Psoriasis

Cited by 70 publications

References 163 publications

Molecular Aspects of Pruritus Pathogenesis in Psoriasis

Molecular Aspects of Pruritus Pathogenesis in Psoriasis

Capsaicin: Plants of the Genus <b><i>Capsicum</i></b> and Positive Effect of Oriental Spice on Skin Health

Psoriasis: Pathogenesis, Comorbidities, and Therapy Updated

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