Molecular and functional characterization of a mitochondrial glutathione reductase homolog from redlip mullet (Liza haematocheila): Disclosing its antioxidant properties in the fish immune response mechanism

Harasgama, J.C.; Kasthuriarachchi, T.D.W.; Kwon, Hyukjae; Wan, Qiang

doi:10.1016/j.dci.2020.103785

Cited by 8 publications

(5 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…116 This cytoplasmic copper control is primarily made possible by glutathione (GSH), a tripeptide with potent antioxidant properties, which is bound by copper. 117 In order to avoid large quantities of harmful unbound copper ions and to provide a negative metal gradient for Ctr1-regulated copper transport, GSH functions as a cytosolic copper buffer. 118 GSH is abundant in the cytoplasm in a millimolar range, 119 which much surpasses the quantity of free copper ions.…”

Section: Copper Transport Mechanismsmentioning

confidence: 99%

See 1 more Smart Citation

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

et al. 2023

View full text Add to dashboard Cite

show abstract

Section: Copper Transport Mechanismsmentioning

confidence: 99%

“…116 This cytoplasmic copper control is primarily made possible by glutathione (GSH), a tripeptide with potent antioxidant properties, which is bound by copper. 117…”

Section: Copper Transport Mechanismsmentioning

confidence: 99%

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The combined results of the selected articles from the random-effect model suggested a strong and positive modulation of both SOD (WMD: 5.85; 95% CI: −2.93, 8.77; I 2 = 99%; p = < 0.00001) (Figure 6A) and CAT (WMD: 3.33; 95% CI: 1.59, 5.07; I 2 = 95%; p = < 0.00001) (Figure 6B). Specifically, Hoseinifar and colleagues reported the strongest modulation of SOD after A clear correlation between the fish physiological state and their antioxidant defense system has been extensively described in previously scientific reports [84,85]. In particular, higher enzyme efficiency or a greater amount of non-soluble antioxidants play an effective role in mediating host benefit [85].…”

Section: Agri-food Waste and Antioxidant Defense Systemmentioning

confidence: 90%

Can Agri-Food Waste Be a Sustainable Alternative in Aquaculture? A Bibliometric and Meta-Analytic Study on Growth Performance, Innate Immune System, and Antioxidant Defenses

Bertocci

Mannino

2022

Foods

View full text Add to dashboard Cite

The agri-food industry generates a large amount of waste every year, which is both an environmental and economic problem, especially for the countries in charge of its disposal. Over the years, there has been a growing interest especially in plant waste, since they are rich in compounds with high nutritional and nutraceutical value. As a result, several scientific disciplines are investigating their alternative use in the formulation of dietary supplements for human or animal use, or as biostimulants for agricultural purposes. In this review, using a meta-analytical approach, we summarize the main and most recent findings related to the use of plant waste as potential ingredients in dietary supplementation for fish grown under controlled experimental conditions. In particular, in this review, it has been highlighted that plant waste may have not only positive effects on growth performance, but also beneficial effects on modulation of the innate immune system and antioxidant defenses. Finally, the bibliometric study and a mapping provide an overview of the recent publications, showing the research strength across the country, the number of potential collaborations among institutions, and the main research focus, demonstrating how this topic is growing in interest, especially in Europe.

show abstract

“…Indeed, the highest GR activity was observed six months after vaccination (Table 1). GR is a biologically important enzyme involved in the conversion of oxidized glutathione into GSH, with the catalytic activity of NADPH 2 (Harasgama et al 2020). In the current study, CAT activity was not significantly affected by vaccination against Y. ruckeri, except in the first month.…”

Section: Discussionmentioning

confidence: 99%

Time-dependent changes in oxidative stress biomarkers and activities of lysosomal and antioxidant enzymes in hepatic tissue of rainbow trout (Oncorhynchus mykiss Walbaum) following vaccination against Yersinia ruckeri

Tkaczenko,

Grudniewska,

Pękala-Safińska

et al. 2023

Fisheries &Amp; Aquatic Life

View full text Add to dashboard Cite

This study analyzed time-dependent effects of vaccination against Y. ruckeri on the oxidative mechanism underlying those effects by detecting relevant lipid peroxidation (2-thiobarbituric acid reactive substances, TBARS) and protein oxidation biomarkers [aldehydic and ketonic derivatives of oxidatively modified proteins (OMP)], antioxidant defenses [activities of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), total antioxidant capacity (TAC)], as well as activities of lysosomal functioning [alanyl aminopeptidase (AAP), leucyl aminopeptidase (LAP), acid phosphatase (AcP), and β-N-acetylglucosaminidase (NAG)] in hepatic tissue of rainbow trout, Oncorhynchus mykiss (Walbaum) following anti-Y. ruckeri vaccination in the first, second, and sixth months. A concentrated vaccine with Y. ruckeri strains was enclosed in fish feed and was administered three times every other day. Rainbow trout from each group were euthanized 31, 61, and 181 days following vaccination, and hepatic tissue was sampled for analysis. In the current study, vaccination against Y. ruckeri resulted in a no statistically significant change in TBARS levels, while aldehydic and ketonic derivatives of OMP in hepatic tissue decreased, especially after the first and second months following immunization. Moreover, the activities of glutathione-dependent enzymes increased, especially after the first and sixth months. The highest TAC levels were observed two and six months after vaccination. It has been shown that vaccination-related oxidative stress in hepatic tissue is involved in adaptive responses through the temporary mobilization of antioxidant and lysosomal enzymes in rainbow trout. The present study showed the effect of vaccination on lysosome membrane permeability for carbohydrate cleavage after the development of immunity against Yersinia, whereas antioxidant defence was reduced. Our results confirmed that the concept of preserving antioxidant enzyme function after vaccination was also evident when CAT, GR, and GPx activities either increased or were unchanged following vaccination.

show abstract

Molecular and functional characterization of a mitochondrial glutathione reductase homolog from redlip mullet (Liza haematocheila): Disclosing its antioxidant properties in the fish immune response mechanism

Cited by 8 publications

References 46 publications

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

Addressing the gaps in homeostatic mechanisms of copper and copper dithiocarbamate complexes in cancer therapy: a shift from classical platinum-drug mechanisms

Can Agri-Food Waste Be a Sustainable Alternative in Aquaculture? A Bibliometric and Meta-Analytic Study on Growth Performance, Innate Immune System, and Antioxidant Defenses

Time-dependent changes in oxidative stress biomarkers and activities of lysosomal and antioxidant enzymes in hepatic tissue of rainbow trout (Oncorhynchus mykiss Walbaum) following vaccination against Yersinia ruckeri

Contact Info

Product

Resources

About