Molecular and genetic abnormalities in radial scar

Iqbal, Mussawar; Shoker, Balvinder; Foster, Christopher S.; Jarvis, Christine; Sibson, D. Ross; Davies, Michael

doi:10.1053/hupa.2002.125375

Cited by 26 publications

(14 citation statements)

References 21 publications

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“…Molecular evidence to characterize the behavior and biologic potential of RS has found similar patterns in both RS and invasive carcinoma for mRNA expression of factors involved in formation of vascularized stroma [24]. Iqbal et al detected subtle differences in estrogen receptor and Ki67 expression between RS lesions containing epithelial hyperplasia and areas of epithelial hyperplasia outside of the RS lesion, with the RS containing focal clonal areas and slightly diminished estrogen receptor expression [25]. While these findings may suggest that breast tissue containing RS is somehow permissive of proliferation leading to development of carcinoma, clinical studies, including ours, have failed to demonstrate a link with carcinoma [9,12,[15][16][17]26].…”

Section: Discussionmentioning

confidence: 96%

Breast cancer risk in women with radial scars in benign breast biopsies

Berg

Visscher

Vierkant

et al. 2007

Breast Cancer Res Treat

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Background: The risk for subsequent breast cancer in women diagnosed with radial scar lesions (RS) on benign breast biopsy remains controversial. We studied the relative risk of radial scar lesions in a large cohort of patients with benign breast disease (BBD). Methods: Radial scars were identified in a BBD cohort of 9,262 patients biopsied at Mayo Clinic between 1967 and 1991. Radial scar lesions were classified as proliferative disease without atypia (PDWA) unless atypia was present (classified as atypical hyperplasia [AH]). The observed number of breast cancers developing among those with RS was compared to that expected in the general population using standardized incidence ratios (SIRs, mean follow-up interval 17 years). Results: RS were identified in 439 (4.7%) of the cohort members; 382 (87.0%) contained one RS, 42 (9.6%) contained two, 9 (2.0%) contained three, and 6 (1.4%) contained four or more. The majority of RS (356, 82.4%) were less than 5.0 mm in diameter; 60 (13.9%) were 5.0-9.9 mm, and 16 (3.7%) were 10.0 mm or greater. The relative risk for women with PDWA and RS was 1.88 (95% CI, 1.36-2.53), no different than PDWA without RS [relative risk 1.57 (95% CI, 1.37-1.79) (P = 0.29)]. Women with atypical hyperplasia and RS (n = 60) had a relative risk of 2.81 (95% CI, 1.29-5.35), while those with atypia but without RS had a relative risk of 3.97 (95% CI, 2.99-5.19). Conclusions: RS imparts no increased breast cancer risk above that of PDWA or AH without RS.

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Section: Discussionmentioning

confidence: 96%

Breast cancer risk in women with radial scars in benign breast biopsies

Berg

Visscher

Vierkant

et al. 2007

Breast Cancer Res Treat

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“…A recent study comparing mRNA overexpression of factors involved in the formation of vascular stroma in breast carcinoma, RS, and normal breast tissue showed overexpression of these factors in RS and breast carcinoma, suggesting that a similar disturbance in stromal-epithelial interactions may be present in both lesions. 29 Iqbal et al 30 also provided limited evidence that molecular and genetic changes that occur to a greater degree in breast carcinoma and some premalignant lesions are present in a minority of RS. The fact that subsequent breast carcinomas were just as likely to develop in the contralateral versus ipsilateral breast in both the current study and that of Jacobs et al 1 argues that the stromal changes associated with RS at most represent a marker for a permissive environment rather than a precursor to carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Interdependence of radial scar and proliferative disease with respect to invasive breast carcinoma risk in patients with benign breast biopsies

Sanders

Page

Simpson

et al. 2006

Cancer

105

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“…Jacobs et al found mRNA expression of some factors involved in the formation of vascular stoma was similar in radial scars and invasive breast carcinoma [30]. Iqbal et al found a minority of radial scars had some molecular and genetic changes, which were related to breast cancer and premalignant lesions [31].…”

Section: Discussionmentioning

confidence: 99%

Radial Scars and Subsequent Breast Cancer Risk: A Meta-Analysis

Zhu

Zhong

et al. 2014

PLoS ONE

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BackgroundThe relationship between radial scars and breast cancer is unclear, as the results of different studies are inconsistent. We aim to solve the controversy and assess the breast cancer risk of radial scars.MethodsCase-control or cohort studies about radial scars and breast cancer risk published in PubMed, Web of Science and the Cochrane Library from 2000 to 2013 were searched. Heterogeneity for the eligible data was assessed and a pooled odds ratio (OR) with 95% confidence interval (CI) was calculated.ResultsFive observational studies involving 2521 cases and 20290 controls were included in our study. From pooled analysis, radial scars were found to have a 1.33 fold increased risk of breast cancer, but which was not significant (P = 0.138). Sample size contributed to heterogeneity. In subgroup analysis, the results pooled from studies with sample size >2000 show that presence of radial scars was associated with 1.6 times breast cancer risk compared to absence of radial scars. Radial scars increased the risk of breast cancer among women with proliferative disease without atypia, but no significant association between radial scars and carcinoma was noted among women with atypical hyperplasia.ConclusionsRadial scars tend to be associated with an increased breast cancer risk. Radial scars should be considered among women with proliferative disease without atypia, while atypical hyperplasia is still the primary concern among women with both radial scars and atypical hyperplasia.

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Molecular and genetic abnormalities in radial scar

Cited by 26 publications

References 21 publications

Breast cancer risk in women with radial scars in benign breast biopsies

Breast cancer risk in women with radial scars in benign breast biopsies

Interdependence of radial scar and proliferative disease with respect to invasive breast carcinoma risk in patients with benign breast biopsies

Radial Scars and Subsequent Breast Cancer Risk: A Meta-Analysis

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