Molecular and morphologic study of pancreatic cancer evolution

Abstract

Molecular evolution of intraductal neoplasms CHAPTER 2 Pathology of pancreatic cancer precursor lesions CHAPTER 3 Genomic characterization of malignant progression in neoplastic pancreatic cysts CHAPTER 4 Genetic analyses of isolated high-grade pancreatic intraepithelial neoplasia (HG-PanIN) reveal paucity of alterations in TP53 and SMAD4 CHAPTER 5 IPMNs with co-occurring invasive cancers: neighbours but not always relatives CHAPTER 6 Patients with McCune-Albright syndrome have a broad spectrum of abnormalities in the gastrointestinal tract and pancreas PART 2 Three-dimensional histopathology through tissue clearing CHAPTER 7 A "clearer" view of pancreatic pathology: a review of tissue clearing and advanced microscopy techniques CHAPTER 8 Immunolabeling of cleared human pancreata provides insights into three-dimensional pancreatic anatomy and pathology CHAPTER 9 Three-dimensional visualization of cleared human pancreas cancer reveals that sustained epithelial-to-mesenchymal transition is not required for venous invasion CHAPTER 10 Why is pancreatic cancer so deadly? The pathologist's view PART 3 Pancreatic neuroendocrine neoplasms CHAPTER 11 Genetic analysis of small well-differentiated pancreatic neuroendocrine tumors identifies subgroups with differing risks of liver metastases CHAPTER 12 Whole-exome sequencing of duodenal neuroendocrine tumors in patients with neurofibromatosis type 1 CHAPTER 13 Well-differentiated pancreatic neuroendocrine tumor in a patient with familial atypical multiple mole melanoma syndrome (FAMMM) PART 4 Conclusion CHAPTER 14 Summarizing discussion CHAPTER 15 Nederlandse samenvatting PART 5 Appendix Curriculum Vitae