Molecular and physiological evidences for the role in appetite regulation of apelin and its receptor APJ in Ya-fish (Schizothorax prenanti)

Lin, Fangjun; Wu, Hongwei; Hu, Chen; Xin, Zhiming; Yuan, Dengyue; Wang, Tao; Liu, Ju; Gao, Yundi; Zhang, Xin; Zhou, Chaowei; Wei, Ran; Chen, Defang; Yang, Shiyong; Wang, Yan; Pu, Yundan; Li, Zhiqiong

doi:10.1016/j.mce.2014.08.009

Cited by 40 publications

(33 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Both apelin and apjs mRNAs were found in the central nervous system and various peripheral tissues, which is in accordance with the studies in mammals (Kawamata et al, 2001), Falco et al, 2004), Rana catesbeiana (Moon et al, 2007) and other teleost fish (Hao et al, 2017;Lin et al, 2014;Volkoff & Wyatt, 2009). Both apelin and apjs mRNAs were found in the central nervous system and various peripheral tissues, which is in accordance with the studies in mammals (Kawamata et al, 2001), Falco et al, 2004), Rana catesbeiana (Moon et al, 2007) and other teleost fish (Hao et al, 2017;Lin et al, 2014;Volkoff & Wyatt, 2009).…”

Section: Discussionsupporting

confidence: 90%

“…In the present study, our results showed that short-term fasting induced an increase in the expression of apelin and apj mRNA in the hypothalamus, foregut and hepatopancreas of common carp, which is similar to that obtained in the Ya-fish (Lin et al, 2014) and goldfish studies (Volkoff & Wyatt, 2009). In the present study, our results showed that short-term fasting induced an increase in the expression of apelin and apj mRNA in the hypothalamus, foregut and hepatopancreas of common carp, which is similar to that obtained in the Ya-fish (Lin et al, 2014) and goldfish studies (Volkoff & Wyatt, 2009).…”

Section: F I G U R E 7 Effect Of Periprandial Changes On Apelin (A) supporting

confidence: 90%

“…Apelin, apja and apjb were marked by red triangle. In fish, the head kidney and spleen are involved in the immune response (Lin et al, 2014), and studies (De Falco et al, 2004;Habata et al, 1999) confirmed that apelin regulated immune responses. Thus, the apelin/apj system may have a potential role in the digestive tract.…”

Section: Discussionmentioning

confidence: 94%

“…However, the results were not consistent. The apelin mRNA was significantly increased after fasting and was reduced after refeeding in goldfish (Carassius auratus; Volkoff & Wyatt, 2009) and Ya-fish (Schizothorax prenati; Lin et al, 2014). injection of apelin-13 resulted in a reduction in food intake in rats (Lv, Yang, & Chen, 2013).…”

mentioning

confidence: 99%

See 3 more Smart Citations

Apelin and apj in common carp ( Cyprinus carpio L.): Molecular characterization, tissue expression and responses to periprandial changes and fasting–refeeding

et al. 2020

View full text Add to dashboard Cite

Apelin and its receptor apj have a variety of biological functions and are involved in appetite and energy regulation. However, the comparative studies of apelin/apj system in fish are still absent. In this study, the open reading frames of apelin and apja and apjb were obtained. Apelin and apj mRNAs were widely distributed in all tissues detected, with the highest level in the brain, followed by the spleen, kidney and foregut. The mRNA expression of apelin and apjs increased rapidly at mealtime and significantly decreased after 30 min of feeding. In addition, there were obvious circadian rhythms (higher at nighttime and lower at daytime) in the expression of apelin and apja and apjb. Furthermore, fasting elevated the mRNA levels of apelin and apjs in the hypothalamus, foregut and hepatopancreas. When the 8‐day fasted fish were refed, apelin and apjs mRNA expression significantly decreased. However, there were differences in the response to fasting and refeeding between apja and apjb. The roles of apelin and its receptor apjs in fish are poorly understood. Herein, we employed molecular and physiological studies to characterize their structures, distribution and mRNA expression responses to periprandial changes and fasting–refeeding in Cyprinus carpio L. for the first time.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: F I G U R E 7 Effect Of Periprandial Changes On Apelin (A) supporting

confidence: 90%

Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 99%

See 2 more Smart Citations

Apelin and apj in common carp ( Cyprinus carpio L.): Molecular characterization, tissue expression and responses to periprandial changes and fasting–refeeding

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Fasting induces increases in brain apelin mRNA expression in Ya-fish (Lin et al, 2014a) and red-bellied piranha (Volkoff, 2014a). Moreover, in goldfish, the obesogen factor tributyltin (TBT) stimulates food intake and also increases brain apelin expression (Zhang et al, 2016b).…”

Section: Hormones Involved In Food Intakementioning

confidence: 99%

The Neuroendocrine Regulation of Food Intake in Fish: A Review of Current Knowledge

2016

View full text Add to dashboard Cite

Fish are the most diversified group of vertebrates and, although progress has been made in the past years, only relatively few fish species have been examined to date, with regards to the endocrine regulation of feeding in fish. In fish, as in mammals, feeding behavior is ultimately regulated by central effectors within feeding centers of the brain, which receive and process information from endocrine signals from both brain and peripheral tissues. Although basic endocrine mechanisms regulating feeding appear to be conserved among vertebrates, major physiological differences between fish and mammals and the diversity of fish, in particular in regard to feeding habits, digestive tract anatomy and physiology, suggest the existence of fish- and species-specific regulating mechanisms. This review provides an overview of hormones known to regulate food intake in fish, emphasizing on major hormones and the main fish groups studied to date.

show abstract

Apelinergic System Structure and Function

Shin

Kenward

Rainey

2017

Comprehensive Physiology

View full text Add to dashboard Cite

Apelin and apela (ELABELA/ELA/Toddler) are two peptide ligands for a class A G-protein-coupled receptor named the apelin receptor (AR/APJ/APLNR). Ligand-AR interactions have been implicated in regulation of the adipoinsular axis, cardiovascular system, and central nervous system alongside pathological processes. Each ligand may be processed into a variety of bioactive isoforms endogenously, with apelin ranging from 13 to 55 amino acids and apela from 11 to 32, typically being cleaved C-terminal to dibasic proprotein convertase cleavage sites. The C-terminal region of the respective precursor protein is retained and is responsible for receptor binding and subsequent activation. Interestingly, both apelin and apela exhibit isoform-dependent variability in potency and efficacy under various physiological and pathological conditions, but most studies focus on a single isoform. Biophysical behavior and structural properties of apelin and apela isoforms show strong correlations with functional studies, with key motifs now well determined for apelin. Unlike its ligands, the AR has been relatively difficult to characterize by biophysical techniques, with most characterization to date being focused on effects of mutagenesis. This situation may improve following a recently reported AR crystal structure, but there are still barriers to overcome in terms of comprehensive biophysical study. In this review, we summarize the three components of the apelinergic system in terms of structure-function correlation, with a particular focus on isoform-dependent properties, underlining the potential for regulation of the system through multiple endogenous ligands and isoforms, isoform-dependent pharmacological properties, and biological membrane-mediated receptor interaction. © 2018 American Physiological Society. Compr Physiol 8:407-450, 2018.

show abstract

Molecular and physiological evidences for the role in appetite regulation of apelin and its receptor APJ in Ya-fish (Schizothorax prenanti)

Cited by 40 publications

References 48 publications

Apelin and apj in common carp ( Cyprinus carpio L.): Molecular characterization, tissue expression and responses to periprandial changes and fasting–refeeding

Apelin and apj in common carp ( Cyprinus carpio L.): Molecular characterization, tissue expression and responses to periprandial changes and fasting–refeeding

The Neuroendocrine Regulation of Food Intake in Fish: A Review of Current Knowledge

Apelinergic System Structure and Function

Contact Info

Product

Resources

About